A Phase II Study Comparing Low- and High-Dose Alemtuzumab and High-Dose Rebif® in Patients With Early, Active Relapsing-Remitting Multiple Sclerosis
Public ClinicalTrials.gov record NCT00050778. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II, Randomized, Open-Label, Three-Arm Study Comparing Low- and High-Dose Alemtuzumab and High-Dose Subcutaneous Interferon Beta-1a (Rebif®) in Patients With Early, Active Relapsing-Remitting Multiple Sclerosis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This was a Phase II, randomized, open-label, rater-blinded, three-arm study comparing two different doses of alemtuzumab (Lemtrada™) and one dose of subcutaneous (SC) interferon beta-1a (Rebif®) in participants with early, active relapsing-remitting multiple sclerosis (MS) who had not been previously treated with MS therapies other than steroids. The study was conducted for an initial period of 3 years and a follow-up to 5 years or more.
Study identification
- NCT ID
- NCT00050778
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 334 participants
Conditions and interventions
Conditions
Interventions
- Interferon beta-1a Biological
- Alemtuzumab 12 mg Biological
- Alemtuzumab 24 mg Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years to 50 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2002 (Type not available)
- Primary completion
- Sep 2007 (Actual)
- Completion
- Jan 2010 (Actual)
- Last update posted
- Jan 8, 2015
2002 – 2010
United States locations
- U.S. sites
- 31
- U.S. states
- 19
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Scottsdale Arizona | Scottsdale | Arizona | 85259 | — |
| Clinical Trials, Inc | Little Rock | Arkansas | 72205 | — |
| East Bay Physicians Medical Group | Berkeley | California | 94705 | — |
| Nerve Pro Research | Irvine | California | 92618 | — |
| Neuro-Therapeutics, Inc. | Pasadena | California | 91105 | — |
| Neurological Research Institute of the East Bay | Walnut Creek | California | 938-1343 | — |
| Neurologic Research Institute/Mile High Research Center | Denver | Colorado | 80218 | — |
| Neurological Service of Orlando | Orlando | Florida | 32806 | — |
| Neurological Associates/ Research Dept. | Pompano Beach | Florida | 33060 | — |
| Neurology Clinical Research, Inc. | Sunrise | Florida | 3335-6637 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| Medical Research and Health Education | Columbus | Georgia | 31909 | — |
| Consultants in Neurology, Ltd | Northbrook | Illinois | 60062 | — |
| Fort Wayne Neurological Center | Fort Wayne | Indiana | 46805 | — |
| Associate in Neurology | Lexington | Kentucky | 40503 | — |
| University of Maryland -Maryland Center for MS | Baltimore | Maryland | 21201 | — |
| Wayne State University Department of Neurology | Detroit | Michigan | 48201 | — |
| Michigan Institute for Neurological Disorders | Farmington Hills | Michigan | 48334 | — |
| Michigan Medical P.C. Neurology | Grand Rapids | Michigan | 49525 | — |
| Mayo Clinic Rochester Department of Neurology | Rochester | Minnesota | 55905 | — |
| Nevada Neurological Consultants, Ltd. | Las Vegas | Nevada | 89102 | — |
| University Hospital an Medical Center | Stony Brook | New York | 11794 | — |
| ALL-Trials Clinical Research, LLC | Winston-Salem | North Carolina | 27103 | — |
| Neurological Associates of Tulsa, Inc | Tulsa | Oklahoma | 74137 | — |
| Neurosciencies and Pain Research | Allentown | Pennsylvania | 18103-6296 | — |
| Neurology, PC | Knoxville | Tennessee | 37934 | — |
| Baylor College of Medicine | Houston | Texas | — | — |
| Dallas Neurological Associate | Richardson | Texas | 75080 | — |
| Central Texas Neurology Consultants PA | Round Rock | Texas | 78681 | — |
| Integra Clinical Research, LLC | San Antonio | Texas | 78231 | — |
| Neurology Center of San Antonio | San Antonio | Texas | 78258 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 18 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00050778, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 8, 2015 · Synced Oct 27, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00050778 live on ClinicalTrials.gov.