Valproate in Dementia (VALID)
Public ClinicalTrials.gov record NCT00071721. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Trial of Valproate to Attenuate the Progression of Alzheimer's Disease (AD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this trial is to demonstrate whether valproate therapy delays the emergence of agitation and/or psychosis in outpatients with probable Alzheimer's disease (AD) who have not experienced agitation and psychosis in their illness. A secondary aim is to determine whether valproate therapy delays the progression of cognitive and functional measures of the illness. This trial will also assess the tolerability and safety of low-dose, long-term valproate therapy. Valproate, an anticonvulsant drug, was selected because of its possible symptomatic efficacy for agitation in AD, known safety profile in numerous clinical populations, and in view of recent data supporting its neuroprotective potential in AD.
Study identification
- NCT ID
- NCT00071721
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 313 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 55 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 2003 (Type not available)
- Primary completion
- Feb 2009 (Actual)
- Completion
- Dec 2009 (Actual)
- Last update posted
- Sep 25, 2014
2003 – 2009
United States locations
- U.S. sites
- 46
- U.S. states
- 22
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Sun Health Research Institute | Sun City | Arizona | 85351 | — |
| University of Arizona | Tucson | Arizona | 85724 | — |
| University of California, Irvine | Irvine | California | 92697-4540 | — |
| University of California, ADRC, San Diego | La Jolla | California | 92093-0624 | — |
| VA Healthcare System Long Beach | Long Beach | California | 90822 | — |
| University of Southern California | Los Angeles | California | 90089-0191 | — |
| University of California ADRC | Los Angeles | California | 90095-1769 | — |
| University of California, LA (Olive View) | Los Angeles | California | 90095 | — |
| Pacific Research Network | San Diego | California | 32103 | — |
| Stanford University, VA Aging Clinical Research Center | Stanford | California | 94304 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06511 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20057 | — |
| Howard University | Washington D.C. | District of Columbia | 20060 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| Wein Center, Mount Sinai Medical Center | Miami | Florida | 33140 | — |
| University of South Florida | Tampa | Florida | 33617 | — |
| Byrd Institute | Tampa | Florida | 33647 | — |
| Premier Research Institute | West Palm Beach | Florida | 33407 | — |
| Emory University | Atlanta | Georgia | 30329 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Southern Illinois University | Springfield | Illinois | 62794 | — |
| Indiana University School of Medicine | Indianapolis | Indiana | 46202-5120 | — |
| University of Kansas | Kansas City | Kansas | 66160 | — |
| Lahey Clinic, Research Neurology | Burlington | Massachusetts | 01805 | — |
| University of Michigan | Ann Arbor | Michigan | 48109-0489 | — |
| Saint Mary's Health Care | Grand Rapids | Michigan | 49503 | — |
| St. Louis University | St Louis | Missouri | 63103 | — |
| University of Nevada | Las Vegas | Nevada | 89154-5084 | — |
| Albany Medical Center | Albany | New York | 12208 | — |
| Dent Neurologic Institute | Amherst | New York | 14226 | — |
| New York University Medical Center | New York | New York | 10016 | — |
| Columbia University | New York | New York | 10032 | — |
| Global Research and Consulting | Olean | New York | 14760 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Syracuse VA Medical Center | Syracuse | New York | 13210 | — |
| North East Ohio Health Services | Beachwood | Ohio | 44122 | — |
| Case Western Reserve University, University Hospitals of Cleveland | Cleveland | Ohio | 44120 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104-4283 | — |
| Brown University, Memorial Hospital of Rhode Island | Providence | Rhode Island | 02860 | — |
| Medical University of South Carolina-Columbia | Columbia | South Carolina | 29203 | — |
| Medical University of South Carolina-Florence | Florence | South Carolina | 29502 | — |
| Medical University of South Carolina | North Charleston | South Carolina | 29406-6076 | — |
| Psychiatric Consultants | Nashville | Tennessee | 37203 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390-9070 | — |
| Southwestern Vermont Medical Center | Bennington | Vermont | 05201 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00071721, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 25, 2014 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00071721 live on ClinicalTrials.gov.