Radiation Therapy and Stereotactic Radiosurgery With or Without Temozolomide or Erlotinib in Treating Patients With Brain Metastases Secondary to Non-Small Cell Lung Cancer
Public ClinicalTrials.gov record NCT00096265. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Trial Comparing Whole Brain Radiation and Stereotactic Radiosurgery Alone Versus With Temozolomide or Erlotinib in Patients With Non-Small Cell Lung Cancer and 1-3 Brain Metastases
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase III trial is studying whole-brain radiation therapy and stereotactic radiosurgery with or without temozolomide or erlotinib to see how well they work compared to whole-brain radiation therapy and stereotactic radiosurgery in treating patients with brain metastases secondary to non-small cell lung cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Stereotactic radiosurgery may be able to deliver x-rays directly to the tumor and cause less damage to normal tissue. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop tumor cells from dividing so they stop growing or die. Erlotinib may stop the growth of tumor cells by blocking the enzymes necessary for their growth and by blocking blood flow to the tumor. It is not yet known whether radiation therapy and stereotactic radiosurgery are more effective with or without temozolomide or erlotinib in treating brain metastases.
Study identification
- NCT ID
- NCT00096265
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 126 participants
Conditions and interventions
Conditions
Interventions
- 3-Dimensional Conformal Radiation Therapy Radiation
- Erlotinib Hydrochloride Drug
- Stereotactic Radiosurgery Radiation
- Temozolomide Drug
Radiation · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 6, 2004 (Actual)
- Primary completion
- Jun 14, 2011 (Actual)
- Completion
- Apr 1, 2012 (Actual)
- Last update posted
- Mar 9, 2018
2004 – 2012
United States locations
- U.S. sites
- 80
- U.S. states
- 30
- U.S. cities
- 70
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Oncology Services Foundation | Scottsdale | Arizona | 85260 | — |
| Scottsdale Health Care-Osborn | Scottsdale | Arizona | 85260 | — |
| Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | 91505 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Pomona Valley Hospital Medical Center | Pomona | California | 91767 | — |
| Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | 81501 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| Baptist MD Anderson Cancer Center | Jacksonville | Florida | 32207 | — |
| Integrated Community Oncology Network-Southside Cancer Center | Jacksonville | Florida | 32207 | — |
| Baptist Medical Center South | Jacksonville | Florida | 32258 | — |
| Integrated Community Oncology Network-Florida Cancer Center Beaches | Jacksonville Beach | Florida | 32250 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| 21st Century Oncology-Orange Park | Orange Park | Florida | 32073 | — |
| UF Cancer Center at Orlando Health | Orlando | Florida | 32806 | — |
| 21st Century Oncology-Palatka | Palatka | Florida | 32177 | — |
| Bay Medical Center | Panama City | Florida | 32401 | — |
| Integrated Community Oncology Network-Flager Cancer Center | Saint Augustine | Florida | 32086 | — |
| Tallahassee Memorial HealthCare | Tallahassee | Florida | 32308 | — |
| John B Amos Cancer Center | Columbus | Georgia | 31904 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Northwest Community Hospital | Arlington Heights | Illinois | 60005 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| Saint John's Hospital | Springfield | Illinois | 62702 | — |
| Parkview Hospital Randallia | Fort Wayne | Indiana | 46805 | — |
| Franciscan Saint Margaret Health-Hammond Campus | Hammond | Indiana | 46320 | — |
| IU Health Methodist Hospital | Indianapolis | Indiana | 46202 | — |
| Finley Hospital | Dubuque | Iowa | 52001 | — |
| Norton Suburban Hospital and Medical Campus | Louisville | Kentucky | 40207 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Saint Agnes Hospital | Baltimore | Maryland | 21229 | — |
| Massachusetts General Hospital Cancer Center | Boston | Massachusetts | 02114 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Fairview-Southdale Hospital | Edina | Minnesota | 55435 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| University of Minnesota/Masonic Cancer Center | Minneapolis | Minnesota | 55455 | — |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | — |
| Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| Saint Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| Metro Minnesota Community Oncology Research Consortium | Saint Louis Park | Minnesota | 55416 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | — |
| Saint Louis University Hospital | St Louis | Missouri | 63110 | — |
| Nevada Cancer Research Foundation CCOP | Las Vegas | Nevada | 89106 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08903 | — |
| Riverview Medical Center/Booker Cancer Center | Red Bank | New Jersey | 07701 | — |
| Sparta Cancer Treatment Center | Sparta | New Jersey | 07871 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Mission Hospital-Memorial Campus | Asheville | North Carolina | 28801 | — |
| Summa Akron City Hospital/Cooper Cancer Center | Akron | Ohio | 44304 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Natalie Warren Bryant Cancer Center at Saint Francis | Tulsa | Oklahoma | 74136 | — |
| Delaware County Memorial Hospital | Drexel Hill | Pennsylvania | 19026 | — |
| Radiation Therapy Oncology Group | Philadelphia | Pennsylvania | 19103 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Thompson Cancer Survival Center | Knoxville | Tennessee | 37916 | — |
| Arlington Cancer Center | Arlington | Texas | 76012 | — |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555-0565 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| McKay-Dee Hospital Center | Ogden | Utah | 84403 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | 23298 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
| Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Wheaton Franciscan Cancer Care - All Saints | Racine | Wisconsin | 53405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00096265, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 9, 2018 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00096265 live on ClinicalTrials.gov.