Pemetrexed Disodium, Carboplatin, and Radiation Therapy With or Without Cetuximab in Treating Patients With Stage III Non-Small Cell Lung Cancer
Public ClinicalTrials.gov record NCT00117962. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase II Study of Radiation Therapy, Pemetrexed and Carboplatin With or Without Cetuximab in Stage III Non-Small Cell Lung Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Pemetrexed disodium may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab may also make tumor cells more sensitive to radiation therapy. Giving pemetrexed disodium, carboplatin, and radiation therapy together with cetuximab may kill more tumor cells. PURPOSE: This randomized phase II trial is studying how well giving pemetrexed disodium and carboplatin together with radiation therapy with or without cetuximab works in treating patients with stage III non-small cell lung cancer that cannot be removed by surgery.
Study identification
- NCT ID
- NCT00117962
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 109 participants
Conditions and interventions
Conditions
Interventions
- cetuximab Biological
- carboplatin Drug
- pemetrexed disodium Drug
- radiation therapy Radiation
Biological · Drug · Radiation
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2005 (Type not available)
- Primary completion
- Mar 2009 (Actual)
- Completion
- Sep 2012 (Actual)
- Last update posted
- Oct 7, 2016
2005 – 2012
United States locations
- U.S. sites
- 71
- U.S. states
- 26
- U.S. cities
- 59
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arroyo Grande Community Hospital | Arroyo Grande | California | 93420 | — |
| Eden Medical Center | Castro Valley | California | 94546 | — |
| Saint Rose Hospital | Hayward | California | 94545 | — |
| Rebecca and John Moores UCSD Cancer Center | La Jolla | California | 92093-0658 | — |
| Highland General Hospital | Oakland | California | 94602 | — |
| Alta Bates Summit Medical Center - Summit Campus | Oakland | California | 94609 | — |
| CCOP - Bay Area Tumor Institute | Oakland | California | 94609 | — |
| Valley Care Medical Center | Pleasanton | California | 94588 | — |
| Doctors Medical Center - San Pablo Campus | San Pablo | California | 94806 | — |
| Bendheim Cancer Center at Greenwich Hospital | Greenwich | Connecticut | 06830 | — |
| Tunnell Cancer Center at Beebe Medical Center | Lewes | Delaware | 19958 | — |
| CCOP - Christiana Care Health Services | Newark | Delaware | 19713 | — |
| Sibley Memorial Hospital | Washington D.C. | District of Columbia | 20016 | — |
| Florida Hospital Cancer Institute at Florida Hospital Orlando | Orlando | Florida | 32803-1273 | — |
| Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | Savannah | Georgia | 31403-3089 | — |
| University of Chicago Cancer Research Center | Chicago | Illinois | 60637-1470 | — |
| Louis A. Weiss Memorial Hospital | Chicago | Illinois | 60640 | — |
| La Grange Memorial Hospital | La Grange | Illinois | 60525 | — |
| Fort Wayne Medical Oncology and Hematology | Fort Wayne | Indiana | 46815 | — |
| Hematology Oncology Associates of the Quad Cities | Bettendorf | Iowa | 52722 | — |
| Iowa Blood and Cancer Care | Cedar Rapids | Iowa | 52402 | — |
| St. Luke's Hospital | Cedar Rapids | Iowa | 52402 | — |
| Mercy Regional Cancer Center at Mercy Medical Center | Cedar Rapids | Iowa | 52403 | — |
| Holden Comprehensive Cancer Center at University of Iowa | Iowa City | Iowa | 52242-1002 | — |
| Greenebaum Cancer Center at University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Upper Chesapeake Medical Center | Bel Air | Maryland | 21014 | — |
| Union Hospital Cancer Program at Union Hospital | Elkton MD | Maryland | 21921 | — |
| Hudner Oncology Center at Saint Anne's Hospital - Fall River | Fall River | Massachusetts | 02721 | — |
| Saint Luke's Hospital | Chesterfield | Missouri | 63017 | — |
| Missouri Cancer Associates | Columbia | Missouri | 65201 | — |
| Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - Saint Louis | St Louis | Missouri | 63110 | — |
| St. Anthony's Cancer Center | St Louis | Missouri | 63128 | — |
| Missouri Baptist Cancer Center | St Louis | Missouri | 63131 | — |
| Arch Medical Services, Incorporated at Center for Cancer Care and Research | St Louis | Missouri | 63141 | — |
| Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center | Grand Island | Nebraska | 68803 | — |
| Callahan Cancer Center at Great Plains Regional Medical Center | North Platte | Nebraska | 69103 | — |
| UNMC Eppley Cancer Center at the University of Nebraska Medical Center | Omaha | Nebraska | 68198-6805 | — |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | — |
| CCOP - Nevada Cancer Research Foundation | Las Vegas | Nevada | 89106 | — |
| New Hampshire Oncology - Hematology, PA - Hooksett | Hooksett | New Hampshire | 03106 | — |
| Lakes Region General Hospital | Laconia | New Hampshire | 03246 | — |
| Elliot Regional Cancer Center at Elliot Hospital | Manchester | New Hampshire | 03103 | — |
| St. Joseph's Hospital and Medical Center | Paterson | New Jersey | 07503 | — |
| Cancer Institute of New Jersey at Cooper - Voorhees | Voorhees Township | New Jersey | 08043 | — |
| CCOP - Hematology-Oncology Associates of Central New York | East Syracuse | New York | 13057 | — |
| Charles R. Wood Cancer Center at Glens Falls Hospital | Glens Falls | New York | 12801 | — |
| Mount Sinai Medical Center | New York | New York | 10029 | — |
| SUNY Upstate Medical University Hospital | Syracuse | New York | 13210 | — |
| Veterans Affairs Medical Center - Syracuse | Syracuse | New York | 13210 | — |
| Mission Hospitals - Memorial Campus | Asheville | North Carolina | 28801 | — |
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill | North Carolina | 27599-7295 | — |
| Duke Comprehensive Cancer Center | Durham | North Carolina | 27710 | — |
| Wayne Memorial Hospital, Incorporated | Goldsboro | North Carolina | 27534 | — |
| Pardee Memorial Hospital | Hendersonville | North Carolina | 28791 | — |
| Kinston Medical Specialists | Kinston | North Carolina | 28501 | — |
| FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center | Pinehurst | North Carolina | 28374 | — |
| Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center | Columbus | Ohio | 43210-1240 | — |
| Oklahoma University Cancer Institute | Oklahoma City | Oklahoma | 73104 | — |
| Cancer Care Associates - Mercy Campus | Oklahoma City | Oklahoma | 73120 | — |
| Rhode Island Hospital Comprehensive Cancer Center | Providence | Rhode Island | 02903 | — |
| Miriam Hospital | Providence | Rhode Island | 02906 | — |
| Roper St. Francis Cancer Center at Roper Hospital | Charleston | South Carolina | 29401 | — |
| McLeod Regional Medical Center | Florence | South Carolina | 29501 | — |
| Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center | Kingsport | Tennessee | 37662 | — |
| Mountainview Medical | Berlin Corners | Vermont | 05602 | — |
| Fletcher Allen Health Care - University Health Center Campus | Burlington | Vermont | 05401 | — |
| Danville Regional Medical Center | Danville | Virginia | 24541 | — |
| Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County | Martinsville | Virginia | 24115 | — |
| Southwest Virginia Regional Cancer Center at Wellmonth Health | Norton | Virginia | 24273 | — |
| Virginia Commonwealth University Massey Cancer Center | Richmond | Virginia | 23298-0037 | — |
| St. Mary's Regional Cancer Center at St. Mary's Medical Center | Huntington | West Virginia | 25702 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00117962, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 7, 2016 · Synced Nov 2, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00117962 live on ClinicalTrials.gov.