Efficacy of 400 Mg Versus 800 Mg Imatinib in Chronic Myeloid Leukemia in Chronic Phase Patients - TOPS (Tyrosine Kinase Inhibitor Optimization and Selectivity)
Public ClinicalTrials.gov record NCT00124748. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Open-label Study of 400 mg Versus 800 mg of Imatinib Mesylate in Patients With Newly Diagnosed, Previously Untreated Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Using Molecular Endpoints.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study investigated the safety and efficacy of 400mg Versus 800mg imatinib in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase (CML-CP) using molecular endpoints.
Study identification
- NCT ID
- NCT00124748
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 476 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2005 (Type not available)
- Primary completion
- Nov 2010 (Actual)
- Completion
- Nov 2010 (Actual)
- Last update posted
- Feb 3, 2012
2005 – 2010
United States locations
- U.S. sites
- 50
- U.S. states
- 24
- U.S. cities
- 38
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of South Alabama | Mobile | Alabama | 36693 | — |
| Alta Bates Comprehsenive Cancer Center | Berkeley | California | 94704 | — |
| University of Miami | Berkeley | California | 94704 | — |
| South Bay Oncology Hematology Partners | Campbell | California | 95008 | — |
| UCLA Medical Center | Los Angeles | California | 90095 | — |
| Rocky Mountain Cancer Center | Denver | Colorado | 80218 | — |
| Osler Medical Inc. | Melbourne | Florida | 32901 | — |
| Advanced Medical Specialists | Miami | Florida | 33176 | — |
| Integrated Community Oncology Network | Orange Park | Florida | 32073 | — |
| Hematology-Oncology Associates, P.A. | Pensacola | Florida | 32501 | — |
| Palm Beach Cancer Institute | West Palm Beach | Florida | 233401 | — |
| Palm Beach Cancer Institute | West Palm Beach | Florida | 33401 | — |
| Cancer Research Center of Hawaii | Honolulu | Hawaii | 96813 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Indiana Blood and Marrow Institutw | Beech Grove | Indiana | 46107 | — |
| Indiana Blood and Marrow Transplant | Beech Grove | Indiana | 46107 | — |
| University of Iowa Hospitals & Clinic | Iowa City | Iowa | 52242 | — |
| University of Kentucky - C201 Clinic | Lexington | Kentucky | 40536 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Lousville Oncology, Clinical Research Program M-25 | Louisville | Kentucky | 40202 | — |
| Jayne S. Gurtler, MD, Laura A. Brinz, MD & Angelo Russo, MD | Metairie | Louisiana | 70006 | — |
| Hematology and Oncology Specialists | New Orleans | Louisiana | 70115 | — |
| LSU Health Science Center | Shreveport | Louisiana | 71103 | — |
| LSU Health Scine Center | Shreveport | Louisiana | 71130 | — |
| St. Agnes Hospital | Baltimore | Maryland | 21229 | — |
| Great Lakes Cancer Institute | Lansing | Michigan | 48910 | — |
| U of Minnesota | Minneapolis | Minnesota | 55455 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| San Juan Oncology Associates | Farmington | New Mexico | 87401 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Cancer Center of the Carolinas | Greenville | North Carolina | 29615 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| University Hospitals of Cleveland, Case Comprehensive Cancer Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Kaiser Permanente Northwest Region Oncology/Hemacology | Portland | Oregon | 97227 | — |
| Kaiser Permanente Northwest Region | Portland | Oregon | 97227 | — |
| Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | 15224 | — |
| University of Pittsburg, Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| MUSC Hollings Cancer Center | Charleston | South Carolina | 29425 | — |
| Cancer Center of the Carolinas | Greenville | South Carolina | 29615 | — |
| Cancer Centers of the Carolinas | Greenville | South Carolina | 29615 | — |
| The Jones Clinic | Germantown | Tennessee | 38138 | — |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| UT Southwestern Harold C. Simmons Comprehensive Cancer Center | Dallas | Texas | 75390 | — |
| University of Texas / MD Anderson Cancer Center | Houston | Texas | 77030-4009 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| University of Virgina Cancer Center, UVA Division of Hematology & Oncology | Charlottesville | Virginia | 22908 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 25 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00124748, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 3, 2012 · Synced Sep 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00124748 live on ClinicalTrials.gov.