Efficacy Study of MM-093 in Rheumatoid Arthritis Patients on Methotrexate (MTX)
Public ClinicalTrials.gov record NCT00105976. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Double-Blind, Parallel, Placebo-Controlled, Randomized Study to Evaluate the Efficacy and Safety of 3 Different Dose Levels (2.5, 7.5 and 20 mg) of MM-093 in Patients With Active Rheumatoid Arthritis on Stable Doses of Methotrexate
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this clinical study is to see if an experimental drug, called MM-093, is safe and effective in the treatment of rheumatoid arthritis. MM-093 is a genetically engineered version of a naturally occurring protein called alpha fetoprotein (AFP). Adults normally have very small amounts of AFP in their bloodstream. However, during pregnancy, AFP levels in both the mother and the fetus are much higher than normal. It has been observed that women with RA (Rheumatoid Arthritis) have fewer symptoms during pregnancy, particularly during the third trimester. At this time, the levels of AFP in the blood of the mother and fetus are the highest. This observation led researchers to begin examining AFP as a possible treatment for RA.
Study identification
- NCT ID
- NCT00105976
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 260 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 2005 (Type not available)
- Primary completion
- Not listed
- Completion
- Not listed
- Last update posted
- Jul 11, 2008
Started 2005
United States locations
- U.S. sites
- 38
- U.S. states
- 21
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama | Birmingham | Alabama | 35294 | — |
| Montgomery Rheumatology Associates | Montgomery | Alabama | 36111 | — |
| Arizona Arthritis Research, PLC | Paradise Valley | Arizona | 85253 | — |
| ArthroCare, Arthritis Care and Research, Inc. | Phoenix | Arizona | 85012 | — |
| Radiant Research | Scottsdale | Arizona | 85251 | — |
| Arthritis Medical Center of the Central Coast | Santa Maria | California | 93454 | — |
| Boling Clinical Trials | Upland | California | 91786 | — |
| National Jewish Medical and Research Center | Denver | Colorado | 80206 | — |
| Denver Arthritis Clinic | Denver | Colorado | 80230 | — |
| New England Research Associates | Bridgeport | Connecticut | 06606 | — |
| Arthritis and Rheumatic Disease Specialties | Aventura | Florida | 33180 | — |
| Renstar Medical Research | Ocala | Florida | 34471 | — |
| International Medical Research | Ormond Beach | Florida | 32174 | — |
| Sarasota Arthritis Research Center | Sarasota | Florida | 34239 | — |
| Center for Arthritis and Rheumatic Diseases | South Miami | Florida | 33143 | — |
| Coeur d'Alene Arthritis Clinic | Coeur d'Alene | Idaho | 83814 | — |
| Illinois Bone and Joint Institute | Morton Grove | Illinois | 60016 | — |
| The Arthritis Center | Springfield | Illinois | 62704 | — |
| Deerbrook Medical Associates | Vernon Hills | Illinois | 60061 | — |
| Rheumatology Associates, PC | Indianapolis | Indiana | 46260 | — |
| Wichita Clinic | Wichita | Kansas | 67208 | — |
| Rx Trials, Inc. | Columbia | Maryland | 21045 | — |
| Arthritis Center of Nebraska | Lincoln | Nebraska | 68516 | — |
| Arthritis Center of Reno | Reno | Nevada | 89502 | — |
| Arthritis, Osteoporosis & Musculoskeletal Disease Center | Concord | New Hampshire | 03301 | — |
| Arthritis Health Associates | Syracuse | New York | 13210 | — |
| Asheville Rheumatology and Osteoporosis Research Associates, Inc | Asheville | North Carolina | 28801 | — |
| Arthritis Clinic and Carolina Bone and Joint PA | Charlotte | North Carolina | 28210 | — |
| CARE Center | Raleigh | North Carolina | 27609 | — |
| North Carolina Arthritis and Allergy Care Center | Raleigh | North Carolina | 27609 | — |
| Veterans Administration Research Services | Cincinnati | Ohio | 45220 | — |
| Altoona Center for Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| Rheumatic Disease Associates | Willow Grove | Pennsylvania | 19090 | — |
| The Arthritis Group | Memphis | Tennessee | 38104 | — |
| Austin Rheumatology Research | Austin | Texas | 78705 | — |
| Houston Institute for Clinical Research | Houston | Texas | 77074 | — |
| Arthritis and Osteoporosis Clinic | Waco | Texas | 76708 | — |
| University of Utah Division of Rheumatology | Salt Lake City | Utah | 84132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00105976, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 11, 2008 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00105976 live on ClinicalTrials.gov.