ClinicalTrials.gov record
Brain Irradiation in Treating Patients With Limited-Stage Small Cell Lung Cancer
ClinicalTrials.gov ID: NCT00057746
Public ClinicalTrials.gov record NCT00057746. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II Randomized Trial Of Two Dose Schedules For Delivering Prophylactic Cranial Irradiation For Patients With Limited Disease Small Cell Lung Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which radiation therapy regimen is more effective in preventing brain metastases in patients with limited-stage small cell lung cancer while taking into account chronic neurotoxicity from radiation therapy. PURPOSE: This randomized phase II trial compares the incidence of chronic neurotoxicity between three different brain irradiation regimens. The corresponding phase III component addressing the prevention of brain metastases was run by EORTC and reported separately (NCT00005062).
Study identification
- NCT ID
- NCT00057746
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 265 participants
Conditions and interventions
Conditions
Interventions
- Prophylactic cranial irradiation, 2.5 Gy fx Radiation
- Prophylactic cranial irradiation, 2.0 Gy fx Radiation
- Prophylactic cranial irradiation, 1.5 Gy fx Radiation
Radiation
Eligibility (public fields only)
- Age range
- Up to 120 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 2003 (Type not available)
- Primary completion
- May 2009 (Actual)
- Completion
- Nov 2013 (Actual)
- Last update posted
- May 25, 2016
2003 – 2013
United States locations
- U.S. sites
- 217
- U.S. states
- 33
- U.S. cities
- 163
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham | Birmingham | Alabama | 35294 | — |
| Arizona Oncology Services Foundation | Phoenix | Arizona | 85013 | — |
| Virginia G. Piper Cancer Center at Scottsdale Healthcare - Osborn | Scottsdale | Arizona | 85251 | — |
| Virginia G. Piper Cancer Center at Scottsdale Healthcare - Shea | Scottsdale | Arizona | 85260 | — |
| Highlands Oncology Group - Springdale | Springdale | Arkansas | 72764 | — |
| Auburn Radiation Oncology | Auburn | California | 95603 | — |
| Radiation Oncology Centers - Cameron Park | Cameron Park | California | 95682 | — |
| Rebecca and John Moores UCSD Cancer Center | La Jolla | California | 92093-0658 | — |
| CCOP - Bay Area Tumor Institute | Oakland | California | 94609 | — |
| Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center | Pomona | California | 91767 | — |
| Radiation Oncology Center - Roseville | Roseville | California | 95661 | — |
| Radiological Associates of Sacramento Medical Group, Incorporated | Sacramento | California | 95815 | — |
| Mercy General Hospital | Sacramento | California | 95819 | — |
| Solano Radiation Oncology Center | Vacaville | California | 95687 | — |
| Memorial Hospital Cancer Center - Colorado Springs | Colorado Springs | Colorado | 80909 | — |
| St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center | Grand Junction | Colorado | 81502 | — |
| Tunnell Cancer Center at Beebe Medical Center | Lewes | Delaware | 19958 | — |
| CCOP - Christiana Care Health Services | Newark | Delaware | 19713 | — |
| University of Florida Shands Cancer Center | Gainesville | Florida | 32610-0232 | — |
| University of Miami Sylvester Comprehensive Cancer Center - Miami | Miami | Florida | 33136 | — |
| Baptist-South Miami Regional Cancer Program | Miami | Florida | 33176 | — |
| Bay Medical | Panama City | Florida | 32401 | — |
| Northeast Georgia Medical Center | Gainesville | Georgia | 30501 | — |
| Northwest Community Hospital | Arlington Heights | Illinois | 60005 | — |
| Rush-Copley Cancer Care Center | Aurora | Illinois | 60507 | — |
| St. Joseph Medical Center | Bloomington | Illinois | 61701 | — |
| Graham Hospital | Canton | Illinois | 61520 | — |
| Memorial Hospital | Carthage | Illinois | 62321 | — |
| St. Anthony's Memorial Hospital | Effingham | Illinois | 62401 | — |
| Eureka Community Hospital | Eureka | Illinois | 61530 | — |
| Galesburg Clinic, PC | Galesburg | Illinois | 61401 | — |
| Galesburg Cottage Hospital | Galesburg | Illinois | 61401 | — |
| InterCommunity Cancer Center of Western Illinois | Galesburg | Illinois | 61401 | — |
| Mason District Hospital | Havana | Illinois | 62644 | — |
| Hopedale Medical Complex | Hopedale | Illinois | 61747 | — |
| Joliet Oncology-Hematology Associates, Limited - West | Joliet | Illinois | 60435 | — |
| Kewanee Hospital | Kewanee | Illinois | 61443 | — |
| La Grange Memorial Hospital | La Grange | Illinois | 60525 | — |
| McDonough District Hospital | Macomb | Illinois | 61455 | — |
| Cardinal Bernardin Cancer Center at Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| BroMenn Regional Medical Center | Normal | Illinois | 61761 | — |
| Community Cancer Center | Normal | Illinois | 61761 | — |
| Community Hospital of Ottawa | Ottawa | Illinois | 61350 | — |
| Cancer Treatment Center at Pekin Hospital | Pekin | Illinois | 61554 | — |
| Proctor Hospital | Peoria | Illinois | 61614 | — |
| CCOP - Illinois Oncology Research Association | Peoria | Illinois | 61615 | — |
| Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria | Illinois | 61615 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| OSF St. Francis Medical Center | Peoria | Illinois | 61637 | — |
| Illinois Valley Community Hospital | Peru | Illinois | 61354 | — |
| Perry Memorial Hospital | Princeton | Illinois | 61356 | — |
| St. Margaret's Hospital | Spring Valley | Illinois | 61362 | — |
| Valley Cancer Center | Spring Valley | Illinois | 61362 | — |
| Carle Cancer Center at Carle Foundation Hospital | Urbana | Illinois | 61801 | — |
| CCOP - Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Saint John's Cancer Center at Saint John's Medical Center | Anderson | Indiana | 46016 | — |
| Parkview Regional Cancer Center at Parkview Health | Fort Wayne | Indiana | 46805 | — |
| Indiana University Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202-5289 | — |
| Veterans Affairs Medical Center - Indianapolis | Indianapolis | Indiana | 46202 | — |
| Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte | Indiana | 46350 | — |
| Saint Anthony Memorial Health Centers | Michigan City | Indiana | 46360 | — |
| Cancer Center at Ball Memorial Hospital | Muncie | Indiana | 47303-3499 | — |
| Memorial Hospital of South Bend | South Bend | Indiana | 46601 | — |
| McFarland Clinic, PC | Ames | Iowa | 50010 | — |
| Holden Comprehensive Cancer Center at University of Iowa | Iowa City | Iowa | 52242-1002 | — |
| Cancer Center of Kansas, PA - Chanute | Chanute | Kansas | 66720 | — |
| Cancer Center of Kansas, PA - Dodge City | Dodge City | Kansas | 67801 | — |
| Cancer Center of Kansas, PA - El Dorado | El Dorado | Kansas | 67042 | — |
| Cancer Center of Kansas, PA - Kingman | Kingman | Kansas | 67068 | — |
| Southwest Medical Center | Liberal | Kansas | 67901 | — |
| Cancer Center of Kansas, PA - Newton | Newton | Kansas | 67114 | — |
| Cancer Center of Kansas, PA - Parsons | Parsons | Kansas | 67357 | — |
| Cancer Center of Kansas, PA - Pratt | Pratt | Kansas | 67124 | — |
| Cancer Center of Kansas, PA - Salina | Salina | Kansas | 67042 | — |
| Cotton-O'Neil Cancer Center | Topeka | Kansas | 66606 | — |
| St. Francis Comprehensive Cancer Center | Topeka | Kansas | 66606 | — |
| Cancer Center of Kansas, PA - Wellington | Wellington | Kansas | 67152 | — |
| Associates in Womens Health, PA - North Review | Wichita | Kansas | 67203 | — |
| Cancer Center of Kansas, PA - Medical Arts Tower | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas, PA - Wichita | Wichita | Kansas | 67214 | — |
| CCOP - Wichita | Wichita | Kansas | 67214 | — |
| Via Christi Cancer Center at Via Christi Regional Medical Center | Wichita | Kansas | 67214 | — |
| Wesley Medical Center | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas, PA - Winfield | Winfield | Kansas | 67156 | — |
| Lucille P. Markey Cancer Center at University of Kentucky | Lexington | Kentucky | 40536-0093 | — |
| Greenebaum Cancer Center at University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Union Hospital Cancer Program at Union Hospital | Elkton MD | Maryland | 21921 | — |
| Boston University Cancer Research Center | Boston | Massachusetts | 02118 | — |
| Hudner Oncology Center at Saint Anne's Hospital - Fall River | Fall River | Massachusetts | 02721 | — |
| South Suburban Oncology Center | Quincy | Massachusetts | 02169 | — |
| Hickman Cancer Center at Bixby Medical Center | Adrian | Michigan | 49221 | — |
| Veterans Affairs Medical Center - Ann Arbor | Ann Arbor | Michigan | 48105 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109-0942 | — |
| Battle Creek Health System Cancer Care Center | Battle Creek | Michigan | 49017 | — |
| Mecosta County Medical Center | Big Rapids | Michigan | 49307 | — |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201-1379 | — |
| Josephine Ford Cancer Center at Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Butterworth Hospital at Spectrum Health | Grand Rapids | Michigan | 49503 | — |
| CCOP - Grand Rapids | Grand Rapids | Michigan | 49503 | — |
| Lacks Cancer Center at Saint Mary's Health Care | Grand Rapids | Michigan | 49503 | — |
| Metro Health Hospital | Grand Rapids | Michigan | 49506 | — |
| Holland Community Hospital | Holland | Michigan | 49423 | — |
| Borgess Medical Center | Kalamazoo | Michigan | 49001 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007-3731 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| Hackley Hospital | Muskegon | Michigan | 49442 | — |
| Lakeland Regional Cancer Care Center - St. Joseph | Saint Joseph | Michigan | 49085 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| Immanuel St. Joseph's | Mankato | Minnesota | 56002 | — |
| CentraCare Clinic - River Campus | Saint Cloud | Minnesota | 56303 | — |
| Regional Cancer Center at Singing River Hospital | Pascagoula | Mississippi | 39581 | — |
| Cancer Institute of Cape Girardeau, LLC | Cape Girardeau | Missouri | 63703 | — |
| CCOP - St. Louis-Cape Girardeau | St Louis | Missouri | 63141 | — |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | — |
| CCOP - Nevada Cancer Research Foundation | Las Vegas | Nevada | 89106 | — |
| Radiation Oncology Associates - Reno | Reno | Nevada | 89509 | — |
| Ocean Medical Center at Meridian Health | Brick | New Jersey | 08724 | — |
| John F. Kennedy Medical Center | Edison | New Jersey | 08818 | — |
| Monmouth Medical Center | Long Branch | New Jersey | 07740-6395 | — |
| Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton | Marlton | New Jersey | 08053 | — |
| Booker Cancer Center at Riverview Medical Center | Red Bank | New Jersey | 07701 | — |
| Frederick R. and Betty M. Smith Cancer Treatment Center | Sparta | New Jersey | 07871 | — |
| J. Phillip Citta Regional Cancer Center at Community Medical Center | Toms River | New Jersey | 08755 | — |
| Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare | Vineland | New Jersey | 08360 | — |
| Cancer Institute of New Jersey at Cooper - Voorhees | Voorhees Township | New Jersey | 08043 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263-0001 | — |
| Tucker Center for Cancer Care at Orange Regional Medical Center | Middletown | New York | 10940-4199 | — |
| Hudson Valley Oncology Associates | Poughkeepsie | New York | 12601 | — |
| Highland Hospital of Rochester | Rochester | New York | 14620 | — |
| James P. Wilmot Cancer Center at University of Rochester Medical Center | Rochester | New York | 14642 | — |
| SUNY Upstate Medical University Hospital | Syracuse | New York | 13210 | — |
| Presbyterian Cancer Center at Presbyterian Hospital | Charlotte | North Carolina | 28233-3549 | — |
| Wayne Memorial Hospital, Incorporated | Goldsboro | North Carolina | 27534 | — |
| Wayne Radiation Oncology | Goldsboro | North Carolina | 27534 | — |
| Leo W. Jenkins Cancer Center at ECU Medical School | Greenville | North Carolina | 27835-6028 | — |
| Kinston Medical Specialists | Kinston | North Carolina | 28501 | — |
| Iredell Memorial Hospital | Statesville | North Carolina | 28677 | — |
| Summa Center for Cancer Care at Akron City Hospital | Akron | Ohio | 44309-2090 | — |
| Aultman Cancer Center at Aultman Hospital | Canton | Ohio | 44710-1799 | — |
| Charles M. Barrett Cancer Center at University Hospital | Cincinnati | Ohio | 45267 | — |
| Huron Hospital Cancer Care Center | Cleveland | Ohio | 44112 | — |
| Euclid Hospital | Cleveland | Ohio | 44119 | — |
| Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | 44195 | — |
| St. Rita's Medical Center | Lima | Ohio | 45801 | — |
| Lima Memorial Hospital | Lima | Ohio | 45804 | — |
| MedCentral - Mansfield Hospital | Mansfield | Ohio | 44903 | — |
| St. Luke's Hospital | Maumee | Ohio | 43537 | — |
| Hillcrest Cancer Center at Hillcrest Hospital | Mayfield Heights | Ohio | 44124 | — |
| St. Charles Mercy Hospital | Oregon | Ohio | 43616 | — |
| Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford | Salem | Ohio | 44460 | — |
| Firelands Regional Medical Center | Sandusky | Ohio | 44870 | — |
| Flower Hospital Cancer Center | Sylvania | Ohio | 43560 | — |
| Mercy Hospital of Tiffin | Tiffin | Ohio | 44883 | — |
| Toledo Hospital | Toledo | Ohio | 43606 | — |
| St. Vincent Mercy Medical Center | Toledo | Ohio | 43608 | — |
| Medical University of Ohio Cancer Center | Toledo | Ohio | 43614 | — |
| CCOP - Toledo Community Hospital | Toledo | Ohio | 43617 | — |
| Toledo Clinic, Incorporated - Main Clinic | Toledo | Ohio | 43623 | — |
| South Pointe Hospital Cancer Care Center | Warrensville Heights | Ohio | 44122 | — |
| Cancer Treatment Center | Wooster | Ohio | 44691 | — |
| Three Rivers Community Hospital | Grants Pass | Oregon | 97527 | — |
| Legacy Mount Hood Medical Center | Gresham | Oregon | 97030 | — |
| Dubs Cancer Center at Rogue Valley Medical Center | Medford | Oregon | 97504 | — |
| Providence Cancer Center at PMCC | Medford | Oregon | 97504 | — |
| Providence Milwaukie Hospital | Milwaukie | Oregon | 97222 | — |
| Legacy Good Samaritan Hospital & Comprehensive Cancer Center | Portland | Oregon | 97210 | — |
| Providence Cancer Center at Providence Portland Medical Center | Portland | Oregon | 97213-2967 | — |
| CCOP - Columbia River Oncology Program | Portland | Oregon | 97225 | — |
| Providence St. Vincent Medical Center | Portland | Oregon | 97225 | — |
| Legacy Emanuel Hospital and Health Center and Children's Hospital | Portland | Oregon | 97227 | — |
| Legacy Meridian Park Hospital | Tualatin | Oregon | 97062 | — |
| Rosenfeld Cancer Center at Abington Memorial Hospital | Abington | Pennsylvania | 19001 | — |
| St. Luke's Cancer Network at St. Luke's Hospital | Bethlehem | Pennsylvania | 18015 | — |
| Dale and Frances Hughes Cancer Center at Pocono Medical Center | East Stroudsburg | Pennsylvania | 18301 | — |
| Penn State Cancer Institute at Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | 19107-5541 | — |
| Fox Chase Cancer Center - Philadelphia | Philadelphia | Pennsylvania | 19111-2497 | — |
| Fox Chase Cancer Center CCOP Research Base | Philadelphia | Pennsylvania | 19140 | — |
| Albert Einstein Cancer Center | Philadelphia | Pennsylvania | 19141 | — |
| McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center | Reading | Pennsylvania | 19612-6052 | — |
| York Cancer Center at Apple Hill Medical Center | York | Pennsylvania | 17405 | — |
| Hollings Cancer Center at Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| CCOP - Greenville | Greenville | South Carolina | 29615 | — |
| Rapid City Regional Hospital | Rapid City | South Dakota | 57701 | — |
| Arlington Cancer Center - Arlington | Arlington | Texas | 76012-2510 | — |
| Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas | Dallas | Texas | 75390 | — |
| M. D. Anderson Cancer Center at University of Texas | Houston | Texas | 77030-4009 | — |
| Cottonwood Hospital Medical Center | Murray | Utah | 84107 | — |
| Jon and Karen Huntsman Cancer Center at Intermountain Medical Center | Murray | Utah | 84157 | — |
| Val and Ann Browning Cancer Center at McKay-Dee Hospital Center | Ogden | Utah | 84403 | — |
| Utah Valley Regional Medical Center - Provo | Provo | Utah | 84604 | — |
| Utah Cancer Specialists at UCS Cancer Center | Salt Lake City | Utah | 84106 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Dixie Regional Medical Center - East Campus | St. George | Utah | 84770 | — |
| St. Joseph Cancer Center | Bellingham | Washington | 98225 | — |
| Harrison Medical Center | Bremerton | Washington | 98310 | — |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98104 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| Group Health Central Hospital | Seattle | Washington | 98112 | — |
| Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | Seattle | Washington | 98122-4307 | — |
| University Cancer Center at University of Washington Medical Center | Seattle | Washington | 98195-6043 | — |
| Cancer Care Northwest - Spokane South | Spokane | Washington | 99202 | — |
| Madigan Army Medical Center - Tacoma | Tacoma | Washington | 98431 | — |
| Southwest Washington Medical Center Cancer Center | Vancouver | Washington | 98668 | — |
| Wenatchee Valley Medical Center | Wenatchee | Washington | 98801-2028 | — |
| Schiffler Cancer Center at Wheeling Hospital | Wheeling | West Virginia | 26003 | — |
| Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | Green Bay | Wisconsin | 54301-3526 | — |
| Green Bay Oncology, Limited at St. Mary's Hospital | Green Bay | Wisconsin | 54303 | — |
| St. Mary's Hospital Medical Center - Green Bay | Green Bay | Wisconsin | 54303 | — |
| St. Vincent Hospital Regional Cancer Center | Green Bay | Wisconsin | 54307-3508 | — |
| Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| Bay Area Cancer Care Center at Bay Area Medical Center | Marinette | Wisconsin | 54143 | — |
| Medical College of Wisconsin Cancer Center | Milwaukee | Wisconsin | 53226 | — |
| Veterans Affairs Medical Center - Milwaukee | Milwaukee | Wisconsin | 53295 | — |
| Regional Cancer Center at Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | 53066 | — |
| All Saints Cancer Center at Wheaton Franciscan Healthcare | Racine | Wisconsin | 53405 | — |
| Waukesha Memorial Hospital Regional Cancer Center | Waukesha | Wisconsin | 53188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00057746, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 25, 2016 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00057746 live on ClinicalTrials.gov.