ClinicalTrials.gov record
TLK286 (Telcyta) vs. Doxil/Caelyx or Hycamtin in Platinum Refractory or Resistant Ovarian Cancer
ClinicalTrials.gov ID: NCT00057720
Public ClinicalTrials.gov record NCT00057720. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 3 Randomized Study of TLK286 (Telcyta) Versus Doxil/Caelyx or Hycamtin as Third-Line Therapy in Platinum Refractory or Resistant Ovarian Cancer [ASSIST-1 (Assessment of Survival In Solid Tumors-1)]
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to demonstrate superiority in survival in favor of TLK286 as compared to active control therapy with Doxil/Caelyx or Hycamtin in the intent-to-treat (ITT) populations.
Study identification
- NCT ID
- NCT00057720
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 440 participants
Conditions and interventions
Conditions
Interventions
- TLK286 HCl for injection Drug
- topotecan hydrochloride for injection Drug
- doxorubicin HCl liposome injection Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2003 (Type not available)
- Primary completion
- Dec 2006 (Actual)
- Completion
- Dec 2006 (Actual)
- Last update posted
- Jul 25, 2011
2003 – 2006
United States locations
- U.S. sites
- 234
- U.S. states
- 37
- U.S. cities
- 149
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Little Rock Hematology Oncology Associates | Little Rock | Arkansas | 72205 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Southern California Permanente Medical Group | Baldwin Park | California | 91706 | — |
| Providence Saint Joseph Medical Center | Burbank | California | 91505-4866 | — |
| Marilyn Norton, M. D. | Chula Vista | California | 91911 | — |
| Rosalba Rodriguez, M. D. | Chula Vista | California | 91911 | — |
| Bay Area Research Cancer Group | Concord | California | 94520 | — |
| Southwest Cancer Care | Escondido | California | 92025 | — |
| California Oncology of the Central Valley | Fresno | California | 93710 | — |
| Kaiser Permanente Oncology Clinical Trials Program | Hayward | California | 94545 | — |
| Gynecologic Oncology Associates | La Jolla | California | 92037 | — |
| Grossmont Hospital | La Mesa | California | 91942 | — |
| Sharp Rees-Stealy | La Mesa | California | 91942 | — |
| LLU Faculty Medical Offices | Loma Linda | California | 92354 | — |
| LLU Faculty Meidical Offices | Loma Linda | California | 92354 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| David Geffen School of Medicine at UCLA | Los Angeles | California | 90095 | — |
| Women's Cancer Center - Community Hospital Los Gatos | Los Gatos | California | 95032 | — |
| Southwest Cancer Care | Murrieta | California | 92562 | — |
| Gyncologic Oncology Associates | Newport Beach | California | 92663 | — |
| Kaiser Permanente Oncology Clinical Trials Program | Oakland | California | 94611 | — |
| N. County Oncology Medical | Oceanside | California | 92056 | — |
| Southwest Cancer Care | Poway | California | 92064 | — |
| Kaiser Permanente Oncology Clinical Trials Program | Redwood City | California | 94063 | — |
| Kaiser Permanente Oncology Clinical Trials Program | Roseville | California | 95661 | — |
| Kaiser Permanente Oncology Clinical Trials Program | Sacramento | California | 95825 | — |
| Southern California Permanente Medical Group | San Diego | California | 92120 | — |
| Medical Oncology Associates-SD | San Diego | California | 92123 | — |
| Sharp Healthcare Clinical Oncology Research | San Diego | California | 92123 | — |
| Sharp Memorial Hospital | San Diego | California | 92123 | — |
| Sharp Rees-Stealy | San Diego | California | 92123 | — |
| Kaiser Permanente Oncology Clinical Trials Program | San Francisco | California | 94115 | — |
| Kaiser Permanente Oncology Clinical Trials Program | San Rafael | California | 94903 | — |
| Kaiser Permanente Oncology Clinical Trials Program | Santa Clara | California | 95051 | — |
| Kaiser Permanente Oncology Clinical Trials Program | Santa Rosa | California | 95403 | — |
| Kaiser Permanente Oncology Clinical Trails Program | Santa Teresa | California | 95119 | — |
| Kaiser Permanente Oncology Clinical Trials Program | South San Francisco | California | 94080 | — |
| Kaiser Permanente Oncology Clinical Trials Program | Vallejo | California | 94589 | — |
| Kaiser Permanente Oncology Clinial Trials Program | Walnut Creek | California | 94596 | — |
| Whittingham Cancer Center at Norwalk Hospital | Norwalk | Connecticut | 06856 | — |
| Hematology Oncology, P.C. | Stamford | Connecticut | 06902 | — |
| The Center for Hematology-Oncology | Boca Raton | Florida | 33486 | — |
| The Center for Hematology-Oncology | Delray Beach | Florida | 33484 | — |
| Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Sheridan Clinical Research, Inc. | Hollywood | Florida | 33021 | — |
| University of Florida Health Science Center/Jacksonville | Jacksonville | Florida | 32209 | — |
| Florida Hospital | Orlando | Florida | 32803 | — |
| Gynecologic Oncology | Orlando | Florida | 32804 | — |
| Florida Hospital Memorial Division, Cancer Care Center | Ormond Beach | Florida | 32174 | — |
| Florida Hospital Memorial Division | Ormond Beach | Florida | 32174 | — |
| Palm Beach Cancer Institute | Palm Beach Gardens | Florida | 33410 | — |
| Gynecologic Oncology Associates | Pembroke Pines | Florida | 33028 | — |
| Hematology/Oncology Associates of Treasure Coast | Port Saint Lucie | Florida | 34952 | — |
| Women's Cancer Research Foundation, Inc. | South Miami | Florida | 33143 | — |
| Palm Beach Cancer Institute | Wellington | Florida | 33414 | — |
| Palm Beach Cancer Institute | West Palm Beach | Florida | 33401 | — |
| Suburban Hematology Oncology | Duluth | Georgia | 30096 | — |
| Suburban Hematology-Oncology Associates | Lawrenceville | Georgia | 30045 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31404 | — |
| Suburban Hematology Oncology | Snellville | Georgia | 30078 | — |
| Kaiser Permanente - Moanalua Medical Center | Honolulu | Hawaii | 96819 | — |
| Straub Clinic and Hospital | Honolulu | Hawaii | 96826 | — |
| Univ. of Hawaii, Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | — |
| North Shore Oncology Hematology Associates | Barrington | Illinois | 60010 | — |
| MacNeal Cancer Center | Berwyn | Illinois | 60402 | — |
| Swedish Covenant Cancer Center | Chicago | Illinois | 60625 | — |
| Hematology Oncology Associates of Illinois (HOAI) | Chicago | Illinois | 60657 | — |
| Cancer Care Specialists of Central IL | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Cancer Care Specialists of Central IL-Crossroads Cancer Care Center | Effingham | Illinois | 62401 | — |
| Joliet Oncology-Hematology Associates, Ltd. | Flossmoor | Illinois | 60422 | — |
| Joliet Oncology-Hematology Associates, Ltd. | Joliet | Illinois | 60435 | — |
| North Shore Oncology Hematology Associates - Deerpath Medical Associates | Lake Forest | Illinois | 60045 | — |
| North Shore Oncology Hematology Associates | Libertyville | Illinois | 60048 | — |
| North Shore Oncology Hematology Associates | McHenry | Illinois | 60050 | — |
| Joliet Oncology-Hematology Associates, Ltd. | Morris | Illinois | 60450 | — |
| Hematology Oncology Associates of Illinois (HOAI) | Skokie | Illinois | 60076 | — |
| Midwest Cancer Research Group, Inc. | Skokie | Illinois | 60077 | — |
| Elkhart General Hospital | Elkhart | Indiana | 46514 | — |
| Michiana Hematology Oncology | Elkhart | Indiana | 46514 | — |
| Indiana Cancer Pavilion | Indianapolis | Indiana | 46202 | — |
| Indiana University Medical Center | Indianapolis | Indiana | 46202 | — |
| St. Vincent Gynecologic Oncology | Indianapolis | Indiana | 46260 | — |
| St. Vincent Hospital and Health Care Center | Indianapolis | Indiana | 46260 | — |
| St. Vincent Hospital and Helath Care Center | Indianapolis | Indiana | 46260 | — |
| Michiana Hematology Oncology | South Bend | Indiana | 46617 | — |
| St. Joseph's Regional | South Bend | Indiana | 46617 | — |
| Saint Joseph's Regional | South Bend | Indiana | 46634 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| Research Support Personnel, LLC | Wichita | Kansas | 67208 | — |
| Associates in Women's Health | Wichita | Kansas | 67214 | — |
| Oncology/Hematology Care, Inc. | Crestview | Kentucky | 41017 | — |
| Univ. of Louisville, Div. of Gynecologic Oncology | Louisville | Kentucky | 40202 | — |
| Hematology and Oncology Specialists, LLC | Covington | Louisiana | 70433 | — |
| OncRx (Pharmacy) | Metairie | Louisiana | 70002 | — |
| Hematology and Oncology Specialists, LLC | New Orleans | Louisiana | 70115 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| LSU Health Sciences Center | Shreveport | Louisiana | 71103 | — |
| Sinai Cancer Institute | Baltimore | Maryland | 21205 | — |
| Center for Cancer and Blood Disorders | Bethesda | Maryland | 20817 | — |
| St. Elizabeth's Med. Ctr. | Boston | Massachusetts | 02135 | — |
| St. Joseph Mercy Hospital | Ann Arbor | Michigan | 48106 | — |
| Sparrow Regional Cancer Center | Lansing | Michigan | 48909 | — |
| St. Mary's Duluth Clinic | Duluth | Minnesota | 55805 | — |
| Ellis Fischel Cancer Center | Columbia | Missouri | 65203 | — |
| St. Louis University, Dept. of Ob-Gyn and Women's Health | St Louis | Missouri | 63117 | — |
| Gynecology & Oncology Consultants, PC | St Louis | Missouri | 63141 | — |
| Saint John's Mercy Hospital | St Louis | Missouri | 63141 | — |
| Deaconess Billings Clinic | Billings | Montana | 59101 | — |
| Hematology & Oncology Centers Northern Rockies | Billings | Montana | 59101 | — |
| Hematology Oncology Centers of the Northern Rockies | Butte | Montana | 59701 | — |
| Horizon's West Medical Group | Scottsbluff | Nebraska | 69361 | — |
| Nevada Cancer Center | Las Vegas | Nevada | 89109 | — |
| Jersey Shore University Medical Center | Neptune City | New Jersey | 07754 | — |
| The Cancer Institute of New Jersey | New Brunswick | New Jersey | 08901 | — |
| Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08903 | — |
| UNM Cancer Research and Treatment Center | Albuquerque | New Mexico | 87131 | — |
| Benjamin Schwartz, M.D. | Babylon | New York | 11702 | — |
| The Mary Imogene Bassett Hospital | Cooperstown | New York | 13326 | — |
| Med-Onc/Hem | Malone | New York | 12953 | — |
| Hematology-Oncology Associates of Rockland | New City | New York | 10956 | — |
| Long Island Jewish Medical Center | New Hyde Park | New York | 11040 | — |
| North Shore-Long Island Jewish Health System/Medical Center | New Hyde Park | New York | 11040 | — |
| Bellevue Hospital Center | New York | New York | 10016 | — |
| Comprehensive Cancer Center Medical Practice Offices | New York | New York | 10016 | — |
| New York University Medical Center - Tisch Hospital | New York | New York | 10016 | — |
| NYU School of Medicine | New York | New York | 10016 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 11021 | — |
| The Union State Bank Cancer Center at Nyack Hospital | Nyack | New York | 10960 | — |
| Gynecologic-Oncology | Rochester | New York | 14620 | — |
| Good Samaritan Hospital Medical Center | West Islip | New York | 11795 | — |
| South Bay OB/GYN | West Islip | New York | 11795 | — |
| Blumenthal Cancer Center | Charlotte | North Carolina | 28203 | — |
| Presbyterian Gynecologic Oncology | Charlotte | North Carolina | 28204 | — |
| Presbyterian Hospital Center for Cancer Research | Charlotte | North Carolina | 28204 | — |
| Piedmont Hematology Oncology Assoc., PA-Salem Research Group | Winston-Salem | North Carolina | 27103 | — |
| Salem Research Group, Inc. | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest University School of Medicine | Winston-Salem | North Carolina | 27157 | — |
| Mid Dakota Clinic | Bismarck | North Dakota | 58501 | — |
| Odyssey Research Services | Bismarck | North Dakota | 58501 | — |
| Dakota Cancer Institute | Fargo | North Dakota | 58103 | — |
| Odyssey Research Services | Fargo | North Dakota | 58104 | — |
| Oncology/Hematology Care, Inc. | Cincinnati | Ohio | 45013 | — |
| Barrett Cancer Center | Cincinnati | Ohio | 45219-0501 | — |
| Barrett Cancer Center | Cincinnati | Ohio | 45219 | — |
| Oncology/Hematology Care, Inc. | Cincinnati | Ohio | 45219 | — |
| UC Physician's Medical Arts Bldg. | Cincinnati | Ohio | 45219 | — |
| UC Physician's Medical Arts Building | Cincinnati | Ohio | 45219 | — |
| University Hospital | Cincinnati | Ohio | 45219 | — |
| Oncology/Hematology Care, Inc. | Cincinnati | Ohio | 45230 | — |
| Oncology/Hematology Care, Inc. | Cincinnati | Ohio | 45236 | — |
| Oncology/Hematology Care, Inc. | Cincinnati | Ohio | 45242 | — |
| Metro Health Medical Center | Cleveland | Ohio | 44109 | — |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | — |
| Mid-Ohio Oncology Hematology St. Anne's | Columbus | Ohio | 43081 | — |
| Mid Ohio Oncology Hematology | Columbus | Ohio | 43213 | — |
| Mid-Ohio Oncology Hematology | Columbus | Ohio | 43213 | — |
| Gynecologic Oncology | Columbus | Ohio | 43222 | — |
| Mount Carmel Health | Columbus | Ohio | 43222 | — |
| Wright State Univ. School of Medicine | Dayton | Ohio | 45409 | — |
| Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio | 44124 | — |
| OU Medical Center - Everett Tower | Oklahoma City | Oklahoma | 73104 | — |
| OU Physicians' Bldg. | Oklahoma City | Oklahoma | 73104 | — |
| Presbyterian | Oklahoma City | Oklahoma | 73104 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Kaiser Permanente Nw, Oncology Research | Portland | Oregon | 97227 | — |
| Oregon Health & Science University | Portland | Oregon | 97239-3098 | — |
| Oregon Health Science University | Portland | Oregon | 97239 | — |
| Abington Mem. Hospita/Rosenfield Cancer Center | Abington | Pennsylvania | 19001 | — |
| Advanced Imaging | Dunmore | Pennsylvania | 18512 | — |
| Hematology & Oncology Associates of NEPA | Dunmore | Pennsylvania | 18512 | — |
| Magee-Womens Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| Viewmont Medical Services | Scranton | Pennsylvania | 18508 | — |
| Community Medical Center | Scranton | Pennsylvania | 18510 | — |
| Mercy Health Partners | Scranton | Pennsylvania | 18510 | — |
| Moses Taylor Hospital | Scranton | Pennsylvania | 18510 | — |
| Associates in Hematology-Oncology, P.C. | Upland | Pennsylvania | 19013 | — |
| Carolina Center of Gynecologic Oncology, PA | Charleston | South Carolina | 29407 | — |
| South Carolina Oncology Associates, PA | Columbia | South Carolina | 29201 | — |
| Gynecologic Oncology Research and Development | Greenville | South Carolina | 29605 | — |
| Gynecologic Oncology Research and Development | Spartanburg | South Carolina | 29303 | — |
| Sioux Valley Clinic Clinical Research Center | Sioux Falls | South Dakota | 57104 | — |
| Sioux Valley Clinic Oncology | Sioux Falls | South Dakota | 57104 | — |
| Sioux Valley Hospital - North Center Radiology | Sioux Falls | South Dakota | 57104 | — |
| Sioux Calley Clinic OBGYN Ltd. | Sioux Falls | South Dakota | 57105 | — |
| Chattanooga Oncology & Hematology Associates, P.C. | Chattanooga | Tennessee | 37404 | — |
| Memorial Hospital | Chattanooga | Tennessee | 37404 | — |
| The Consultant Group | Franklin | Tennessee | 37067 | — |
| The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Gallatin | Tennessee | 37066 | — |
| The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Hermitage | Tennessee | 37076 | — |
| Saint Mary's Health System, Inc. | Knoxville | Tennessee | 37917 | — |
| Hall and Martin, M.D.'s, P.C. | Knoxville | Tennessee | 37920 | — |
| Fort Sanders Parkwest Medical Center | Knoxville | Tennessee | 37923 | — |
| The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Lebanon | Tennessee | 37087 | — |
| The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Murfreesboro | Tennessee | 37130 | — |
| The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| The Consultant Group | Nashville | Tennessee | 37205 | — |
| The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Nashville | Tennessee | 37205 | — |
| The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Nashville | Tennessee | 37207 | — |
| The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Nashville | Tennessee | 37211 | — |
| The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Smyma | Tennessee | 37167 | — |
| Amarillo Cancer Center | Amarillo | Texas | 79106 | — |
| Arlington Cancer Center | Arlington | Texas | 76012 | — |
| Dallas Oncology Consultants | Dallas | Texas | 75201 | — |
| Texas Cancer Associates | Dallas | Texas | 75231 | — |
| Texas Oncology, PA | Fort Worth | Texas | 76104 | — |
| Southwest Fort Worth Cancer Center | Fort Worth | Texas | 76132 | — |
| Univ. of TX, MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Danville Hematology and Oncology, Inc. | Danville | Virginia | 24541 | — |
| Western Washington Oncology | Aberdeen | Washington | 98520 | — |
| Western Washington Oncology | Centralia | Washington | 98531 | — |
| Covington Multicare - Oncology Clinic | Covington | Washington | 98042 | — |
| Western Washington Oncology | Olympia | Washington | 98502 | — |
| Western Washington Oncology | Olympia | Washington | 98506 | — |
| Western Washington Oncology | Shelton | Washington | 98584 | — |
| Allenmore Hospital - Hematology Oncology Clinic | Tacoma | Washington | 98405 | — |
| MultiCare Health System - Medical Oncology | Tacoma | Washington | 98405 | — |
| Chippewa Falls Cancer Center | Chippewa Falls | Wisconsin | 54729 | — |
| Regional Cancer Center | Eau Claire | Wisconsin | 54701 | — |
| Marshfield Clinic Research Foundation | Marshfield | Wisconsin | 54449 | — |
| Saint Joseph's Hospital | Marshfield | Wisconsin | 54449 | — |
| Wisconsin Rapid Cancer Center | Marshfield | Wisconsin | 54494 | — |
| Merrill Cancer Center | Merrill | Wisconsin | 54452 | — |
| Medical Consultants, Ltd. | Milwaukee | Wisconsin | 53215 | — |
| Marshfield Clinc - Lakeland Center | Minocqua | Wisconsin | 54548 | — |
| Marshfield Clinic - Lakeland Center | Minocqua | Wisconsin | 54548 | — |
| Diagnostic Radiology Associates | Rice Lake | Wisconsin | 54868 | — |
| Lakeview Medical Center | Rice Lake | Wisconsin | 54868 | — |
| Marshfield Clinic - Indianhead Center | Rice Lake | Wisconsin | 54868 | — |
| Saint Michael Hospital | Stevens Point | Wisconsin | 54481 | — |
| Wausau Cancer Center | Wausau | Wisconsin | 54401 | — |
| Hematology Oncology Centers of the Northern Rockies | Cody | Wyoming | 82414 | — |
| Hematology Oncology of the Northern Rockies | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 86 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00057720, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 25, 2011 · Synced Oct 30, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00057720 live on ClinicalTrials.gov.