Study of Desmoteplase (International Nonproprietary Name [INN]) in Acute Ischemic Stroke (DIAS-2)
Public ClinicalTrials.gov record NCT00111852. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Prospective, Randomized, Double-blind, Placebo-controlled, Single Bolus, Multinational, Multi-center, Parallel Group, Dose-ranging Study of Desmoteplase (INN) in the Indication of Acute Stroke
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate desmoteplase (which is a manufactured protein derived from the saliva of the vampire bat) in dissolving clots that are blocking the flow of blood through one (or more) of the blood vessels supplying the brain, thereby reopening the blocked blood vessel and allowing blood to flow again in individuals suffering from ischemic stroke.
Study identification
- NCT ID
- NCT00111852
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 193 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 31, 2005
- Primary completion
- Feb 28, 2007
- Completion
- Not listed
- Last update posted
- Mar 19, 2012
Started 2005
United States locations
- U.S. sites
- 28
- U.S. states
- 17
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Neurological Institute, Dept. of Neurology | Birmingham | Alabama | 35209 | — |
| University of California Los Angeles Medical Center | Los Angeles | California | 90024-1777 | — |
| Brain Matters, Inc. | Delray Beach | Florida | 33445 | — |
| Melbourne Internal Medicine Associates (MIMA) | Melbourne | Florida | 32901-3182 | — |
| Holmes Regional Medical Center | Melbourne | Florida | 32901 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Parkview Hospital | Fort Wayne | Indiana | 46805-5410 | — |
| Indiana Neuroscience Institute | Indianapolis | Indiana | 46260 | — |
| Jewish Hospital Healthcare Services, Inc. | Louisville | Kentucky | 40202 | — |
| University of Louisville Hospital | Louisville | Kentucky | 40202 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Boston University Medical Center | Boston | Massachusetts | 02118 | — |
| Beth Israel Deaconess Medical Center (BIDMC) | Boston | Massachusetts | 02215 | — |
| Nevada Neurosciences Institute at Sunrise | Las Vegas | Nevada | 89109 | — |
| JFK Medical Center | Edison | New Jersey | 08818 | — |
| Presbyterian Hospital | Charlotte | North Carolina | 28233-3549 | — |
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| The Ohio State University Medical Center | Columbus | Ohio | 43210 | — |
| Erlanger Health System | Chattanooga | Tennessee | 37403 | — |
| University of Tennessee, College of Medicine | Chattanooga | Tennessee | 37404 | — |
| Saint Thomas Hospital | Nashville | Tennessee | 37205 | — |
| University of Texas, Southwestern Medical Center at Dallas | Dallas | Texas | 75390-8897 | — |
| The Methodist Hospital | Houston | Texas | 77030 | — |
| University of Utah Medical Center | Salt Lake City | Utah | 84132 | — |
| Winchester Medical Center | Winchester | Virginia | 22601 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 16 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00111852, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 19, 2012 · Synced Sep 25, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00111852 live on ClinicalTrials.gov.