Prospective Evaluation of Anti-retroviral Combinations for Treatment Naive, HIV Infected Persons in Resource-limited Settings
Public ClinicalTrials.gov record NCT00084136. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized, Open-Label Evaluation of Efficacy of Once-Daily Protease Inhibitor and Once-Daily Non-Nucleoside Reverse Transcriptase Inhibitor-Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Persons From Resource-Limited Settings (PEARLS) Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study compared 3 different three-drug combinations in HIV infected individuals starting their first HIV treatment regimens. Participants were recruited from resource-limited areas in Africa, Asia, South America, Haiti, and also from the United States. The study hypothesis was each of the once daily combinations (PI based, or NNRTI based) would not have inferior efficacy compared to the twice daily NNRTI based combination.
Study identification
- NCT ID
- NCT00084136
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 1,571 participants
Conditions and interventions
Conditions
Interventions
- Atazanavir Drug
- Didanosine (enteric-coated) Drug
- Efavirenz Drug
- Emtricitabine Drug
- Emtricitabine/Tenofovir disoproxil fumarate Drug
- Lamivudine/Zidovudine Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2005 (Type not available)
- Primary completion
- May 2010 (Actual)
- Completion
- May 2010 (Actual)
- Last update posted
- Oct 10, 2018
2005 – 2010
United States locations
- U.S. sites
- 27
- U.S. states
- 13
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Southern California | Los Angeles | California | 90033-1079 | — |
| UCLA CARE Center CRS | Los Angeles | California | 90095-1793 | — |
| Harbor General/UCLA | Torrance | California | 90502-2052 | — |
| Univ. of Colorado Health Sciences Center, Denver | Denver | Colorado | — | — |
| Univ. of Hawaii at Manoa, Leahi Hosp. | Honolulu | Hawaii | 96816-2396 | — |
| Northwestern University | Chicago | Illinois | 60611-3015 | — |
| Rush-Presbyterian/St. Lukes (Chicago) | Chicago | Illinois | 60612-3806 | — |
| Cook County Hospital Core Center | Chicago | Illinois | 60612 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455-0392 | — |
| Washington University (St. Louis) | St Louis | Missouri | 63108-2138 | — |
| HIV Prevention & Treatment CRS | HVTN 722 West 168th Street MSPH Bldg. | New York | 10032 | — |
| Beth Israel Medical Center | New York | New York | 10003 | — |
| Cornell CRS | New York | New York | 10011 | — |
| NY Univ. HIV/AIDS CRS | New York | New York | 10016 | — |
| Community Health Network, Inc. | Rochester | New York | 14642-0001 | — |
| Univ. of Rochester ACTG CRS | Rochester | New York | 14642-0001 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27514 | — |
| Wake County Health and Human Services Clinical Research Site | Chapel Hill | North Carolina | 27514 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267-0405 | — |
| The Ohio State Univ. AIDS CRS | Columbus | Ohio | 43210 | — |
| Hosp. of the Univ. of Pennsylvania CRS | Philadelphia | Pennsylvania | 19104 | — |
| Stanley Street Treatment and Resource | Providence | Rhode Island | 02906 | — |
| The Miriam Hosp. ACTG CRS | Providence | Rhode Island | 02906 | — |
| Vanderbilt Therapeutics CRS | Nashville | Tennessee | 37204 | — |
| University of Texas, Southwestern Medical Center | Dallas | Texas | — | — |
| University of Texas, Galveston | Galveston | Texas | 77555-0435 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00084136, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 10, 2018 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00084136 live on ClinicalTrials.gov.