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Completed Phase 3 Interventional

TROPHY - Candesartan Cilexetil Long-term Hypertension Prevention Trial

ClinicalTrials.gov ID: NCT00227318

Public ClinicalTrials.gov record NCT00227318. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 28, 2026, 10:28 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Double-blind, Placebo-controlled, Multicenter, Long-term Trial of Preventing Hypertension Using Candesartan Cilexetil 16 mg in Patients With High Normal Blood Pressure (TROPHY)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to determine the effectiveness of candesartan cilexetil in preventing hypertension in people with high normal blood pressure. Patients will be randomized to either Candesartan or placebo for an initial 2-year period followed by a second 2-year period of placebo for all patients.

Study identification

NCT ID
NCT00227318
Recruitment status
Completed
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
1,000 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range
30 Years to 65 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 1998 (Type not available)
Primary completion
Oct 2005 (Actual)
Completion
Oct 2005 (Actual)
Last update posted
Aug 30, 2011

1998 – 2005

United States locations

U.S. sites
42
U.S. states
24
U.S. cities
42
Facility City State ZIP Site status
Research Site Mobile Alabama — —
Research Site Long Beach California — —
Research Site Redondo Beach California — —
Research Site Santa Ana California — —
Research Site Tustin California — —
Research Site Wilmington Delaware — —
Research Site Washington D.C. District of Columbia — —
Research Site Bay Pines Florida — —
Research Site Gainsville Florida — —
Research Site Ocala Florida — —
Research Site Chicago Illinois — —
Research Site Shawnee Mission Kansas — —
Research Site Chelsea Michigan — —
Research Site Detroit Michigan — —
Research Site Minneapolis Minnesota — —
Research Site Jackson Mississippi — —
Research Site Florissant Missouri — —
Research Site Kansas City Missouri — —
Research Site St Louis Missouri — —
Research Site Buffalo New York — —
Research Site Rochester New York — —
Research Site Williamsville New York — —
Research Site Asheville North Carolina — —
Research Site Chapel Hill North Carolina — —
Research Site Winston-Salem North Carolina — —
Research Site Fargo North Dakota — —
Research Site Canton Ohio — —
Research Site Cleveland Ohio — —
Research Site Columbus Ohio — —
Research Site Oklahoma City Oklahoma — —
Research Site Allentown Pennsylvania — —
Research Site Fleetwood Pennsylvania — —
Research Site Pittsburgh Pennsylvania — —
Research Site Providence Rhode Island — —
Research Site Warwick Rhode Island — —
Research Site Charleston South Carolina — —
Research Site Memphis Tennessee — —
Research Site Dallas Texas — —
Research Site Houston Texas — —
Research Site Richmond Virginia — —
Research Site Morgantown West Virginia — —
Research Site Milwaukee Wisconsin — —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT00227318, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 30, 2011 · Synced Oct 28, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT00227318 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →