Oxaliplatin and Bevacizumab (Avastin™) With Either Fluorouracil and Leucovorin or Capecitabine in Treating Patients With Advanced Colorectal Cancer
Public ClinicalTrials.gov record NCT00062426. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Prospective Study Comparing Three Regimens Of Eloxatin ™ Plus Fluoropyrimidine For Evaluation Of Safety And Tolerability In First Line Treatment Of Patients With Advanced Colorectal Cancer (Tree Study)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, fluorouracil, leucovorin, and capecitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving them in different combinations may kill more tumor cells. Monoclonal antibodies, such as bevacizumab (Avastin™), can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or deliver cancer-killing substances to them. It is not yet known which regimen works better in treating advanced colorectal cancer. PURPOSE: This randomized phase III trial is to see if oxaliplatin and bevacizumab work better when combined with either fluorouracil and leucovorin or capecitabine in treating patients who have metastatic or recurrent colorectal cancer.
Study identification
- NCT ID
- NCT00062426
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- Not listed
Conditions and interventions
Conditions
Interventions
- bevacizumab Biological
- capecitabine Drug
- fluorouracil Drug
- leucovorin calcium Drug
- oxaliplatin Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2003 (Type not available)
- Primary completion
- Not listed
- Completion
- Feb 2011 (Actual)
- Last update posted
- Nov 6, 2013
2003 – 2011
United States locations
- U.S. sites
- 52
- U.S. states
- 27
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Comprehensive Cancer Center | Birmingham | Alabama | 35294-3300 | — |
| Arizona Clinical Research Center | Tucson | Arizona | 85712 | — |
| California Cancer Care, Inc. | Greenbrae | California | 94904-2007 | — |
| Valley Tumor Medical Group | Lancaster | California | 93534 | — |
| Cancer and Blood Institute of the Desert | Rancho Mirage | California | 92270 | — |
| Rocky Mountain Cancer Centers - Midtown | Denver | Colorado | 80218 | — |
| Northwestern Connecticut Oncology-Hematology Associates | Torrington | Connecticut | 06790 | — |
| Lombardi Cancer Center at Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| Lynn Regional Cancer Center West | Boca Raton | Florida | 33428 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33901 | — |
| Florida Oncology Associates | Jacksonville | Florida | 32207 | — |
| Hematology and Oncology Consultants, P.A. | Orlando | Florida | 32804 | — |
| Hematology Oncology Associates of theTreasure Coast - Port St. Lucie | Port Saint Lucie | Florida | 34952 | — |
| Palm Beach Cancer Institute | West Palm Beach | Florida | 33401 | — |
| Peachtree Hematology and Oncology Consultants, P.C. | Atlanta | Georgia | 30309 | — |
| North Idaho Cancer Center | Coeur d'Alene | Idaho | 83814 | — |
| Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago | Illinois | 60611 | — |
| Lutheran General Cancer Care Center | Park Ridge | Illinois | 60068-1270 | — |
| West Suburban Center for Cancer Care | River Forest | Illinois | 60305 | — |
| Saint Anthony Medical Center | Rockford | Illinois | 61108 | — |
| CCOP - Northern Indiana CR Consortium | South Bend | Indiana | 46601 | — |
| Cedar Rapids Oncology Associates | Cedar Rapids | Iowa | 52403-1206 | — |
| CCOP - Wichita | Wichita | Kansas | 67214-3882 | — |
| Greater Baltimore Medical Center and Cancer Center | Baltimore | Maryland | 21204 | — |
| Jackson Oncology Associates, PLLC | Jackson | Mississippi | 39202 | — |
| Veterans Affairs Medical Center - Kansas City | Kansas City | Missouri | 64128 | — |
| Deaconess Billings Clinic Cancer Center | Billings | Montana | 59107-5100 | — |
| Cooper Cancer Institute at Cooper University Hospital | Voorhees Township | New Jersey | 08043 | — |
| Advanced Oncology Associates | Armonk | New York | 10504 | — |
| North Shore Hematology/Oncology Associates, P.C. | East Setauket | New York | 11733 | — |
| Arena Oncology Associates | Great Neck | New York | 11021 | — |
| St. Vincents Comprehensive Cancer Center | New York | New York | 10011 | — |
| New York University Medical Center | New York | New York | 10016 | — |
| New York Medical College | Valhalla | New York | 10595 | — |
| Duke Comprehensive Cancer Center | Durham | North Carolina | 27710 | — |
| Southeastern Medical Oncology Center | Goldsboro | North Carolina | 27534 | — |
| Physicians East - Quadrangle | Greenville | North Carolina | 27834 | — |
| Raleigh Hematology/Oncology Associates, P.A. - Wake Practice | Raleigh | North Carolina | 27609-7300 | — |
| Hematology Oncology Consultants Inc | Columbus | Ohio | 43235 | — |
| Hematology/Oncology of Salem | Salem | Oregon | 97301 | — |
| Pennsylvania Oncology Hematology Associates | Philadelphia | Pennsylvania | 19106 | — |
| Hillman Cancer Center at University of Pittsburgh Cancer Institute | Pittsburgh | Pennsylvania | 15232 | — |
| Charleston Hematology-Oncology, P.A. | Charleston | South Carolina | 29403 | — |
| McCleod Cancer and Blood Center | Johnson City | Tennessee | 37604 | — |
| Memphis Cancer Center | Memphis | Tennessee | 38119 | — |
| West Clinic | Memphis | Tennessee | 38120 | — |
| Sarah Cannon Cancer Center at Centennial Medical Center | Nashville | Tennessee | 37203 | — |
| Lone Star Oncology | Austin | Texas | 78759 | — |
| Medical City Dallas Hospital | Dallas | Texas | 75230 | — |
| South Texas Oncology and Hematology | San Antonio | Texas | 78207 | — |
| Center for Cancer Prevention and Care at Scott and White Clinic | Temple | Texas | 76508 | — |
| Medical Consultants | Milwaukee | Wisconsin | 53215-3690 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00062426, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 6, 2013 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00062426 live on ClinicalTrials.gov.