ClinicalTrials.gov record
A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis Currently on Methotrexate Therapy
ClinicalTrials.gov ID: NCT00106522
Public ClinicalTrials.gov record NCT00106522. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind Study of Safety and Reduction in Signs and Symptoms During Treatment With Tocilizumab Versus Placebo, in Combination With Methotrexate, in Patients With Moderate to Severe Active Rheumatoid Arthritis and Inadequate Response to Anti-TNF Therapy
Study identification
- NCT ID
- NCT00106522
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Hoffmann-La Roche
- Industry
- Enrollment
- 499 participants
Conditions and interventions
Conditions
Interventions
- Methotrexate Drug
- Placebo Drug
- tocilizumab [RoActemra/Actemra] Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 30, 2005
- Primary completion
- Oct 31, 2007
- Completion
- Oct 31, 2007
- Last update posted
- Nov 1, 2016
2005 – 2007
United States locations
- U.S. sites
- 97
- U.S. states
- 36
- U.S. cities
- 84
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | Birmingham | Alabama | 35294 | — |
| Not listed | Huntsville | Alabama | 35801 | — |
| Not listed | Scottsdale | Arizona | 85251 | — |
| Not listed | Scottsdale | Arizona | 85258 | — |
| Not listed | Tucson | Arizona | 85724 | — |
| Not listed | Hot Springs | Arkansas | 71913 | — |
| Not listed | Little Rock | Arkansas | 72205 | — |
| Not listed | Anaheim | California | 92801 | — |
| Not listed | Fullerton | California | 92835 | — |
| Not listed | Long Beach | California | 90806 | — |
| Not listed | Long Beach | California | 90808 | — |
| Not listed | Los Angeles | California | 90095 | — |
| Not listed | Palm Desert | California | 92260 | — |
| Not listed | San Diego | California | 92101 | — |
| Not listed | San Diego | California | 92108 | — |
| Not listed | Santa Maria | California | 93454 | — |
| Not listed | Torrance | California | 90505 | — |
| Not listed | Colorado Springs | Colorado | 80910 | — |
| Not listed | Aventura | Florida | 33180 | — |
| Not listed | Boca Raton | Florida | 33486 | — |
| Not listed | Fort Lauderdale | Florida | 33334 | — |
| Not listed | Palm Habor | Florida | 34684 | — |
| Not listed | Sarasota | Florida | 34239 | — |
| Not listed | Tampa | Florida | 33614 | — |
| Not listed | Tavares | Florida | 32778 | — |
| Not listed | West Palm Beach | Florida | 33407 | — |
| Not listed | Zephyrhills | Florida | 33540 | — |
| Not listed | Atlanta | Georgia | 30342 | — |
| Not listed | Boise | Idaho | 83702 | — |
| Not listed | Meridian | Idaho | 83642 | — |
| Not listed | Chicago | Illinois | 60611 | — |
| Not listed | Springfield | Illinois | 62703 | — |
| Not listed | Springfield | Illinois | 62704 | — |
| Not listed | Indianapolis | Indiana | 46202-5100 | — |
| Not listed | Bowling Green | Kentucky | 42102 | — |
| Not listed | Elizabethtown | Kentucky | 42701 | — |
| Not listed | Lexington | Kentucky | 40515 | — |
| Not listed | Louisville | Kentucky | 40202 | — |
| Not listed | New Orleans | Louisiana | 70121 | — |
| Not listed | Portland | Maine | 04102 | — |
| Not listed | Baltimore | Maryland | 21201 | — |
| Not listed | Baltimore | Maryland | 21205 | — |
| Not listed | Wheaton | Maryland | 20902 | — |
| Not listed | Springfield | Massachusetts | 01107 | — |
| Not listed | Worcester | Massachusetts | 01605 | — |
| Not listed | Lansing | Michigan | 48910 | — |
| Not listed | Duluth | Minnesota | 55805 | — |
| Not listed | Rochester | Minnesota | 55905 | — |
| Not listed | Tupelo | Mississippi | 38802 | — |
| Not listed | St Louis | Missouri | 63110 | — |
| Not listed | St Louis | Missouri | 63128 | — |
| Not listed | St Louis | Missouri | 63131 | — |
| Not listed | St Louis | Missouri | 63141 | — |
| Not listed | Billings | Montana | 59107-5100 | — |
| Not listed | Missoula | Montana | 59802 | — |
| Not listed | Las Vegas | Nevada | 89119 | — |
| Not listed | Medford | New Jersey | 08055 | — |
| Not listed | Mercerville | New Jersey | 08619 | — |
| Not listed | Teaneck | New Jersey | 07666 | — |
| Not listed | Albany | New York | 12206 | — |
| Not listed | Binghamton | New York | 13905 | — |
| Not listed | Great Neck | New York | 11020 | — |
| Not listed | Johnson City | New York | 13790 | — |
| Not listed | New York | New York | 10003 | — |
| Not listed | New York | New York | 10021 | — |
| Not listed | Orchard Park | New York | 14127 | — |
| Not listed | Rochester | New York | 14618 | — |
| Not listed | Asheville | North Carolina | 28801 | — |
| Not listed | Chapel Hill | North Carolina | 27599-7280 | — |
| Not listed | Charlotte | North Carolina | 28210 | — |
| Not listed | Wilmington | North Carolina | 28401 | — |
| Not listed | Bismarck | North Dakota | 58501 | — |
| Not listed | Canton | Ohio | 44718 | — |
| Not listed | Cincinnati | Ohio | 45219 | — |
| Not listed | Oklahoma City | Oklahoma | 73103 | — |
| Not listed | Tulsa | Oklahoma | 74104 | — |
| Not listed | Tulsa | Oklahoma | 74135 | — |
| Not listed | Eugene | Oregon | 97401 | — |
| Not listed | Bala-Cynwyd | Pennsylvania | 19004 | — |
| Not listed | Danville | Pennsylvania | 17822 | — |
| Not listed | Duncansville | Pennsylvania | 16635 | — |
| Not listed | Philadelphia | Pennsylvania | 19140 | — |
| Not listed | Philadelphia | Pennsylvania | 19152 | — |
| Not listed | Willow Grove | Pennsylvania | 80045 | — |
| Not listed | Hickory Grove | South Carolina | 28602 | — |
| Not listed | Jackson | Tennessee | 38305 | — |
| Not listed | Austin | Texas | 78705 | — |
| Not listed | Dallas | Texas | 75231-4406 | — |
| Not listed | Dallas | Texas | 75231 | — |
| Not listed | Houston | Texas | 77074 | — |
| Not listed | Ogden | Utah | 84403 | — |
| Not listed | Norfolk | Virginia | 23502 | — |
| Not listed | Richmond | Virginia | 23298 | — |
| Not listed | Salem | Virginia | 24153 | — |
| Not listed | Seattle | Washington | 98104 | — |
| Not listed | Seattle | Washington | 98195 | — |
| Not listed | Glendale | Wisconsin | 53217 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 71 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00106522, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 1, 2016 · Synced May 1, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00106522 live on ClinicalTrials.gov.