A Study of the Safety and Efficacy of Nitric Oxide Reduction in Patients With Cardiogenic Shock After a Heart Attack
Public ClinicalTrials.gov record NCT00112281. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III International, Multi-Center, Prospective, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of Nitric Oxide Synthase Inhibition With Tilarginine Acetate Injection in Patients With Cardiogenic Shock Complicating Acute Myocardial Infarction, or the TRIUMPH Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Tilarginine Acetate Injection is a new type of drug that temporarily stops the body from making a bodily substance called nitric oxide. The body may produce excess nitric oxide following severe heart damage leading to shock. During a heart attack, and especially after a blocked artery causing the heart attack is reopened, a large amount of nitric oxide is released into the heart muscle and into the blood. Normally small amounts of nitric oxide are good for the heart and blood vessels. However, when released in large amounts, such as during a heart attack, it may be harmful, by adding to the damage of the heart attack and lowering the heart's ability to pump blood to the body. It may cause blood pressure to be lowered and reduce the amount of blood flow to the body's vital organs. This may interfere with the body's organs being able to do their work. If Tilarginine Acetate Injection can stop extra nitric oxide from being made, the performance of the heart and blood flow to the organs may get better, which may result in the improvement of symptoms. The purpose of this study (TRIUMPH) is to investigate the safety and effectiveness of Tilarginine Acetate Injection compared to placebo (an inactive fluid that has no effect on the body but looks exactly like the medication being studied). The study will help determine whether Tilarginine Acetate Injection, by temporarily lowering the amount of nitric oxide released into the vital organs can improve blood pressure and the blood flow to the body's organs.
Study identification
- NCT ID
- NCT00112281
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 658 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2005 (Type not available)
- Primary completion
- Not listed
- Completion
- Jan 2007 (Type not available)
- Last update posted
- Aug 4, 2006
2005 – 2007
United States locations
- U.S. sites
- 83
- U.S. states
- 33
- U.S. cities
- 71
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The Heart Group, PC | Mobile | Alabama | 36608 | — |
| Sparks Regional Medical Center | Fort Smith | Arizona | 72901 | — |
| Banner Baywood Heart Hospital | Mesa | Arizona | 85206 | — |
| Mayo Clinic Hospital | Phoenix | Arizona | 85043 | — |
| Central Arkansas Cardiovascular Research Group (CACRG) | Little Rock | Arkansas | 72205 | — |
| Los Angeles Cardiology Associates | Los Angeles | California | 90017 | — |
| University of Southern California, LAC + USC Medical Center | Los Angeles | California | 90033 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Stanford University School of Medicine | Palo Alto | California | 94305-5406 | — |
| Desert Cardiology | Rancho Mirage | California | 92270 | — |
| Mercy General Hospital | Sacramento | California | 95819 | — |
| South Denver Cardiology Associates, PC | Littleton | Colorado | 80120 | — |
| Christiana Care Health Services | Newark | Delaware | 19718 | — |
| Washington Hospital Center | Washington D.C. | District of Columbia | 20010-2975 | — |
| Florida Cardiovascular Research Center | Atlantis | Florida | 33462 | — |
| Watson Clinic, LLP | Lakeland | Florida | 33805 | — |
| Health First Clinical Research Institute | Melbourne | Florida | 32901 | — |
| University of Miami School of Medicine | Miami | Florida | 33136 | — |
| Mt. Sinai Medical Center | Miami | Florida | 33140 | — |
| Mediquest Research Group | Ocala | Florida | 34471 | — |
| Orlando Regional Medical Center | Orlando | Florida | 32806 | — |
| Cardiovascular Center of Sarasota | Sarasota | Florida | 34239 | — |
| Emory Crawford Long Hospital | Atlanta | Georgia | 30308 | — |
| John H. Stroger Jr. Hospital of Cook County | Chicago | Illinois | 60612 | — |
| Heart Care Midwest | Peoria | Illinois | 61603 | — |
| Trinity Medical Center | Rock Island | Illinois | 61201 | — |
| Parkview Research Center | Fort Wayne | Indiana | 46805 | — |
| Iowa Health, Des Moines | Des Moines | Iowa | 50309 | — |
| Iowa Heart Centre | Des Moines | Iowa | 50314 | — |
| University of Iowa Hospital | Iowa City | Iowa | 52242 | — |
| University of Kansas Hospital | Kansas City | Kansas | 66160 | — |
| University of Kentucky | Lexington | Kentucky | 40536-0200 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Northeast Cardiology Associates | Bangor | Maine | 04401 | — |
| Maine Medical Center | Portland | Maine | 04102 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Interventional Cardiovascular Research - Lahey Clinic | Burlington | Massachusetts | 01805 | — |
| University of Massachusetts Medical School | Worcester | Massachusetts | 01655 | — |
| Fallon Cardiology - St. Vincent Hospital | Worchester | Massachusetts | 01608 | — |
| University of Michigan Health Systems | Ann Arbor | Michigan | 48109-0311 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Spectrum Health Hospitals | Grand Rapids | Michigan | 49525 | — |
| Nisus Research at Northern Michigan Hospital | Petoskey | Michigan | 49770 | — |
| William Beaumont Hospital | Royal Oak | Michigan | 48073-6769 | — |
| St. Mary's Duluth Clinic Health System | Duluth | Minnesota | 55805 | — |
| Mayo Clinic Minnesota | Rochester | Minnesota | 55905 | — |
| Saint Louis University | St Louis | Missouri | 63110 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| BryanLGH Heart Institute | Lincoln | Nebraska | 68516 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-2265 | — |
| Cooper Health System | Camden | New Jersey | 08103 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| Lenox Hill Heart and Vascular Institute of New York | New York | New York | 10021 | — |
| Mount Sinai Medical Center | New York | New York | 10029 | — |
| Rochester Cardio-Pulmonary Group, P.C. | Rochester | New York | 14621 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Cardiology Associates of Schenectady | Schenectady | New York | 12309 | — |
| Mission Hospitals | Asheville | North Carolina | 28801 | — |
| UNC Chapel Hill | Chapel Hill | North Carolina | 27599-7075 | — |
| Sanger Clinic | Charlotte | North Carolina | 28203 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| LeBauer Cardiovascular Research | Greensboro | North Carolina | 27401 | — |
| Forsyth Medical Center | Winston-Salem | North Carolina | 27103 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| MidWest Cardiology Research Foundation | Columbus | Ohio | 43214 | — |
| The Oregon Clinic | Portland | Oregon | 97213-2281 | — |
| Providence Heart & Vascular Institute | Portland | Oregon | 97225 | — |
| The Heart Care Group | Allentown | Pennsylvania | 18106 | — |
| Penn State Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| Lancaster General Hospital | Lancaster | Pennsylvania | 17603 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Guthrie Clinic | Sayre | Pennsylvania | 18830 | — |
| The Miriam Hospital | Providence | Rhode Island | 02906 | — |
| South Carolina Heart Center | Columbia | South Carolina | 29204 | — |
| Johnson City Medical Center | Johnson City | Tennessee | 37601 | — |
| St. Thomas Cardiology Consultants | Nashville | Tennessee | 37205 | — |
| Ben Taub General Hospital, Baylor College of Medicine | Houston | Texas | 77030 | — |
| The Methodist Hospital | Houston | Texas | 77030 | — |
| University of Texas Medical School | Houston | Texas | 77030 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Fletcher Allen Healthcare | Burlington | Vermont | 05401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 19 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00112281, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 4, 2006 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00112281 live on ClinicalTrials.gov.