ClinicalTrials.gov record
Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function
ClinicalTrials.gov ID: NCT00094302
Public ClinicalTrials.gov record NCT00094302. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT)
Study identification
- NCT ID
- NCT00094302
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Carelon Research
- Other
- Enrollment
- 3,445 participants
Conditions and interventions
Interventions
- Spironolactone Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 31, 2006
- Primary completion
- May 31, 2013
- Completion
- May 31, 2013
- Last update posted
- Mar 1, 2015
2006 – 2013
United States locations
- U.S. sites
- 155
- U.S. states
- 39
- U.S. cities
- 123
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Cardiovascular Consultants, Ltd. | Glendale | Arizona | 85306 | — |
| Carl T. Hayden VA Medical Center | Phoenix | Arizona | 85012 | — |
| Central Arkansas Veterans Healthcare System | Little Rock | Arkansas | 72205 | — |
| Heart Clinic Arkansas | Little Rock | Arkansas | 72205 | — |
| Cynthia Thaik | Burbank | California | 91505 | — |
| Fresno VA Medical Center | Fresno | California | 93703 | — |
| Clinica Medica San Miguel | Los Angeles | California | 90015 | — |
| CAPRI | Los Angeles | California | 90048 | — |
| VA Medical Center West Los Angeles | Los Angeles | California | 90073 | — |
| Mehrdad Kevin Ariani, MD, Inc. | Northridge | California | 91325 | — |
| UC Davis Medical Center | Sacremento | California | 95829 | — |
| Central Coast Cardiology | Salinas | California | 93901 | — |
| Naval Medical Center San Diego | San Diego | California | 92134 | — |
| Olive View - UCLA Medial Center | Sylmar | California | 91342 | — |
| University of Colorado Health Sciences Center | Aurora | Colorado | 80045 | — |
| Cardio-Vascular Institute | Greeley | Colorado | 80631 | — |
| University of Connecticut Health Center | Farmington | Connecticut | 06030 | — |
| Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Howard University Hospital | Washington D.C. | District of Columbia | 20060' | — |
| Washington DC VA Hospital | Washington D.C. | District of Columbia | 20422 | — |
| Daytona Heart Group | Daytona Beach | Florida | 32114 | — |
| M & O Clinical Research, LLC | Fort Lauderdale | Florida | 33316 | — |
| Florida Heart Center | Ft. Pierce | Florida | 34950 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | — |
| Brevard Cardiovascular Research Associates, Inc | Rockledge | Florida | 37955 | — |
| Tallahassee Research Institute | Tallahassee | Florida | 32308 | — |
| Emory University at Grady Health System | Atlanta | Georgia | 30303 | — |
| Morehouse School of Medicine | Atlanta | Georgia | 30310 | — |
| Northside Cardiology Center | Atlanta | Georgia | 30342 | — |
| InnovaMed Alliance | Marietta | Georgia | 30060 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Illinois at Chicago Medical Center | Chicago | Illinois | 60612 | — |
| Northwestern University | Chicago | Illinois | 60657 | — |
| Cardiovascular Research Foundation | Elk Grove Village | Illinois | 60007 | — |
| Heart, Lung and Vascular Institute | Peoria | Illinois | 61606 | — |
| HeartCare Midwest | Peoria | Illinois | 61614 | — |
| The Care Group, LLC | Indianapolis | Indiana | 46260 | — |
| Cardiovascular Research of Northwest Indiana, LLC | Munster | Indiana | 46321 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| Baptist Healthcare System, Inc. d/b/a Baptist Hospital East | Louisville | Kentucky | 40207 | — |
| Leonard J. Chabert Medical Center | Houma | Louisiana | 70363 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Northeast Cardiology | Bangor | Maine | 04401 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | — |
| Kaiser Permanente | Largo | Maryland | 20774 | — |
| Northwest Hospital | Randallstown | Maryland | 21133 | — |
| Delmarva Heart Research Foundation | Salisbury | Maryland | 21804 | — |
| Associates in Cardiology, PA | Silver Spring | Maryland | 20910 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Boston University Medical Center | Boston | Massachusetts | 02118 | — |
| Caritas St. Elizabeth's Medical Center | Boston | Massachusetts | 02135 | — |
| Merrimack Valley Cardiology Associates | Chelmsford | Massachusetts | 01824 | — |
| Compass Medical East Bridgewater | East Bridgewater | Massachusetts | 02333 | — |
| Pentucket Medical Associates | Haverhill | Massachusetts | 01830 | — |
| Charles River Medical Associates | Natick | Massachusetts | 01760 | — |
| Hawthorn Medical Associates | North Dartmouth | Massachusetts | 02747 | — |
| Baystate Medical Center | Springfield | Massachusetts | 01199 | — |
| Umass Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| Veterans Affairs Ann Arbor Health Care System | Ann Arbor | Michigan | 48105 | — |
| Oakwood Hospital and Medical Center | Dearborn | Michigan | 48123 | — |
| Detroit VA Medical Center | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| William Beaumont Health Center | Royal Oak | Michigan | 48073 | — |
| Minneapolis VA Medical Center | Minneapolis | Minnesota | 55417 | — |
| Heartland Regional Medical Clinic | Saint Joseph | Missouri | 64506 | — |
| Glacier View Cardiology | Kalispell | Montana | 59901 | — |
| Bryan LGH Heart Institute | Lincoln | Nebraska | 68506 | — |
| The Creighton Cardiac Center | Omaha | Nebraska | 68131 | — |
| Deborah Heart and Lung Center | Browns Mills | New Jersey | 08015 | — |
| Cardiovascular Associates of the Delaware Valley | Elmer | New Jersey | 08318 | — |
| Cardiovascular Associates of the Delaware Valley | Haddon Heights | New Jersey | 08035 | — |
| NJ Heart | Linden | New Jersey | 07036 | — |
| St. Joseph's Regional Medical Center | Paterson | New Jersey | 07503 | — |
| The Valley Hospital | Ridgewood | New Jersey | 07450 | — |
| Electrophysiology Research Foundation | Somerset | New Jersey | 08873 | — |
| Community Medical Center | Toms River | New Jersey | 08755 | — |
| New Jersey Cardiology Associates | West Orange | New Jersey | 07052 | — |
| New York Methodist Hospital | Brooklyn | New York | 11215 | — |
| Research Foundation State University of New York at Buffalo | Buffalo | New York | 14203 | — |
| Buffalo Heart Group, LLC | Buffalo | New York | 14215 | — |
| Jamaica Hospital Medical Center | Jamaica | New York | 11418 | — |
| Mid Valley Cardiology | Kingston | New York | 12401 | — |
| Winthrop Cardiology Associates | Mineola | New York | 11501 | — |
| Soundshore Medical Center of Westchester | New Rochelle | New York | 10802 | — |
| NYU School of Medicine | New York | New York | 10016 | — |
| St. Lukes Roosevelt | New York | New York | 10019 | — |
| Northport VA Medical Center | Northport | New York | 11768 | — |
| University of Rochester Medical Center | Rochester | New York | 14618 | — |
| Lewin, Fagen, and Lown, MD, PC | Smithtown | New York | 11787 | — |
| SUNY Upstate Medical Center | Syracuse | New York | 13210 | — |
| Syracuse VA Medical Center | Syracuse | New York | 13210 | — |
| Bronx-Lebanon Hospital Center | The Bronx | New York | 10457 | — |
| Northeast Medical Center | Concord | North Carolina | 28025 | — |
| Durham VA Medical Center | Durham | North Carolina | 27705 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| The Lindner Clinical Trial Center | Cincinnati | Ohio | 45219 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| University Hospitals of Cleveland/Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | — |
| Ohio State University Hospital East | Columbus | Ohio | 43205 | — |
| VAMC Dayton | Dayton | Ohio | 45428 | — |
| CCHS Clinical Research Office/Marymount Hospital | Garfield Heights | Ohio | 44125 | — |
| CCHS Clinical Research Office/ Hillcrest Hospital | Mayfield Heights | Ohio | 44124 | — |
| COR Clinical Research | Oklahoma City | Oklahoma | 73103 | — |
| Oklahoma City VA Medical Center | Oklahoma City | Oklahoma | 73104 | — |
| Oklahoma Foundation for Cardiovascular Research | Oklahoma City | Oklahoma | 73210 | — |
| Oklahoma Heart Institute | Tulsa | Oklahoma | 74137 | — |
| St. Charles Health System | Bend | Oregon | 97701 | — |
| Providence Heart and Vascular Institute | Portland | Oregon | 97213 | — |
| Capital Area Research | Camp Hill | Pennsylvania | 17011 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Medicor Associates, Inc | Erie | Pennsylvania | 16507 | — |
| The Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Lancaster Heart and Stroke Foundation | Lancaster | Pennsylvania | 17603 | — |
| Drexel University College of Medicine | Philadelphia | Pennsylvania | 19102 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital- Dept. of Family and Community Health | Philadelphia | Pennsylvania | 19107 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Eastwick Primary Care | Philadelphia | Pennsylvania | 19153 | — |
| Pittsburgh VA Healthcare System | Pittsburgh | Pennsylvania | 15240 | — |
| The Reading Hospital and Medical Center | West Reading | Pennsylvania | 19611 | — |
| Memorial Hospital Rhode Island | Pawtucket | Rhode Island | 02860 | — |
| VAMC - Charleston, SC | Charleston | South Carolina | 29401 | — |
| Black Hills VA Health Care System | Fort Meade | South Dakota | 57741 | — |
| The Stern Cardiovascular Center | Germantown | Tennessee | 38138 | — |
| Memphis VA Medical Center | Memphis | Tennessee | 38104 | — |
| Memphis Heart Clinic | Memphis | Tennessee | 38120 | — |
| University of Tennessee Health Science Center | Memphis | Tennessee | 38163 | — |
| Vanderbilt Heart and Vascular Institute | Nashville | Tennessee | 37232 | — |
| DCT - APHC, LLC dba Discovery Clinical Trials | Arlington | Texas | 76014 | — |
| Dallas VA Medical Center | Dallas | Texas | 75216 | — |
| Cardiovascular Research Institute of Dallas | Dallas | Texas | 75231 | — |
| U.T. Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Michael E. DeBakey VA Medical Cntr. | Houston | Texas | 77030 | — |
| The Methodist Hospital Research Institute | Houston | Texas | 77030 | — |
| Wilford Hall Medical Center | Lackland City | Texas | 78236 | — |
| Texas Tech University Health Sciences Center | Odessa | Texas | 79763 | — |
| Cardiology Clinic of San Antonio | San Antonio | Texas | 78229 | — |
| Tyler Cardiovascular Consultants | Tyler | Texas | 75701 | — |
| LDS Hospital | Murray | Utah | 84157 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| Cardiovascular Associates Ltd. | Chesapeake | Virginia | 23320 | — |
| Sentara Cardiovascular Research Institute | Norfolk | Virginia | 23507 | — |
| Evergreen Healthcare | Kirkland | Washington | 98034 | — |
| Providence St. Peter Hospital | Olympia | Washington | 98506 | — |
| Sound Health Research | Port Orchard | Washington | 98366 | — |
| University of Washington | Seattle | Washington | 98195 | — |
| CAMC Health Education and Research Institute | Charleston | West Virginia | 25304 | — |
| William S. Middleton Memorial VA Hospital | Madison | Wisconsin | 53705 | — |
| University of Wisconsin-Madison | Madison | Wisconsin | 53792 | — |
| Aspirus Heart and Vascular Institute | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 115 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00094302, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 1, 2015 · Synced Jun 26, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00094302 live on ClinicalTrials.gov.