Zoledronic Acid - Letrozole Adjuvant Synergy Trial (ZFAST) - Cancer Treatment Related Bone Loss in Postmenopausal Women With Estrogen Receptor Positive and/or Progesterone Receptor Positive Breast Cancer Receiving Adjuvant Hormonal Therapy
Public ClinicalTrials.gov record NCT00050011. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label, Randomized, Multicenter Study to Evaluate the Use of Zoledronic Acid in the Prevention of Cancer Treatment-Related Bone Loss in Postmenopausal Women With Estrogen Receptor Positive and/or Progesterone Receptor Positive Breast Cancer Receiving Letrozole as Adjuvant Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This protocol is designed to compare the effect on bone of Zoledronic Acid 4 mg every 6 months when given upfront versus delayed start (based on a post-baseline BMD T- Score below -2.0 SD at either the lumbar spine or total hip, or any clinical fracture unrelated to trauma, or an asymptomatic fracture discovered at the month 36 scheduled visit) in stage I-IIIb postmenopausal women with hormone receptor positive breast cancer who will receive Letrozole 2.5 mg daily as an adjuvant therapy.
Study identification
- NCT ID
- NCT00050011
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 602 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2002 (Type not available)
- Primary completion
- Jan 2009 (Actual)
- Completion
- Jan 2009 (Actual)
- Last update posted
- Mar 21, 2014
2002 – 2009
United States locations
- U.S. sites
- 43
- U.S. states
- 24
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Highlands Oncology Group | Springdale | Arkansas | 72764 | — |
| East Valley Hematology & Oncology | Burbank | California | 91505 | — |
| Louisiana Oncology Associates | Lafayette | California | 70506 | — |
| Wilshire Oncology Medical Group | LaVerne | California | 91750 | — |
| Pacific Shores Medical Group | Long Beach | California | 90813 | — |
| Clinical Trials & Research Associates, Inc. | Montebello | California | 90640 | — |
| Redwood Regional Medical Group | Santa Rosa | California | 95403 | — |
| Cancer and Blood Institute of the Desert | Rancho Mirage | Colorado | 92270 | — |
| Eastern Connecticut Hematology/Oncology Associates | Norwich | Connecticut | 06360 | — |
| FL Community Cancer Center | Brooksville | Florida | 34613 | — |
| Robert R. Carroll, MD, PA | Gainesville | Florida | 32605 | — |
| Oncology Hematology Group of South Florida | Miami | Florida | 33176 | — |
| Pasco Pinellas Cancer Center | New Port Richey | Florida | 34652 | — |
| Ocala Oncology Center | Ocala | Florida | 33479 | — |
| Cancer Research Network, Inc. | Plantation | Florida | 33324 | — |
| Bay Area Oncology | Tampa | Florida | 33607 | — |
| Space Coast Medical | Titusville | Florida | 32796 | — |
| Elmhurst Memorial Hospital | Elhurst | Illinois | 60126 | — |
| Kentuckiana Cancer Institute | Louisville | Kentucky | 40202 | — |
| Frederick Memorial Hospital Regional Cancer Therapy Center | Frederick | Maryland | 21701 | — |
| New England Hematology/Oncology Associates | Wellesley | Massachusetts | 02481 | — |
| Cook Research Department at Spectrum Health | Grand Rapids | Michigan | 49503 | — |
| Metro Minnesota CCOP | Saint Louis Park | Minnesota | 55416 | — |
| Hematology-Oncology Centers of the Northern Rockies, PC | Billings | Montana | 59101 | — |
| Methodist Cancer Center | Omaha | Nebraska | 68114 | — |
| Hematology-Oncology Associates of Northern NJ | Morristown | New Jersey | 07962 | — |
| New Mexico Oncology Hematology, Ltd. | Albuquerque | New Mexico | 87109 | — |
| Hemoncare PC | Brooklyn | New York | 11235 | — |
| Odyssey Research Services | Bismarck | North Dakota | 58501 | — |
| Nashat Y. Gabrail MD Inc. | Canton | Ohio | 44718 | — |
| Oncology Partners Network | Cincinnati | Ohio | 45238 | — |
| Physician Associates, Inc. | Cincinnati | Ohio | 45238 | — |
| Dayton Clinical Oncology Program | Dayton | Ohio | 45420 | — |
| University of Pittsburgh Cancer Institute/Magee Womens Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| Charleston Hematology Oncology | Charleston | South Carolina | 29403 | — |
| The Sarah Cannon Cancer Center | Nashville | Tennessee | 37203 | — |
| St. Joseph Regional Cancer Center | Bryan | Texas | 77802 | — |
| Cancer Specialists of South Texas | Corpus Christi | Texas | 78412 | — |
| Center for Oncology Research & Tx. PA | Dallas | Texas | 75230 | — |
| Northern Virginia Oncology Group | Fairfax | Virginia | 22031 | — |
| Virginia Physicians, Inc.- Oncology | Richmond | Virginia | 23294 | — |
| Swedish Cancer Institute | Seattle | Washington | 98122 | — |
| Rockwood Clinic, PS | Spokane | Washington | 99220 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00050011, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 21, 2014 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00050011 live on ClinicalTrials.gov.