A Study to Evaluate Fixed Dose Carbidopa/Levodopa/Entacapone Versus Immediate Release Carbidopa/Levodopa
Public ClinicalTrials.gov record NCT00134966. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 39 Week Randomized, Double-Blind, Parallel Group, Multicenter Study to Evaluate the Effect of Fixed Dose Carbidopa/Levodopa/Entacapone 100 mg t.i.d. vs. Immediate Release Carbidopa/Levodopa 25/100 mg (t.i.d.) in Parkinson's Disease Patients Requiring Levodopa
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to achieve approval for the use of carbidopa/levodopa/entacapone in early Parkinson's disease (PD) by demonstrating that when used as initial levodopa therapy in early PD, carbidopa/levodopa/entacapone provides significantly greater symptomatic benefit than immediate release carbidopa/levodopa administered at the same levodopa dosage level of 100 mg three times a day (t.i.d.).
Study identification
- NCT ID
- NCT00134966
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 493 participants
Conditions and interventions
Conditions
Interventions
Drug
Eligibility (public fields only)
- Age range
- 30 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 31, 2005
- Primary completion
- Aug 31, 2007
- Completion
- Aug 31, 2007
- Last update posted
- May 16, 2017
2005 – 2007
United States locations
- U.S. sites
- 17
- U.S. states
- 11
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barrow Neurology Clinics at St. Joseph's Hosptial & Medical Center | Phoenix | Arizona | 85013 | — |
| Coastal Neurological Medical Group, Inc | La Jolla | California | 92037 | — |
| Neurosearch, Inc. | Reseda | California | 91335 | — |
| University of Florida Health Science Center | Jacksonville | Florida | 32209 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| USF Medical Clinic | Tampa | Florida | 33612 | — |
| Springfield Neurology Associates, LLC | Springfield | Massachusetts | 01104 | — |
| Clinical Neuroscience Center | Southfield | Michigan | 48034 | — |
| Melbourne Internal Medicine Associates | Westlake | Ohio | 44145 | — |
| Westmoreland Neurology Associates, Inc. | Greensburg | Pennsylvania | 15601 | — |
| Lankenau Hospital | Wynnewood | Pennsylvania | 19096-3425 | — |
| NeuroHealth | Warwick | Rhode Island | 02886 | — |
| Coastal Neurology, PA | Beaufort | South Carolina | 29902 | — |
| Senior Adults Specialty Research | Austin | Texas | 78757 | — |
| Baylor College of Medicine, Parkinson's Disease Center | Houston | Texas | 77030 | — |
| Neurology Associates | San Marcos | Texas | 78666 | — |
| Blue Ridge Research Center at Roanoke Neurological Center | Roanoke | Virginia | 24014 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 43 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00134966, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 16, 2017 · Synced Sep 1, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00134966 live on ClinicalTrials.gov.