ClinicalTrials.gov record
EVEREST: Efficacy of Vasopressin Antagonism in hEart failuRE: Outcome Study With Tolvaptan
ClinicalTrials.gov ID: NCT00071331
Public ClinicalTrials.gov record NCT00071331. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Protocol 156-03-236: Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Long Term Efficacy and Safety of Oral Tolvaptan Tablets in Subjects Hospitalized With Worsening Congestive Heart Failure
Study identification
- NCT ID
- NCT00071331
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
- Industry
- Enrollment
- 3,600 participants
Conditions and interventions
Conditions
Interventions
- Tolvaptan Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 31, 2003
- Primary completion
- Jun 30, 2006
- Completion
- Jun 30, 2006
- Last update posted
- May 2, 2012
2003 – 2006
United States locations
- U.S. sites
- 161
- U.S. states
- 41
- U.S. cities
- 134
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| The Heart Center | Huntsville | Alabama | 35801 | — |
| The Heart Group | Mobile | Alabama | 36608 | — |
| Phoenix Memorial Hospital | Gilbert | Arizona | 85233 | — |
| Arizona Heart Institute | Phoenix | Arizona | 85006 | — |
| Saguaro Clinical Research | Tucson | Arizona | 85712 | — |
| Central Arkansas Veterans Healthcare Systems | Little Rock | Arkansas | 72205 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Bakersfield Memorial Hospital | Bakersfield | California | 93301 | — |
| Central Cardiology Medical Center | Bakersfield | California | 93301 | — |
| Cardiology Associates | Larkspur | California | 94939 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| LAC/USC Medical Center | Los Angeles | California | 90033 | — |
| VA Medical Center- W. Los Angeles | Los Angeles | California | 90073 | — |
| Mission Internal Medical Group | Mission Viejo | California | 92691 | — |
| ARI Clinical Trials | Redondo Beach | California | 92077 | — |
| San Diego Cardiac Center | San Diego | California | 92123 | — |
| Pacific Heart Institute | Santa Monica | California | 90404 | — |
| Cardiovascular Consultants Medical Group, Inc. | Walnut Creek | California | 94598 | — |
| Aurora Denver Cardiology Associates | Denver | Colorado | 80218 | — |
| University of Colorado | Denver | Colorado | 80262 | — |
| Heart and Vascular Clinic of North Colorado | Fort Collins | Colorado | 80528 | — |
| Bakus Resesarch | Norwich | Connecticut | 06360 | — |
| Christiana Care Health System | Newark | Delaware | 19718 | — |
| VA Medical Center | Washington D.C. | District of Columbia | 20422 | — |
| Florida Cardiovascular Research | Atlantis | Florida | 33462 | — |
| Cardiology Associates of Fort Lauderdale | Fort Lauderdale | Florida | 33308 | — |
| Jacksonville Heart Center | Jacksonville | Florida | 32207 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Jacksonville Heart Center | Jacksonville Beach | Florida | 32250 | — |
| Melbourne Internal Medicine Assoc. | Melbourne | Florida | 32901 | — |
| University of Miami/ Jackson Memorial Hospital | Miami | Florida | 33136 | — |
| Miami Research and Education Foundation | Miami | Florida | 33156 | — |
| Ocala Resarch Institute | Ocala | Florida | 34480 | — |
| Cardiology Research Associates | Ormond Beach | Florida | 32174 | — |
| Charlotte Heart Group Research Center | Port Charlotte | Florida | 33952 | — |
| Cardiovascular Center of Sarasota | Sarasota | Florida | 34239 | — |
| The Heart and Vascular Institute of Florida | St. Petersburg | Florida | 33701 | — |
| Cardiac Disease Specialists PC | Atlanta | Georgia | 30309 | — |
| Atlanta Heart and Vascular Research Group | Atlanta | Georgia | 30342 | — |
| Georgia Heart Specialists | Covington | Georgia | 30014 | — |
| Idaho Cardiology Associates | Boise | Idaho | 83704 | — |
| Idaho Cardiology Associates | Meridian | Idaho | 83642 | — |
| North Shore Cardiologists | Bannockburn | Illinois | 60015 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Midwest Heart Research Found. | Lombard | Illinois | 60148 | — |
| Illinois Heart & Lung Associates | Normal | Illinois | 61761 | — |
| Heart Care Midwest | Peoria | Illinois | 61603 | — |
| The Care Group | Indianapolis | Indiana | 46260 | — |
| Mid America Cardiology | Kansas City | Kansas | 66160 | — |
| Cardiovascular Associates | Louisville | Kentucky | 40205 | — |
| Louisville Cardiology Medical Group | Louisville | Kentucky | 40207 | — |
| The Louisiana Heart Center | Chalmette | Louisiana | 70043 | — |
| Northshore Medical Research | Covington | Louisiana | 70433 | — |
| Leonard J Chabert Medical Center | Houma | Louisiana | 70360 | — |
| Lousiana State University Health Sciences Center | Shreveport | Louisiana | 71103 | — |
| Cardiac Centers of LA, LLC | Shreveport | Louisiana | 71135 | — |
| Androscoggin Cardiology Associates | Auburn | Maine | 04210 | — |
| Northeast Cardiology Associates | Bangor | Maine | 04401 | — |
| Maine Medical Center | Portland | Maine | 04102 | — |
| MidAtlantic Cardiovascular Associates | Baltimore | Maryland | 21218 | — |
| Midatlantic Cardiovascular Associates | Baltimore | Maryland | 21229 | — |
| MidAtlantic Cardiovascular Associates | Baltimore | Maryland | 21237 | — |
| Midatlantic Cardiovascular Associates | Bel Air | Maryland | 21014 | — |
| Shore Health System | Easton | Maryland | 21601 | — |
| MidAtlantic Cardiovascular Associates | Towson | Maryland | 21204 | — |
| Heart Associates, P.A. | Towson | Maryland | 21286 | — |
| MidAtlantic Cardiovascular Associates | Westminster | Maryland | 21157 | — |
| Primary Care Cardiology Research | Ayer | Massachusetts | 01432 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Medical Center | Boston | Massachusetts | 02215 | — |
| John Dingell VA Medical Center | Detroit | Michigan | 48201 | — |
| Nisus Research | Petoskey | Michigan | 49770 | — |
| William Beaumont Hospital | Royal Oak | Michigan | 48073-1026 | — |
| Covenant Medical Center | Saginaw | Michigan | 48602 | — |
| Beaumont Hospital | Troy | Michigan | 48085 | — |
| Michigan Heart | Ypsilanti | Michigan | 48197 | — |
| Minneapolis Heart Institute | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55416 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic, Division of Cardiology | Rochester | Minnesota | 55905 | — |
| Park Nicollet Heart Center | Saint Louis Park | Minnesota | 55426 | — |
| Regions Hospital Cardiology Research | Saint Paul | Minnesota | 55101 | — |
| St. Paul Heart Clinic | Saint Paul | Minnesota | 55102 | — |
| Cardiology Associates of North Mississippi | Tupelo | Mississippi | 38801 | — |
| Missouri Cardiovascular Specialists | Columbia | Missouri | 65201 | — |
| VA Medical Center- Kansas City | Kansas City | Missouri | 64128 | — |
| St. Louis University | St Louis | Missouri | 63110 | — |
| Bryan LGH Heart Institute | Lincoln | Nebraska | 68516 | — |
| Heart Consultants | Omaha | Nebraska | 68122 | — |
| New England Heart Institute | Manchester | New Hampshire | 03102 | — |
| Morristown Memorial Hospital | Morristown | New Jersey | 07962-1956 | — |
| University of Medicine and Dentistry of New Jersey | Newark | New Jersey | 07103 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| Garden State Cardiology | Paramus | New Jersey | 07652 | — |
| Albany Associates in Cardiology | Albany | New York | 12212 | — |
| Cardiology Associates, P.C. | Johnson City | New York | 13790 | — |
| North Shore University Hospital | Manhasset | New York | 11030 | — |
| St. Vincents Hospital and Medical Center | New York | New York | 10011 | — |
| St. Lukes-Roosevelt Hospital Centers | New York | New York | 10019 | — |
| New York Presbyterian Hospital | New York | New York | 10032 | — |
| St. Francis Hospital | Roslyn | New York | 11576 | — |
| SUNY | Syracuse | New York | 13230 | — |
| South Bay Cardiovascular Associates | West Islip | New York | 11795 | — |
| Buffalo Cardiology and Pulmonary Associates | Williamsville | New York | 14221 | — |
| Asheville Cardiology Associates | Asheville | North Carolina | 28803 | — |
| Alamance Regional Medical Center | Burlington | North Carolina | 27215 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27514 | — |
| Mid Carolina Cardiology | Charlotte | North Carolina | 28204 | — |
| Durham VA Medical Center | Durham | North Carolina | 27705 | — |
| Duke Cardiology Research | Durham | North Carolina | 27710 | — |
| Pitt County Memorial Hospital, The Heart Center | Greenville | North Carolina | 28735 | — |
| Hendersonville Cardiology | Hendersonville | North Carolina | 28739 | — |
| Akron General Medical Center | Akron | Ohio | 44307 | — |
| Clinical Research Limited | Canton | Ohio | 44718 | — |
| Sterling Research Group | Cincinnati | Ohio | 45219 | — |
| The Lindner Clinical Trial Center | Cincinnati | Ohio | 45219 | — |
| Midwest Cardiology Research Foundation | Columbus | Ohio | 43214 | — |
| The Dayton Heart Center | Dayton | Ohio | 45414 | — |
| Cleveland Cardiovascular Research | Fairview Park | Ohio | 44126 | — |
| North Ohio Research Limited | Lorain | Ohio | 44052 | — |
| North Ohio Research Limited | Sandusky | Ohio | 44870 | — |
| Northwest Ohio Cardiology Consultants | Toledo | Ohio | 43615 | — |
| Integris Heart Research Center | Oklahoma City | Oklahoma | 73112 | — |
| Oklahoma Cardiovascular Research Group | Oklahoma City | Oklahoma | 73120 | — |
| Oregon Health and Science University | Portland | Oregon | 97230 | — |
| Cardiology Consultants of Philadelphia | Philadelphia | Pennsylvania | 19146 | — |
| The Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | 15224 | — |
| Guthrie Clinic, LTD | Sayre | Pennsylvania | 18840 | — |
| Buxmont Cardiology Associates, PC | Sellersville | Pennsylvania | 18960 | — |
| Cardiology Associates of West Reading | West Reading | Pennsylvania | 19611 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02905 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29401 | — |
| Ralph H. Johnson VAMC | Charleston | South Carolina | 29401 | — |
| South Carolina Heart Center | Columbia | South Carolina | 29204 | — |
| The Chattanooga Heart Institute | Chattanooga | Tennessee | 37404 | — |
| Cardiovascular Associates | Kingsport | Tennessee | 37660 | — |
| Baptist Clinical Research Center | Memphis | Tennessee | 38120 | — |
| Stern Cardiovascular Center | Memphis | Tennessee | 38120 | — |
| Vanderbilt Clinical Trials Center | Nashville | Tennessee | 37212 | — |
| The Cardiology Group | Tullahoma | Tennessee | 37388 | — |
| Austin Cardiovascular Associates | Austin | Texas | 78705 | — |
| Southeast Texas Cardiology Associates | Beaumont | Texas | 77702 | — |
| Cardiopulmonary Research Science and Technology Institute | Dallas | Texas | 75230 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555-0553 | — |
| Cardiology Associates Covenant Medical Group | Lubbock | Texas | 79410 | — |
| McAllen Heart Clinic | McAllen | Texas | 78503 | — |
| University of Texas Health Science Center | San Antonio | Texas | 78229-3900 | — |
| Wilford Hall Medical Center, | San Antonio | Texas | 78236 | — |
| Scott & White Clinic Division of Cardiology | Temple | Texas | 76508 | — |
| VA Salt Lake City Health Care System | Salt Lake City | Utah | 84148 | — |
| University of Virginia Medical Center | Charlottesville | Virginia | 22908 | — |
| The Cardiovascular Group PC | Fairfax | Virginia | 22031 | — |
| Inova Institute of Research | Falls Church | Virginia | 22042 | — |
| Medical College of Virginia | Richmond | Virginia | 23219 | — |
| Cardiovascular Associates of Virginia | Richmond | Virginia | 23225 | — |
| Roanoke Heart Institute | Roanoke | Virginia | 24014 | — |
| Empire Health Services | Spokane | Washington | 99204 | — |
| Rockwood Clinic | Spokane | Washington | 99204 | — |
| CAMC Clinical Trials | Charleston | West Virginia | 25304 | — |
| Wisconsin Center For Clinical Research | Elkhorn | Wisconsin | 53121 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 217 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00071331, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 2, 2012 · Synced Apr 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00071331 live on ClinicalTrials.gov.