A Study to Assess the Effect of Tocilizumab + Methotrexate on Prevention of Structural Joint Damage in Patients With Moderate to Severe Active Rheumatoid Arthritis (RA)
Public ClinicalTrials.gov record NCT00106535. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind Study of Safety and Prevention of Structural Joint Damage During Treatment With Tocilizumab Versus Placebo, in Combination With Methotrexate, in Patients With Moderate to Severe Rheumatoid Arthritis
Study identification
- NCT ID
- NCT00106535
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Hoffmann-La Roche
- Industry
- Enrollment
- 1,196 participants
Conditions and interventions
Conditions
Interventions
- Methotrexate Drug
- Placebo Drug
- tocilizumab [RoActemra/Actemra] Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 31, 2004
- Primary completion
- Apr 30, 2007
- Completion
- Jun 30, 2012
- Last update posted
- Feb 5, 2014
2005 – 2012
United States locations
- U.S. sites
- 61
- U.S. states
- 26
- U.S. cities
- 60
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | Birmingham | Alabama | 35233-7333 | — |
| Not listed | Huntsville | Alabama | 35801 | — |
| Not listed | Scottsdale | Arizona | 85251 | — |
| Not listed | Tucson | Arizona | 85724 | — |
| Not listed | Anaheim | California | 92801 | — |
| Not listed | Long Beach | California | 90806 | — |
| Not listed | Los Angeles | California | 90095 | — |
| Not listed | San Diego | California | 92108 | — |
| Not listed | San Francisco | California | 94118 | — |
| Not listed | Santa Maria | California | 93454 | — |
| Not listed | Torrance | California | 90505 | — |
| Not listed | Boulder | Colorado | 80304 | — |
| Not listed | Colorado Springs | Colorado | 80910 | — |
| Not listed | Denver | Colorado | 80230 | — |
| Not listed | Aventura | Florida | 33180 | — |
| Not listed | Fort Lauderdale | Florida | 33334 | — |
| Not listed | Tampa | Florida | 33614 | — |
| Not listed | West Palm Beach | Florida | 33407 | — |
| Not listed | Boise | Idaho | 83702 | — |
| Not listed | Coeur d'Alene | Idaho | 83814 | — |
| Not listed | Idaho Falls | Idaho | 83404 | — |
| Not listed | Meridan | Idaho | 83642 | — |
| Not listed | Chicago | Illinois | 60612-3824 | — |
| Not listed | Rockford | Illinois | 61103 | — |
| Not listed | Indianapolis | Indiana | 46202-5100 | — |
| Not listed | Lexington | Kentucky | 40515 | — |
| Not listed | Frederick | Maryland | 21702 | — |
| Not listed | Hagerstown | Maryland | 21740 | — |
| Not listed | Wheaton | Maryland | 20902 | — |
| Not listed | St Louis | Missouri | 63131 | — |
| Not listed | St Louis | Missouri | 63141 | — |
| Not listed | Billings | Montana | 59101 | — |
| Not listed | Missoula | Montana | 59802 | — |
| Not listed | Reno | Nevada | 89502 | — |
| Not listed | Dover | New Hampshire | 03820 | — |
| Not listed | Medford | New Jersey | 08055 | — |
| Not listed | Voorhees Township | New Jersey | 08043 | — |
| Not listed | Albany | New York | 12206 | — |
| Not listed | Brooklyn | New York | 11201 | — |
| Not listed | Lake Success | New York | 11042 | — |
| Not listed | New York | New York | 10016 | — |
| Not listed | Stony Brook | New York | 11794-8161 | — |
| Not listed | Asheville | North Carolina | 28801 | — |
| Not listed | Charlotte | North Carolina | 28211 | — |
| Not listed | Raleigh | North Carolina | 27609 | — |
| Not listed | Wilmington | North Carolina | 28401 | — |
| Not listed | Canton | Ohio | 44718 | — |
| Not listed | Oklahoma City | Oklahoma | 73109 | — |
| Not listed | Tulsa | Oklahoma | 74135 | — |
| Not listed | Eugene | Oregon | 97401 | — |
| Not listed | Bethlehem | Pennsylvania | 18015 | — |
| Not listed | Duncansville | Pennsylvania | 16635 | — |
| Not listed | Philadelphia | Pennsylvania | 19140 | — |
| Not listed | Wyomissing | Pennsylvania | 19610 | — |
| Not listed | Columbia | South Carolina | 29204 | — |
| Not listed | Nashville | Tennessee | 37203 | — |
| Not listed | Dallas | Texas | 75231 | — |
| Not listed | San Antonio | Texas | 78217 | — |
| Not listed | Olympia | Washington | 98502 | — |
| Not listed | Seattle | Washington | 98104 | — |
| Not listed | Glendale | Wisconsin | 53217 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 91 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00106535, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 5, 2014 · Synced May 16, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00106535 live on ClinicalTrials.gov.