The Safety and Efficacy of Neramexane in Patients With Moderate to Severe Alzheimer's Disease
Public ClinicalTrials.gov record NCT00090116. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind,Placebo-Controlled Evaluation of the Safety and Efficacy of Neramexane Monotherapy in Patients With Moderate to Severe Dementia of the Alzheimer's Type
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Memory loss and difficulties with thinking associated with Alzheimer's disease may be due to chronic release of a brain chemical called glutamate. Glutamate helps transmit messages between nerve cells through interaction with a certain type of receptor (N-methyl-D-aspartate, NMDA) on the cell. Neramexane is a new drug that blocks the effects of excessive glutamate at the receptor (NMDA receptor antagonist).
Study identification
- NCT ID
- NCT00090116
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 400 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2003 (Type not available)
- Primary completion
- Mar 2005 (Actual)
- Completion
- Mar 2005 (Actual)
- Last update posted
- Mar 5, 2012
2003 – 2005
United States locations
- U.S. sites
- 34
- U.S. states
- 18
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pivotal Research Centers | Peoria | Arizona | 85381 | — |
| 21st Century Neurology | Phoenix | Arizona | 85013 | — |
| Margolin Brain Institute | Fresno | California | 93720 | — |
| Pharmacology Research Institute | Northridge | California | 91324 | — |
| UCI Medical Center | Orange | California | 92868 | — |
| Pacific Research Network | San Diego | California | 92103 | — |
| Affiliated Research Institute | San Diego | California | 92108 | — |
| University of Colorado Health Sciences Center | Denver | Colorado | 80262 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06510 | — |
| Baumel-Eisner Neuromedical Institute | Fort Lauderdale | Florida | 33321 | — |
| Berma Research Group | Hialeah | Florida | 33016 | — |
| Palm Beach Neurological Center | Palm Beach Gardens | Florida | 33410 | — |
| Neurology Clinical Research, Inc. | Plantation | Florida | 33324 | — |
| University of South Florida | Tampa | Florida | 33612 | — |
| Palm Beach Neurology | West Palm Beach | Florida | 33407 | — |
| Indiana Universisty Medical Center | Indianapolis | Indiana | 46202 | — |
| Lexington Clinic | Lexington | Kentucky | 40504 | — |
| J. Gary Booker, MD | Shreveport | Louisiana | 71101 | — |
| Mood and Memory Clinic of Michigan | Farmington Hills | Michigan | 48334 | — |
| St. Louis University | St Louis | Missouri | 63104 | — |
| Alzheimer's Research Corporation | Lakehurst | New Jersey | 08733 | — |
| Joel Ross, MD | Long Branch | New Jersey | 07740 | — |
| Ubhc/Umdnj | Piscataway | New Jersey | 08855 | — |
| Upstate Clinical Research | Albany | New York | 12205 | — |
| Nathan S. Kline Institute for Psychiatric Research | Orangeburg | New York | 10962 | — |
| Monroe Community Hospital | Rochester | New York | 14620 | — |
| Behavioral Medical Research of Saten Island, PC | Staten Island | New York | 10305 | — |
| Piedmont Medical Research | Winston-Salem | North Carolina | 27103 | — |
| Ohio State University | Columbus | Ohio | 443210 | — |
| Neurology and Neuroscience Center of Ohio | Toledo | Ohio | 43623 | — |
| Summit Research Network | Portland | Oregon | 97223 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29406 | — |
| North Texas Neurology Research | Wichita | Texas | 76301 | — |
| Pioneer Pharmaceutical Research | Midvale | Utah | 84047 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00090116, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 5, 2012 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00090116 live on ClinicalTrials.gov.