WATCHMAN Left Atrial Appendage System for Embolic PROTECTion in Patients With Atrial Fibrillation
Public ClinicalTrials.gov record NCT00129545. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
WATCHMAN Left Atrial Appendage System for Embolic PROTECTion in Patients With Atrial Fibrillation (PROTECT AF)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multi-center, prospective, randomized study, stratified by center, comparing the WATCHMAN device to long term warfarin therapy, demonstrating that the treatment arm is non-inferior to the control arm. This study was amended to allow for a non-randomized arm and increased enrollment.
Study identification
- NCT ID
- NCT00129545
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 800 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 2005 (Type not available)
- Primary completion
- Aug 2013 (Actual)
- Completion
- May 2014 (Actual)
- Last update posted
- May 15, 2015
2005 – 2014
United States locations
- U.S. sites
- 58
- U.S. states
- 25
- U.S. cities
- 49
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Advanced Cardiac Specialists | Gilbert | Arizona | 85233 | — |
| Arizona Arrhythmia | Scottsdale | Arizona | 85251 | — |
| Foundation for Cardiovascular Medicine | La Jolla | California | 92037 | — |
| Los Angeles Cardiology Associates | Los Angeles | California | 90017 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| El Camino Hospital | Mountain View | California | 94040 | — |
| Orange County Heart | Orange County | California | 92868 | — |
| UC Davis Medical Center | Sacramento | California | 95817 | — |
| St. John's Hospital / Pacific Heart | Santa Monica | California | 90404 | — |
| Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Baptist Cardiac and Vascular Institute | Miami | Florida | 33176 | — |
| Bay Heart Group | Tampa | Florida | 33607 | — |
| Emory University Midtown Hospital | Atlanta | Georgia | 30308 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| North Shore University | Evanston | Illinois | 60201 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Prairie Education Research Cooperative | Springfield | Illinois | 60637 | — |
| Baptist Hospital West | Lexington | Kentucky | 40503 | — |
| University of Kentucky | Lexington | Kentucky | 40536-0294 | — |
| Terrebonne General Medical Center | Houma | Louisiana | 70360 | — |
| Ochsner Clinic | New Orleans | Louisiana | 70121 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| University of Michigan Medical Center | Ann Arbor | Michigan | 48109 | — |
| William Beaumont | Royal Oak | Michigan | 48073 | — |
| Abbott Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Mayo Clinic | Rochester | Minnesota | 55902 | — |
| St. Paul Heart Clinic | Saint Paul | Minnesota | 55102 | — |
| University of Mississippi Healthcare Center | Jackson | Mississippi | 39216 | — |
| St. Luke's Hospital | Kansas City | Missouri | 64111 | — |
| Nebraska Heart Institute | Lincoln | Nebraska | 68526 | — |
| Cooper University Hospital | Camden | New Jersey | 08103 | — |
| New Mexico Heart Institute | Albuquerque | New Mexico | 87102 | — |
| New York University Medical Center | New York | New York | 10016 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Mt. Sinai Medical Center | New York | New York | — | — |
| Summa Health System | Akron | Ohio | 44304 | — |
| Lindner Clinical Trial Center | Cincinnati | Ohio | 45219 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Harrisburg Hospital / Associated Cardiology | Harrisburg | Pennsylvania | 17110 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Presbyterian University Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| Moffitt Heart & Vascular | Wormleysburg | Pennsylvania | 17043 | — |
| Mercy Medical Center West | Knoxville | Tennessee | 37934 | — |
| St. Thomas Research Institute | Nashville | Tennessee | — | — |
| Texas Cardiac Arrhythmia | Austin | Texas | 78705 | — |
| St. Lukes Episcopal Hospital | Houston | Texas | 77030 | — |
| Intermountain Medical Center | Salt Lake City | Utah | 84107 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| Inova Fairfax Hospital | Falls Church | Virginia | 22042 | — |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| Swedish Medical Center | Seattle | Washington | 98104 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00129545, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 15, 2015 · Synced Oct 27, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00129545 live on ClinicalTrials.gov.