A Study for Patients With Neurogenic Orthostatic Hypotension
Public ClinicalTrials.gov record NCT00046475. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multi-Center, Double-Blind, Randomized, Placebo-Controlled, Crossover Study to Assess the Clinical Benefit of Midodrine Hydrochloride in Patients With Neurogenic Orthostatic Hypotension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
We are seeking male and female patients to voluntarily take part in a clinical research study. Patients must be aged 18 or older and diagnosed with symptomatic orthostatic hypotension (low blood pressure while in the upright position) due to Parkinson's disease, multiple system atrophy, pure autonomic failure or autonomic neuropathies (i.e. neurogenic orthostatic hypotension). Symptoms of low blood pressure include dizziness, lightheadedness, changes in vision and generalized weakness upon standing. The main effect of the drug being studied is to increase blood pressure in the upright position so symptoms will decrease. The purpose of this clinical study is to further assess the clinical benefit of midodrine hydrochloride (ProAmatine®), an approved treatment for orthostatic hypotension. During the course of the study, participants will receive either ProAmatine® or a placebo. Assessments will be made using questionnaires that measure symptom and activity levels. Blood pressure in the lying down and standing positions will be measured at each visit.
Study identification
- NCT ID
- NCT00046475
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 140 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 30, 1997
- Primary completion
- Nov 23, 1999
- Completion
- Nov 23, 1999
- Last update posted
- Jun 10, 2021
1997 – 1999
United States locations
- U.S. sites
- 15
- U.S. states
- 13
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| North Alabama Neuroscience Research | Huntsville | Alabama | 35801 | — |
| Dr. Harry Pepe & Associates, Inc. | Miramar | Florida | 33023 | — |
| Suncoast Neuroscience Associates, Inc. | St. Petersburg | Florida | — | — |
| Economou & Associates, LTD | Chicago | Illinois | 60612 | — |
| Johns Hopkins Hospital | Baltimore | Maryland | — | — |
| Michigan Pain and Neurological Institute | Ann Arbor | Michigan | — | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| NY Presbyterian Hospital | New York | New York | 10032 | — |
| Medical College of Ohio | Toledo | Ohio | 43614 | — |
| COR Clinical Research, LLC | Oklahoma City | Oklahoma | 73103 | — |
| Westmoreland Neurology Associates Inc. | Greensburg | Pennsylvania | 15601 | — |
| Neurological Associates of Delaware Valley | Upland | Pennsylvania | 19013 | — |
| Diabetes & Glandular Disease Research Associates, PA | San Antonio | Texas | — | — |
| Monarch Medical Research | Norfolk | Virginia | 23502 | — |
| West Virginia University | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00046475, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 10, 2021 · Synced Sep 9, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00046475 live on ClinicalTrials.gov.