Efficacy and Safety of Topical Diclofenac Combined With Oral Diclofenac in the Treatment of Knee Osteoarthritis
Public ClinicalTrials.gov record NCT00108992. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Oral non-steroidal anti-inflammatory drugs (NSAIDs) are a recommended treatment for the symptoms of osteoarthritis of the knee. However, NSAIDs may cause a range of negative side effects, including stomach pain, heartburn, bleeding stomach ulcer, and liver or kidney abnormality. A topical NSAID may relieve pain and other symptoms of osteoarthritis of the knee, while minimizing the side effects common to oral NSAIDs. The purpose of this study is to determine the safety and effectiveness of a topical NSAID when used alone or when combined with an oral NSAID in the treatment of osteoarthritis of the knee.
Study identification
- NCT ID
- NCT00108992
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 750 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 2004 (Type not available)
- Primary completion
- Not listed
- Completion
- Sep 2005 (Type not available)
- Last update posted
- Jan 5, 2007
2004 – 2005
United States locations
- U.S. sites
- 22
- U.S. states
- 13
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Coastal Clinical Research | Mobile | Alabama | 36608 | — |
| Redpoint Research | Phoenix | Arizona | 85029 | — |
| OMC Clinical | Beverly Hills | California | 90211 | — |
| Associated Pharmaceutical Research | Buena Park | California | 90620 | — |
| Med Investigators | Fair Oaks | California | 95628 | — |
| Desert Medical Advances | Palm Desert | California | 92260 | — |
| Boling Clinical Trials | Upland | California | 91786 | — |
| Tampa Bay Medical Research Inc. | Clearwater | Florida | 33761 | — |
| Palm Beach Research Center | West Palm Beach | Florida | 33409 | — |
| Medisphere Medical Research | Evansville | Indiana | 47714 | — |
| Synergy Medical Education Alliance | Saginaw | Michigan | 48602 | — |
| Redrock Research Center | Las Vegas | Nevada | 89146 | — |
| Partners in Primary Care | Voorhees Township | New Jersey | 08043 | — |
| Camp Hill Clinical Research Center | Camp Hill | Pennsylvania | 17011 | — |
| Primary Physicians Research | Pittsburgh | Pennsylvania | 15241 | — |
| University Orthopedics Center | State College | Pennsylvania | 16801 | — |
| Omega Medical Research | Warwick | Rhode Island | 02886 | — |
| Clinical Research Associates | Nashville | Tennessee | 37203 | — |
| Research Across America | Dallas | Texas | 75234 | — |
| Sam Clinical Research Center | San Antonio | Texas | 78229 | — |
| Hamptom Roads Center for Clinical Research | Norfolk | Virginia | 23502-9921 | — |
| National Clinical Research | Richmond | Virginia | 23294 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00108992, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 5, 2007 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00108992 live on ClinicalTrials.gov.