A United States Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression
Public ClinicalTrials.gov record NCT00208156. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label Extension Study of the Safety and Tolerability of CORLUX™ (Mifepristone) for Recurrent Psychotic Symptoms in Patients With Major Depressive Disorder With Psychotic Features
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. Under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress, triggering a healthy stress response. People who suffer from psychotic major depression may have unusually high levels of cortisol circulating within them or abnormal patterns of cortisol levels, overloading the stress response mechanism and causing symptoms of psychosis such as delusional thoughts or hallucinations. If Corlux can keep the body's cortisol receptors from being overloaded, the stress response system may return to normal function, which may result in improvement of symptoms. The purpose of this study is to allow patients who have already participated in an earlier 8 week study of Corlux versus placebo (an inactive pill) to receive additional courses of treatment with Corlux periodically if a psychotic episode should reappear during a period of one year.
Study identification
- NCT ID
- NCT00208156
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 87 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 30, 2005
- Primary completion
- Oct 31, 2006
- Completion
- Oct 31, 2006
- Last update posted
- Feb 14, 2012
2005 – 2006
United States locations
- U.S. sites
- 13
- U.S. states
- 10
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cnri, Llc | San Diego | California | 92126 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30308 | — |
| Robert Horne M.D. | Las Vegas | Nevada | 89102 | — |
| CNS Research Institute (CRI) | Clementon | New Jersey | 08021 | — |
| New Jersey Medical School - UMDNJ | Newark | New Jersey | 07101 | — |
| BioBehavioral Health | Toms River | New Jersey | 08755 | — |
| Zucker Hillside Hospital | Glen Oaks | New York | 11004 | — |
| Neurobehavioral Research, Inc. | Lawrence | New York | 11559 | — |
| IPS Research Company | Oklahoma City | Oklahoma | 73101 | — |
| CNS Research Institute (CRI) | Philadelphia | Pennsylvania | 19149 | — |
| Claghorn-Lesem Research Clinic | Bellaire | Texas | 77401 | — |
| International Clinical Research Associates | Richmond | Virginia | 23229 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98004 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00208156, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 14, 2012 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00208156 live on ClinicalTrials.gov.