Effects of Low-Dose Doxycycline on Oral Bone Loss

ClinicalTrials.gov ID: NCT00066027

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Official title

Low-Dose Doxycycline Effects on Osteopenic Bone Loss

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The primary purpose of this clinical trial is to determine whether low-dose doxycycline can reduce alveolar bone density loss in postmenopausal osteopenic women with periodontitis and not on hormone replacement therapy (i.e., estrogen deficient).

Study identification

NCT ID: NCT00066027
Recruitment status: Completed
Study type: Interventional
Phase: Phase 3
Lead sponsor: University of Nebraska; Other
Enrollment: 128 participants

Conditions and interventions

Conditions

Periodontitis

Interventions

20 mg doxycycline hyclate Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 45 Years to 70 Years
Sex: Female
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 1, 2002 (Actual)
Primary completion: Oct 1, 2005 (Actual)
Completion: Oct 1, 2005 (Actual)
Last update posted: Sep 6, 2023

2002 – 2005

United States locations

U.S. sites: 2
U.S. states: 2
U.S. cities: 2

Facility	City	State	ZIP	Site status
University of Nebraska Medical Center, College of Dentistry	Lincoln	Nebraska	68583-0740	—
Department of Oral Biology and Pathology	Stony Brook	New York	11794-8702	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT00066027, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 6, 2023 · Synced Nov 12, 2026