Lofexidine for Inpatient Opiate Detox
Public ClinicalTrials.gov record NCT00235729. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
CSP #1024 - A Phase III, Randomized, Multi-Center, Double Blind, Placebo-Controlled Study of Safety and Efficacy of Lofexidine for Relief of Symptoms in Subjects Undergoing Inpatient Opiate Detoxification.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main objective of this study is to investigate the effectiveness of lofexidine in reducing withdrawal symptoms among subjects undergoing opiate detoxification. Currently, lofexidine is the most commonly used non-opiate medication for detoxification from opiates in the United Kingdom (UK). There is no non-opiate medication approved by the Food and Drug Administration (FDA) for the same indication in the United States (US). The only medications currently approved by the FDA for opiate detoxification are methadone and buprenorphine. These medications, however, have the potential to be abused. Lofexidine, on the other hand, offers a unique advantage for opiate detoxification because it is not addicting, is easy to use, and has a favorable safety profile.
Study identification
- NCT ID
- NCT00235729
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 264 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2006 (Type not available)
- Primary completion
- Oct 2007 (Actual)
- Completion
- Oct 2007 (Actual)
- Last update posted
- Mar 20, 2009
2006 – 2007
United States locations
- U.S. sites
- 16
- U.S. states
- 15
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| CNS, Cerritos | Cerritos | California | 90703 | — |
| CNS Psychiatric Institute of Washington | Washington D.C. | District of Columbia | 20016 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30308 | — |
| Alexian Center for Psychiatric Research | Hoffman Estates | Illinois | 60194 | — |
| University of Kentucky | Lexington | Kentucky | 40502 | — |
| VA Maryland Health Care System, Baltimore | Baltimore | Maryland | 21201 | — |
| Wayne State University School of Medicine | Detroit | Michigan | 48207 | — |
| Richmond Medical Center | Staten Island | New York | 10304 | — |
| VA Medical Center, Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| VA Medical Center, Providence | Providence | Rhode Island | 02908 | — |
| Psychiatric Hospital at Vanderbilt | Nashville | Tennessee | 37232-8650 | — |
| Research Across America | Dallas | Texas | 75234 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229-3900 | — |
| VA Salt Lake City Health Care System, Salt Lake City | Salt Lake City | Utah | 84148 | — |
| VA Puget Sound Health Care System, Seattle | Seattle | Washington | 98108 | — |
| Aurora Psychiatric Hospital | Wauwatosa | Wisconsin | 53213 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00235729, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 20, 2009 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00235729 live on ClinicalTrials.gov.