A Humanized Anti-Interferon-γ Monoclonal Antibody (HuZAF) for Moderate to Severe Crohn's Disease
Public ClinicalTrials.gov record NCT00072943. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II, Double-Blind, Placebo-Controlled Study to Determine the Safety and Efficacy of a Humanized Anti-Interferon-γ Monoclonal Antibody (HuZAF) Administered to Patients With Moderate to Severe Crohn's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the HARMONY study is to assess the safety and efficacy of an investigational drug called HuZAF, in patients with moderate to severe Crohn's disease (CD). HuZAF is a humanized anti-Interferon-gamma (anti-IFN-γ) monoclonal antibody, which binds and blocks IFN-γ, a protein in the immune system that is involved in inflammation. Antibodies are proteins normally produced by our immune system to help fight off foreign substances. Scientists have been able to make therapeutic humanized monoclonal antibodies, similar to the antibodies in our bodies, to target diseases.
Study identification
- NCT ID
- NCT00072943
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 175 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2002 (Type not available)
- Primary completion
- Apr 2004 (Actual)
- Completion
- Apr 2004 (Actual)
- Last update posted
- Mar 13, 2012
2002 – 2004
United States locations
- U.S. sites
- 15
- U.S. states
- 12
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Advanced Clinical Research Institute | Anaheim | California | 92801 | — |
| Doctor's Office | Orange | California | 92868 | — |
| Gainesville VA Medical Center | Gainesville | Florida | 32608 | — |
| Waterside Clinical Research Services, Inc. | West Palm Beach | Florida | 33407 | — |
| Atlanta Gastroenterology Associates | Atlanta | Georgia | 30342 | — |
| Doctor's Office | Chicago | Illinois | 60637-1426 | — |
| University of Kentucky Medical Center, Division of Digestive Disease & Nutrition | Lexington | Kentucky | 40536 | — |
| Massachusetts General Hospital, Gastrointestinal Unit | Boston | Massachusetts | 02114 | — |
| Gastroenterology Specialities P.C. | Lincoln | Nebraska | 68503 | — |
| Carolina Digestion Health Associates | Charlottesville | North Carolina | 28211 | — |
| Consultants for Clinical Research | Cincinnati | Ohio | 45219 | — |
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| University Pittsburgh Medical Center, Division of Gastroenterology, Hepatology and Nutrition, Inflammatory Bowel Disease Center | Pittsburgh | Pennsylvania | 15261 | — |
| Houston Medical Research Associates | Houston | Texas | 77090 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00072943, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 13, 2012 · Synced Oct 29, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00072943 live on ClinicalTrials.gov.