ClinicalTrials.gov record
Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors
ClinicalTrials.gov ID: NCT00053352
Public ClinicalTrials.gov record NCT00053352. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase III trial is studying surgery followed by combination chemotherapy to see how well it works in treating children with germ cell tumors that are not located in the head. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug, and giving them after surgery, may kill any remaining tumor cells following surgery. It is not yet known whether combination chemotherapy is effective in decreasing the recurrence of childhood germ cell tumors.
Study identification
- NCT ID
- NCT00053352
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 302 participants
Conditions and interventions
Conditions
- Childhood Embryonal Tumor
- Childhood Extracranial Germ Cell Tumor
- Childhood Extragonadal Germ Cell Tumor
- Childhood Malignant Ovarian Germ Cell Tumor
- Childhood Malignant Testicular Germ Cell Tumor
- Childhood Teratoma
- Ovarian Embryonal Carcinoma
- Ovarian Yolk Sac Tumor
- Stage II Malignant Testicular Germ Cell Tumor
- Stage IIA Ovarian Germ Cell Tumor
- Stage IIB Ovarian Germ Cell Tumor
- Stage IIC Ovarian Germ Cell Tumor
- Stage III Malignant Testicular Germ Cell Tumor
- Stage IIIA Ovarian Germ Cell Tumor
- Stage IIIB Ovarian Germ Cell Tumor
- Stage IIIC Ovarian Germ Cell Tumor
- Testicular Choriocarcinoma and Yolk Sac Tumor
- Testicular Embryonal Carcinoma
Interventions
- conventional surgery Procedure
- cisplatin Drug
- etoposide Drug
- bleomycin sulfate Biological
- laboratory biomarker analysis Other
Procedure · Drug · Biological + 1 more
Eligibility (public fields only)
- Age range
- Up to 21 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 3, 2003 (Actual)
- Primary completion
- Oct 1, 2013 (Actual)
- Completion
- Jun 30, 2021 (Actual)
- Last update posted
- Jul 13, 2021
2003 – 2021
United States locations
- U.S. sites
- 112
- U.S. states
- 36
- U.S. cities
- 101
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Phoenix Childrens Hospital | Phoenix | Arizona | 85016 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Southern California Permanente Medical Group | Downey | California | 90242 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| Miller Children's Hospital | Long Beach | California | 90806 | — |
| Children's Hospital Los Angeles | Los Angeles | California | 90027 | — |
| Children's Hospital Central California | Madera | California | 93636-8762 | — |
| Children's Hospital and Research Center at Oakland | Oakland | California | 94609-1809 | — |
| Kaiser Permanente-Oakland | Oakland | California | 94611 | — |
| Childrens Hospital of Orange County | Orange | California | 92868-3874 | — |
| Lucile Packard Children's Hospital Stanford University | Palo Alto | California | 94304 | — |
| Sutter General Hospital | Sacramento | California | 95816 | — |
| Rady Children's Hospital - San Diego | San Diego | California | 92123 | — |
| University of California San Francisco Medical Center-Parnassus | San Francisco | California | 94143 | — |
| Children's Hospital Colorado | Aurora | Colorado | 80045 | — |
| Connecticut Children's Medical Center | Hartford | Connecticut | 06106 | — |
| Yale University | New Haven | Connecticut | 06520-8032 | — |
| Alfred I duPont Hospital for Children | Wilmington | Delaware | 19803 | — |
| Children's National Medical Center | Washington D.C. | District of Columbia | 20010 | — |
| Broward Health Medical Center | Fort Lauderdale | Florida | 33316 | — |
| Lee Memorial Health System | Fort Myers | Florida | 33901 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Memorial Healthcare System - Joe DiMaggio Children's Hospital | Hollywood | Florida | 33021 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Miami Children's Hospital | Miami | Florida | 33155 | — |
| All Children's Hospital | St. Petersburg | Florida | 33701 | — |
| Children's Healthcare of Atlanta - Egleston | Atlanta | Georgia | 30322 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31403 | — |
| University of Hawaii | Honolulu | Hawaii | 96813 | — |
| Saint Luke's Mountain States Tumor Institute | Boise | Idaho | 83712 | — |
| Childrens Memorial Hospital | Chicago | Illinois | 60614 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Advocate Hope Children's Hospital | Oak Lawn | Illinois | 60453 | — |
| Saint Jude Midwest Affiliate | Peoria | Illinois | 61602 | — |
| Southern Illinois University | Springfield | Illinois | 62702 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Kosair Children's Hospital | Louisville | Kentucky | 40202 | — |
| Massachusetts General Hospital Cancer Center | Boston | Massachusetts | 02114 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02115 | — |
| Baystate Medical Center | Springfield | Massachusetts | 01199 | — |
| C S Mott Children's Hospital | Ann Arbor | Michigan | 48109 | — |
| Wayne State University | Detroit | Michigan | 48202 | — |
| Saint John Hospital and Medical Center | Detroit | Michigan | 48236 | — |
| Hurley Medical Center | Flint | Michigan | 48502 | — |
| Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan | 49503 | — |
| Michigan State University - Breslin Cancer Center | Lansing | Michigan | 48910 | — |
| Children's Hospitals and Clinics of Minnesota - Minneapolis | Minneapolis | Minnesota | 55404 | — |
| University of Minnesota Medical Center-Fairview | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| The Childrens Mercy Hospital | Kansas City | Missouri | 64108 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Saint Peter's University Hospital | New Brunswick | New Jersey | 08901 | — |
| UMDNJ - Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08903 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| Albany Medical Center | Albany | New York | 12208 | — |
| Brooklyn Hospital Center | Brooklyn | New York | 11201 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| The Steven and Alexandra Cohen Children's Medical Center of New York | New Hyde Park | New York | 11040 | — |
| New York University Langone Medical Center | New York | New York | 10016 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | — |
| Montefiore Medical Center | The Bronx | New York | 10467-2490 | — |
| New York Medical College | Valhalla | New York | 10595 | — |
| Mission Hospitals Inc | Asheville | North Carolina | 28801 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Sanford Medical Center-Fargo | Fargo | North Dakota | 58122 | — |
| Children's Hospital Medical Center of Akron | Akron | Ohio | 44308 | — |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| Rainbow Babies and Childrens Hospital | Cleveland | Ohio | 44106 | — |
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | — |
| The Children's Medical Center of Dayton | Dayton | Ohio | 45404 | — |
| Mercy Children's Hospital | Toledo | Ohio | 43608 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Legacy Emanuel Hospital and Health Center | Portland | Oregon | 97227 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822-2001 | — |
| Penn State Hershey Children's Hospital | Hershey | Pennsylvania | 17033 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Saint Christopher's Hospital for Children | Philadelphia | Pennsylvania | 19134 | — |
| Children's Hospital of Pittsburgh of UPMC | Pittsburgh | Pennsylvania | 15224 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Palmetto Health Richland | Columbia | South Carolina | 29203 | — |
| T C Thompson Children's Hospital | Chattanooga | Tennessee | 37403 | — |
| East Tennessee Childrens Hospital | Knoxville | Tennessee | 37916 | — |
| St. Jude Children's Research Hospital | Memphis | Tennessee | 38105 | — |
| Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| Texas Tech University Health Science Center-Amarillo | Amarillo | Texas | 79106 | — |
| Dell Children's Medical Center of Central Texas | Austin | Texas | 78723 | — |
| Driscoll Children's Hospital | Corpus Christi | Texas | 78411 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Cook Children's Medical Center | Fort Worth | Texas | 76104 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| Covenant Children's Hospital | Lubbock | Texas | 79410 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229-3900 | — |
| Methodist Children's Hospital of South Texas | San Antonio | Texas | 78229 | — |
| Scott and White Memorial Hospital | Temple | Texas | 76508 | — |
| Primary Children's Medical Center | Salt Lake City | Utah | 84113 | — |
| University of Vermont | Burlington | Vermont | 05401 | — |
| Childrens Hospital-King's Daughters | Norfolk | Virginia | 23507 | — |
| Carilion Clinic Children's Hospital | Roanoke | Virginia | 24014 | — |
| Seattle Children's Hospital | Seattle | Washington | 98105 | — |
| West Virginia University Charleston | Charleston | West Virginia | 25304 | — |
| Saint Vincent Hospital | Green Bay | Wisconsin | 54301 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
| Midwest Children's Cancer Center | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00053352, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 13, 2021 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00053352 live on ClinicalTrials.gov.