ClinicalTrials.gov record
Carboplatin and Paclitaxel With or Without Sorafenib Tosylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery
ClinicalTrials.gov ID: NCT00110019
Public ClinicalTrials.gov record NCT00110019. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Randomized, Placebo-Controlled Phase III Trial of Carboplatin, Paclitaxel and Sorafenib Versus Carboplatin, Paclitaxel and Placebo in Patients With Unresectable Locally Advanced or Stage IV Melanoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase III trial studies carboplatin, paclitaxel, and sorafenib tosylate to see how well they work compared to carboplatin and paclitaxel in treating patients with stage III or stage IV melanoma that cannot be removed by surgery. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. It is not yet known whether giving carboplatin and paclitaxel together with sorafenib tosylate is more effective than carboplatin and paclitaxel in treating melanoma.
Study identification
- NCT ID
- NCT00110019
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 823 participants
Conditions and interventions
Conditions
Interventions
- Carboplatin Drug
- Laboratory Biomarker Analysis Other
- Paclitaxel Drug
- Pharmacological Study Other
- Placebo Other
- Sorafenib Tosylate Drug
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2005 (Type not available)
- Primary completion
- Jan 2011 (Actual)
- Completion
- Aug 2012 (Actual)
- Last update posted
- Oct 19, 2015
2005 – 2012
United States locations
- U.S. sites
- 218
- U.S. states
- 40
- U.S. cities
- 178
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | — |
| Mercy Hospital Fort Smith | Fort Smith | Arkansas | 72903 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | 91505 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| Marin Cancer Care Inc | Greenbrae | California | 94904 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Bay Area Tumor Institute | Oakland | California | 94609 | — |
| Saint Joseph Hospital - Orange | Orange | California | 92868 | — |
| Stanford Cancer Institute | Palo Alto | California | 94304 | — |
| Kaiser Permanente-Redwood City | Redwood City | California | 94063 | — |
| Kaiser Permanente-Richmond | Richmond | California | 94801 | — |
| Kaiser Permanente-Roseville | Roseville | California | 95661 | — |
| Kaiser Permanente - Sacramento | Sacramento | California | 95825 | — |
| Kaiser Permanente-San Diego Mission | San Diego | California | 92108 | — |
| Veterans Administration-San Diego Medical Center | San Diego | California | 92161 | — |
| Kaiser Permanente-San Francisco | San Francisco | California | 94115 | — |
| California Pacific Medical Center-Pacific Campus | San Francisco | California | 94118 | — |
| Kaiser Permanente-Santa Teresa-San Jose | San Jose | California | 95119 | — |
| Santa Rosa Memorial Hospital | Sana Rosa | California | 95405 | — |
| Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | 95051 | — |
| Kaiser Permanente-Santa Rosa | Santa Rosa | California | 95403 | — |
| Kaiser Permanente-Vallejo | Vallejo | California | 94589 | — |
| The Medical Center of Aurora | Aurora | Colorado | 80012 | — |
| Boulder Community Hospital | Boulder | Colorado | 80301 | — |
| Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | 80907 | — |
| Porter Adventist Hospital | Denver | Colorado | 80210 | — |
| Exempla Saint Joseph Hospital | Denver | Colorado | 80218 | — |
| Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | 80218 | — |
| Swedish Medical Center | Englewood | Colorado | 80113 | — |
| Sky Ridge Medical Center | Lone Tree | Colorado | 80124 | — |
| Longmont United Hospital | Longmont | Colorado | 80501 | — |
| North Suburban Medical Center | Thornton | Colorado | 80229 | — |
| Hartford Hospital | Hartford | Connecticut | 06102 | — |
| Yale University | New Haven | Connecticut | 06520 | — |
| Beebe Medical Center | Lewes | Delaware | 19958 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | — |
| Broward Health Medical Center | Fort Lauderdale | Florida | 33316 | — |
| Southwest Florida Regional Medical Center | Fort Meyers | Florida | 33901 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida | 33021 | — |
| Baptist Cancer Institute | Jacksonville | Florida | 32207 | — |
| Jupiter Medical Center | Jupiter | Florida | 33458 | — |
| Lakeland Regional Cancer Center | Lakeland | Florida | 33805 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| Florida Hospital Orlando | Orlando | Florida | 32803 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Phoebe Putney Memorial Hospital | Albany | Georgia | 31701 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Atlanta Regional CCOP | Atlanta | Georgia | 30342 | — |
| Dekalb Medical Center | Decatur | Georgia | 30033 | — |
| Northeast Georgia Medical Center | Gainesville | Georgia | 30501 | — |
| Medical Center of Central Georgia | Macon | Georgia | 31208 | — |
| Southern Regional Medical Center | Riverdale | Georgia | 30274 | — |
| South Georgia Medical Center | Valdosta | Georgia | 31603 | — |
| University of Hawaii Cancer Center | Honolulu | Hawaii | 96813 | — |
| Swedish Covenant Hospital | Chicago | Illinois | 60625 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Advocate Sherman Hospital | Elgin | Illinois | 60123 | — |
| NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | 60201 | — |
| Hinsdale Hematology Oncology Associates Incorporated | Hinsdale | Illinois | 60521 | — |
| Trinity Medical Center | Moline | Illinois | 61265 | — |
| Memorial Medical Center | Springfield | Illinois | 62781 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Carle Clinic-Urbana Main | Urbana | Illinois | 61801 | — |
| IU Health Bloomington | Bloomington | Indiana | 47403 | — |
| Fort Wayne Medical Oncology and Hematology Inc-Parkview | Fort Wayne | Indiana | 46845 | — |
| Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| Franciscan Saint Anthony Health-Michigan City | Michigan City | Indiana | 46360 | — |
| Saint Joseph Regional Medical Center-Mishawaka | Mishawaka | Indiana | 46545 | — |
| Memorial Hospital of South Bend | South Bend | Indiana | 46601 | — |
| Physicians' Clinic of Iowa PC | Cedar Rapids | Iowa | 52402 | — |
| Cedar Rapids Oncology Association | Cedar Rapids | Iowa | 52403 | — |
| Heartland Oncology and Hematology LLP | Council Bluffs | Iowa | 51503 | — |
| Genesis Medical Center - East Campus | Davenport | Iowa | 52803 | — |
| Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | 50309 | — |
| Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | 50314 | — |
| University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | 52242 | — |
| Cedar Valley Medical Specialists | Waterloo | Iowa | 50701 | — |
| Cancer Center of Kansas - Chanute | Chanute | Kansas | 66720 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| Kansas City CCOP | Prairie Village | Kansas | 66208 | — |
| Salina Regional Health Center | Salina | Kansas | 67401 | — |
| Cancer Center of Kansas - Wellington | Wellington | Kansas | 67152 | — |
| Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas - Main Office | Wichita | Kansas | 67214 | — |
| Central Maine Medical Center | Lewiston | Maine | 04240 | — |
| Greater Baltimore Medical Center | Baltimore | Maryland | 21204 | — |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | — |
| MedStar Franklin Square Medical Center/Weinberg Cancer Institute | Baltimore | Maryland | 21237 | — |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | 21287 | — |
| Frederick Memorial Hospital | Frederick | Maryland | 21701 | — |
| Massachusetts General Hospital Cancer Center | Boston | Massachusetts | 02114 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Commonwealth Hematology Oncology PC-Worcester | Worcester | Massachusetts | 01605 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48106-0995 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Oakwood Hospital and Medical Center | Dearborn | Michigan | 48124 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Saint John Hospital and Medical Center | Detroit | Michigan | 48236 | — |
| Hurley Medical Center | Flint | Michigan | 48502 | — |
| Grand Rapids Clinical Oncology Program | Grand Rapids | Michigan | 49503 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | 48073 | — |
| Oncology Care Associates PLLC | Saint Joseph | Michigan | 49085 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| Saint John Macomb-Oakland Hospital | Warren | Michigan | 48093 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Saint Francis Regional Medical Center | Shakopee | Minnesota | 55379 | — |
| Minnesota Oncology and Hematology PA-Woodbury | Woodbury | Minnesota | 55125 | — |
| Singing River Hospital | Pascagoula | Mississippi | 39581 | — |
| Freeman Health System | Joplin | Missouri | 64804 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | — |
| Center for Cancer Care and Research | St Louis | Missouri | 63141 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Saint Louis-Cape Girardeau CCOP | St Louis | Missouri | 63141 | — |
| Montana Cancer Consortium NCORP | Billings | Montana | 59101 | — |
| Frontier Cancer Center and Blood Institute-Billings | Billings | Montana | 59102 | — |
| Nevada Cancer Research Foundation CCOP | Las Vegas | Nevada | 89106 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Veterans Adminstration New Jersey Health Care System | East Orange | New Jersey | 07018-1095 | — |
| Hackensack University Medical CCOP | Hackensack | New Jersey | 07601 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Hematology Oncology Associates of Central New York-East Syracuse | East Syracuse | New York | 13057 | — |
| Glens Falls Hospital | Glens Falls | New York | 12801 | — |
| Laura and Issac Perlmutter Cancer Center at NYU Langone | New York | New York | 10016 | — |
| MidHudson Regional Hospital of Westchester Medical Center | Poughkeepsie | New York | 12601 | — |
| Interlakes Foundation Inc-Rochester | Rochester | New York | 14623 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Stony Brook University Medical Center | Stony Brook | New York | 11794 | — |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | — |
| Montefiore Medical Center-Wakefield Campus | The Bronx | New York | 10466 | — |
| Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina | 28203 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Wayne Memorial Hospital | Goldsboro | North Carolina | 27534 | — |
| East Carolina University | Greenville | North Carolina | 27858 | — |
| Mid Dakota Clinic | Bismarck | North Dakota | 58501 | — |
| Sanford Medical Center-Fargo | Fargo | North Dakota | 58122 | — |
| Altru Cancer Center | Grand Forks | North Dakota | 58201 | — |
| Summa Akron City Hospital/Cooper Cancer Center | Akron | Ohio | 44304 | — |
| Mercy Medical Center | Canton | Ohio | 44708 | — |
| Aultman Health Foundation | Canton | Ohio | 44710 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| The Christ Hospital | Cincinnati | Ohio | 45219 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Columbus CCOP | Columbus | Ohio | 43215 | — |
| Grant Medical Center | Columbus | Ohio | 43215 | — |
| Mount Carmel Health Center West | Columbus | Ohio | 43222 | — |
| Doctors Hospital | Columbus | Ohio | 43228 | — |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | — |
| Cleveland Clinic Cancer Center Independence | Independence | Ohio | 44131 | — |
| Saint Rita's Medical Center | Lima | Ohio | 45801 | — |
| Licking Memorial Hospital | Newark | Ohio | 43055 | — |
| Springfield Regional Medical Center | Springfield | Ohio | 45505 | — |
| Cleveland Clinic Wooster Specialty Center | Wooster | Ohio | 44691 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Cancer Care Associates | Oklahoma City | Oklahoma | 73120 | — |
| Western Oncology Research Consortium | Portland | Oregon | 97213 | — |
| Kaiser Permanente | Portland | Oregon | 97227 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Delaware County Memorial Hospital | Drexel Hill | Pennsylvania | 19026 | — |
| Oncology Hematology Associates of Northern Pennsylvania | DuBois | Pennsylvania | 15801 | — |
| PinnacleHealth Cancer Center-Community Campus | Harrisburg | Pennsylvania | 17109 | — |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| Saint Mary Medical and Regional Cancer Center | Langhorne | Pennsylvania | 19047 | — |
| University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | — |
| Pennsylvania Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | 15232 | — |
| Pottstown Memorial Medical Center | Pottstown | Pennsylvania | 19464 | — |
| Hematology and Oncology Associates of North East Pennsylvania | Scranton | Pennsylvania | 18508 | — |
| Scranton Hematology Oncology | Scranton | Pennsylvania | 18510 | — |
| Geisinger Medical Group | State College | Pennsylvania | 16801 | — |
| Chester County Hospital | West Chester | Pennsylvania | 19380 | — |
| Jennersville Regional Hospital | West Grove | Pennsylvania | 19390 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| WellSpan Health-York Hospital | York | Pennsylvania | 17405 | — |
| Kent County Hospital | Warwick | Rhode Island | 02886 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| McLeod Regional Medical Center | Florence | South Carolina | 29506 | — |
| Rapid City Regional Hospital | Rapid City | South Dakota | 57701 | — |
| Sanford Cancer Center-Oncology Clinic | Sioux Falls | South Dakota | 57104 | — |
| Erlanger Medical Center | Chattanooga | Tennessee | 37403 | — |
| East Tennessee Baptist Hospital-Mercy Health Partners | Knoxville | Tennessee | 37920 | — |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| University of Vermont College of Medicine | Burlington | Vermont | 05405 | — |
| Martha Jefferson Hospital | Charlottesville | Virginia | 22901 | — |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | — |
| Danville Regional Medical Center | Danville | Virginia | 24541 | — |
| Virginia Oncology Associates-Hampton | Hampton | Virginia | 23666 | — |
| Group Health Cooperative-Seattle | Seattle | Washington | 98112 | — |
| Swedish Medical Center-First Hill | Seattle | Washington | 98122-4307 | — |
| West Virginia University Charleston | Charleston | West Virginia | 25304 | — |
| Edwards Comprehensive Cancer Center | Huntington | West Virginia | 25701 | — |
| Saint Mary's Medical Center | Huntington | West Virginia | 25702 | — |
| West Virginia University Healthcare | Morgantown | West Virginia | 26506 | — |
| Fox Valley Hematology and Oncology | Appleton | Wisconsin | 54911 | — |
| Aurora Cancer Care-Southern Lakes | Elkhorn | Wisconsin | 53121 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| Dean Hematology and Oncology Clinic | Madison | Wisconsin | 53717 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
| Holy Family Memorial Hospital | Manitowoc | Wisconsin | 54221 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
| Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00110019, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 19, 2015 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00110019 live on ClinicalTrials.gov.