ClinicalTrials.gov record
Long-Term Safety Evaluation Of Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain
ClinicalTrials.gov ID: NCT00241722
Public ClinicalTrials.gov record NCT00241722. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate Long-Term Safety and Efficacy of Alvimopan 0.5mg Twice Daily for 12 Months for the Treatment of Opioid-Induced Bowel Dysfunction in Adults Taking Opioid Therapy for Persistent Non-Cancer Pain
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Adults who are taking opioid therapy for persistent non-cancer pain and have resulting opioid-induced bowel dysfunction (OBD) will be randomized (1:1) to alvimopan or placebo. The primary objective of this Phase 3 long-term safety study is to compare alvimopan with placebo for safety and tolerability in the treatment of OBD. Participants will be required to attend 8 clinic visits over approximately 1 year.
Study identification
- NCT ID
- NCT00241722
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
- Industry
- Enrollment
- 805 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 1, 2005 (Actual)
- Primary completion
- Feb 1, 2007 (Actual)
- Completion
- Feb 1, 2007 (Actual)
- Last update posted
- Aug 30, 2017
2005 – 2007
United States locations
- U.S. sites
- 143
- U.S. states
- 37
- U.S. cities
- 123
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| GSK Investigational Site | Birmingham | Alabama | 35215 | — |
| GSK Investigational Site | Birmingham | Alabama | 35242 | — |
| GSK Investigational Site | Birmingham | Alabama | 35244 | — |
| GSK Investigational Site | Huntsville | Alabama | 35801 | — |
| GSK Investigational Site | Mobile | Alabama | 36606 | — |
| GSK Investigational Site | Muscle Shoals | Alabama | 35662 | — |
| GSK Investigational Site | Northport | Alabama | 35476 | — |
| GSK Investigational Site | Glendale | Arizona | 85306 | — |
| GSK Investigational Site | Phoenix | Arizona | 85023 | — |
| GSK Investigational Site | Phoenix | Arizona | 85029 | — |
| GSK Investigational Site | Phoenix | Arizona | 85032 | — |
| GSK Investigational Site | Scottsdale | Arizona | 85251 | — |
| GSK Investigational Site | Scottsdale | Arizona | 85258 | — |
| GSK Investigational Site | Sun City | Arizona | 85351 | — |
| GSK Investigational Site | Tempe | Arizona | 85282 | — |
| GSK Investigational Site | Tucson | Arizona | 85712 | — |
| GSK Investigational Site | Tucson | Arizona | 85741 | — |
| GSK Investigational Site | Hot Springs | Arkansas | 71913 | — |
| GSK Investigational Site | Little Rock | Arkansas | 72223 | — |
| GSK Investigational Site | Anaheim | California | 92801 | — |
| GSK Investigational Site | Anaheim | California | 92805 | — |
| GSK Investigational Site | Bakersfield | California | 93311 | — |
| GSK Investigational Site | Beverly Hills | California | 90211 | — |
| GSK Investigational Site | Buena Park | California | 90620 | — |
| GSK Investigational Site | Burbank | California | 91505 | — |
| GSK Investigational Site | Los Gatos | California | 95032 | — |
| GSK Investigational Site | Orange | California | 92868 | — |
| GSK Investigational Site | Palm Springs | California | 92262 | — |
| GSK Investigational Site | Pismo Beach | California | 93449 | — |
| GSK Investigational Site | San Diego | California | 92108 | — |
| GSK Investigational Site | San Diego | California | 92120 | — |
| GSK Investigational Site | San Diego | California | 92121 | — |
| GSK Investigational Site | Torrance | California | 90503 | — |
| GSK Investigational Site | Vista | California | 92083 | — |
| GSK Investigational Site | Stratford | Connecticut | 6497 | — |
| GSK Investigational Site | Trumbull | Connecticut | 06611 | — |
| GSK Investigational Site | Brandon | Florida | 33511 | — |
| GSK Investigational Site | Chiefland | Florida | 32626 | — |
| GSK Investigational Site | Clearwater | Florida | 33756 | — |
| GSK Investigational Site | Clearwater | Florida | 33765 | — |
| GSK Investigational Site | Deerfield Beach | Florida | 33441 | — |
| GSK Investigational Site | DeLand | Florida | 32720 | — |
| GSK Investigational Site | Fort Myers | Florida | 33907 | — |
| GSK Investigational Site | Gainesville | Florida | 32607 | — |
| GSK Investigational Site | Holly Hill | Florida | 32117 | — |
| GSK Investigational Site | Hollywood | Florida | 33021 | — |
| GSK Investigational Site | Jupiter | Florida | 33458 | — |
| GSK Investigational Site | Miami | Florida | 33169 | — |
| GSK Investigational Site | Ocala | Florida | 32607 | — |
| GSK Investigational Site | Ocala | Florida | 34471 | — |
| GSK Investigational Site | Orlando | Florida | 32804 | — |
| GSK Investigational Site | Ormond Beach | Florida | 32174 | — |
| GSK Investigational Site | Saint Cloud | Florida | 34769 | — |
| GSK Investigational Site | West Palm Beach | Florida | 33409 | — |
| GSK Investigational Site | Dawsonville | Georgia | 30534 | — |
| GSK Investigational Site | Marietta | Georgia | 30066 | — |
| GSK Investigational Site | Stockbridge | Georgia | 30281 | — |
| GSK Investigational Site | Suwanee | Georgia | 30024 | — |
| GSK Investigational Site | Boise | Idaho | 83702 | — |
| GSK Investigational Site | Meridian | Idaho | 83642 | — |
| GSK Investigational Site | Arlington Heights | Illinois | 60005 | — |
| GSK Investigational Site | Bloomington | Illinois | 61701 | — |
| GSK Investigational Site | Chicago | Illinois | 60610 | — |
| GSK Investigational Site | Rockford | Illinois | 61107 | — |
| GSK Investigational Site | Elkhart | Indiana | 46515 | — |
| GSK Investigational Site | Indianapolis | Indiana | 46250 | — |
| GSK Investigational Site | Louisville | Kentucky | 40205 | — |
| GSK Investigational Site | Louisville | Kentucky | 40213 | — |
| GSK Investigational Site | Madisonville | Kentucky | 42431 | — |
| GSK Investigational Site | Baton Rouge | Louisiana | 70808 | — |
| GSK Investigational Site | Shreveport | Louisiana | 71103 | — |
| GSK Investigational Site | Pasadena | Maryland | 21122 | — |
| GSK Investigational Site | Rockville | Maryland | 20852 | — |
| GSK Investigational Site | Boston | Massachusetts | 02115 | — |
| GSK Investigational Site | Brockton | Massachusetts | 02301 | — |
| GSK Investigational Site | Wellesley Hills | Massachusetts | 02481 | — |
| GSK Investigational Site | Detroit | Michigan | 48202 | — |
| GSK Investigational Site | Grand Blanc | Michigan | 48439 | — |
| GSK Investigational Site | Portage | Michigan | 49024 | — |
| GSK Investigational Site | Traverse City | Michigan | 49684 | — |
| GSK Investigational Site | Chaska | Minnesota | 55318 | — |
| GSK Investigational Site | Olive Branch | Mississippi | 38654 | — |
| GSK Investigational Site | Manchester | Missouri | 63021 | — |
| GSK Investigational Site | Nixa | Missouri | 65714 | — |
| GSK Investigational Site | St Louis | Missouri | 63108 | — |
| GSK Investigational Site | Missoula | Montana | 59804 | — |
| GSK Investigational Site | Omaha | Nebraska | 68114 | — |
| GSK Investigational Site | Henderson | Nevada | 89015 | — |
| GSK Investigational Site | Las Vegas | Nevada | 89102 | — |
| GSK Investigational Site | Las Vegas | Nevada | 89103 | — |
| GSK Investigational Site | Las Vegas | Nevada | 89119 | — |
| GSK Investigational Site | Dover | New Hampshire | 03820 | — |
| GSK Investigational Site | Blackwood | New Jersey | 08012 | — |
| GSK Investigational Site | Elizabeth | New Jersey | 07202 | — |
| GSK Investigational Site | Albuquerque | New Mexico | 87102 | — |
| GSK Investigational Site | Lake Success | New York | 11042 | — |
| GSK Investigational Site | Asheville | North Carolina | 28801 | — |
| GSK Investigational Site | Charlotte | North Carolina | 28204 | — |
| GSK Investigational Site | Concord | North Carolina | 28025 | — |
| GSK Investigational Site | Greensboro | North Carolina | 27401 | — |
| GSK Investigational Site | Greensboro | North Carolina | 27403 | — |
| GSK Investigational Site | Hickory | North Carolina | 28601 | — |
| GSK Investigational Site | Raleigh | North Carolina | 27607 | — |
| GSK Investigational Site | Winston-Salem | North Carolina | 27103 | — |
| GSK Investigational Site | Centerville | Ohio | 45450 | — |
| GSK Investigational Site | Cincinnati | Ohio | 45219 | — |
| GSK Investigational Site | Cincinnati | Ohio | 45224 | — |
| GSK Investigational Site | Columbus | Ohio | 43215 | — |
| GSK Investigational Site | Dayton | Ohio | 45408 | — |
| GSK Investigational Site | Dayton | Ohio | 45439 | — |
| GSK Investigational Site | Dayton | Ohio | 46432 | — |
| GSK Investigational Site | Clinton | Oklahoma | 73601 | — |
| GSK Investigational Site | Oklahoma City | Oklahoma | 73112 | — |
| GSK Investigational Site | Medford | Oregon | 97504 | — |
| GSK Investigational Site | Oregon City | Oregon | 97045 | — |
| GSK Investigational Site | Portland | Oregon | 97210 | — |
| GSK Investigational Site | Carnegie | Pennsylvania | 15106 | — |
| GSK Investigational Site | Pittsburgh | Pennsylvania | 15243 | — |
| GSK Investigational Site | Reading | Pennsylvania | 19611 | — |
| GSK Investigational Site | Woonsocket | Rhode Island | 02895 | — |
| GSK Investigational Site | Chattanooga | Tennessee | 37403 | — |
| GSK Investigational Site | Clarksville | Tennessee | 37043 | — |
| GSK Investigational Site | Kingsport | Tennessee | 37660 | — |
| GSK Investigational Site | Arlington | Texas | 76017 | — |
| GSK Investigational Site | Brownwood | Texas | 76801 | — |
| GSK Investigational Site | Dallas | Texas | 75218 | — |
| GSK Investigational Site | Grand Prairie | Texas | 75052 | — |
| GSK Investigational Site | Houston | Texas | 77074 | — |
| GSK Investigational Site | Houston | Texas | 77090 | — |
| GSK Investigational Site | Lake Jackson | Texas | 77566 | — |
| GSK Investigational Site | Lancaster | Texas | 75146 | — |
| GSK Investigational Site | Richardson | Texas | 75080 | — |
| GSK Investigational Site | San Antonio | Texas | 78238 | — |
| GSK Investigational Site | Salt Lake City | Utah | 84106 | — |
| GSK Investigational Site | Salt Lake City | Utah | 84120 | — |
| GSK Investigational Site | Norfolk | Virginia | 23502 | — |
| GSK Investigational Site | Richmond | Virginia | 23294 | — |
| GSK Investigational Site | Virginia Beach | Virginia | 23452 | — |
| GSK Investigational Site | Bellingham | Washington | 98226 | — |
| GSK Investigational Site | Edmonds | Washington | 98026 | — |
| GSK Investigational Site | Spokane | Washington | 99204 | — |
| GSK Investigational Site | Tacoma | Washington | 98405 | — |
| GSK Investigational Site | Charleston | West Virginia | 25304 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 84 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00241722, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 30, 2017 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00241722 live on ClinicalTrials.gov.