TMC114-C226: An Early Access Program to Evaluate the Long-term Safety and Tolerability of TMC114 Combined With a Low Dose of Ritonavir (TMC114/r) With Other Antiretrovirals, for HIV-1 Infected Patients Who Have Failed Multiple Antiretroviral Regimens.

ClinicalTrials.gov ID: NCT00245739

Public ClinicalTrials.gov record NCT00245739. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 3, 2026, 1:01 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Early Access of TMC114 in Combination With Low-dose Ritonavir (TMC/r)) and Other Antiretrovirals (ARVs) in Highly Treatment Experienced HIV-1 Infected Patients With Limited to no Treatment Options.

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to provide early access to TMC114 (a protease inhibitor) for HIV-1 infected patients with limited or no treatment options, who have failed multiple antiretroviral (ARV) regimens, and to evaluate the longer-term safety and tolerability of TMC114/r in combination with other antiretrovirals

Study identification

NCT ID: NCT00245739
Recruitment status: Approved For Marketing
Study type: Expanded access
Phase: Not listed
Lead sponsor: Tibotec Pharmaceuticals, Ireland; Industry
Enrollment: Not listed

Conditions and interventions

Conditions

HIV Infections

Interventions

TMC-114 Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Not listed
Primary completion: Not listed
Completion: Not listed
Last update posted: Apr 10, 2014

United States locations

U.S. sites: 202
U.S. states: 38
U.S. cities: 202

Facility	City	State	ZIP	Site status
Not listed	Anniston	Alabama	—	—
Not listed	Birmingham	Alabama	—	—
Not listed	Mesa	Arizona	—	—
Not listed	Phoenix	Arizona	—	—
Not listed	Tucson	Arizona	—	—
Not listed	Anaheim	California	—	—
Not listed	Bakersfield	California	—	—
Not listed	Baldwin Park	California	—	—
Not listed	Beverly Hills	California	—	—
Not listed	Carmichael	California	—	—
Not listed	Fontana	California	—	—
Not listed	Fountain Valley	California	—	—
Not listed	French Camp	California	—	—
Not listed	Glendale	California	—	—
Not listed	Harbor City	California	—	—
Not listed	Hayward	California	—	—
Not listed	Loma Linda	California	—	—
Not listed	Long Beach	California	—	—
Not listed	Los Angeles	California	—	—
Not listed	Los Angles	California	—	—
Not listed	Newport Beach	California	—	—
Not listed	Oakland	California	—	—
Not listed	Palm Springs	California	—	—
Not listed	Palo Alto	California	—	—
Not listed	Panorama City	California	—	—
Not listed	Paramount	California	—	—
Not listed	Richmond	California	—	—
Not listed	Salinas	California	—	—
Not listed	San Diego	California	—	—
Not listed	San Diego, La Jolla	California	—	—
Not listed	San Francisco	California	—	—
Not listed	San Mateo	California	—	—
Not listed	San Rafael	California	—	—
Not listed	Santa Ana	California	—	—
Not listed	Santa Clara	California	—	—
Not listed	Santa Clarita	California	—	—
Not listed	Santa Rosa	California	—	—
Not listed	Stanford	California	—	—
Not listed	Sunnyvale	California	—	—
Not listed	Tarzana	California	—	—
Not listed	Ukiah	California	—	—
Not listed	West Hollywood	California	—	—
Not listed	Woodland Hills	California	—	—
Not listed	Denver	Colorado	—	—
Not listed	Glastonbury	Connecticut	—	—
Not listed	Hartford	Connecticut	—	—
Not listed	New Haven	Connecticut	—	—
Not listed	Norwalk	Connecticut	—	—
Not listed	Norwich	Connecticut	—	—
Not listed	Stanford	Connecticut	—	—
Not listed	Vernon Rockville	Connecticut	—	—
Not listed	Washington D.C.	District of Columbia	—	—
Not listed	Boynton Beach	Florida	—	—
Not listed	Brandon	Florida	—	—
Not listed	Fort Lauderdale	Florida	—	—
Not listed	Fort Laudersale	Florida	—	—
Not listed	Fort Myers	Florida	—	—
Not listed	Hollywood	Florida	—	—
Not listed	Jacksonville	Florida	—	—
Not listed	LaBelle	Florida	—	—
Not listed	Melbourne	Florida	—	—
Not listed	Miami	Florida	—	—
Not listed	Miami Beach	Florida	—	—
Not listed	North Miami Beach	Florida	—	—
Not listed	North Palm Beach	Florida	—	—
Not listed	Orlando	Florida	—	—
Not listed	Plantation	Florida	—	—
Not listed	Port Saint Lucie	Florida	—	—
Not listed	Safety Harbor	Florida	—	—
Not listed	Sarasota	Florida	—	—
Not listed	Tampa	Florida	—	—
Not listed	Vero Beach	Florida	—	—
Not listed	West Palm Beach	Florida	—	—
Not listed	Winter Park	Florida	—	—
Not listed	Atlanta	Georgia	—	—
Not listed	Augusta	Georgia	—	—
Not listed	Austell	Georgia	—	—
Not listed	Decatur	Georgia	—	—
Not listed	Jesup	Georgia	—	—
Not listed	Macon	Georgia	—	—
Not listed	Marietta	Georgia	—	—
Not listed	Riverdale	Georgia	—	—
Not listed	Tucker	Georgia	—	—
Not listed	Honolulu	Hawaii	—	—
Not listed	Kahului	Hawaii	—	—
Not listed	Kapaa	Hawaii	—	—
Not listed	Boise	Idaho	—	—
Not listed	Chicago	Illinois	—	—
Not listed	Decatur	Illinois	—	—
Not listed	Granite City	Illinois	—	—
Not listed	Joliet	Illinois	—	—
Not listed	Rockford	Illinois	—	—
Not listed	Round Lake Beach	Illinois	—	—
Not listed	Springfield	Illinois	—	—
Not listed	Topeka	Kansas	—	—
Not listed	Henderson	Kentucky	—	—
Not listed	Paducah	Kentucky	—	—
Not listed	New Orleans	Louisiana	—	—
Not listed	Bangor	Maine	—	—
Not listed	Lewiston	Maine	—	—
Not listed	Monmouth	Maine	—	—
Not listed	Portland	Maine	—	—
Not listed	Baltimore	Maryland	—	—
Not listed	Bethesda	Maryland	—	—
Not listed	Elkton	Maryland	—	—
Not listed	Silver Spring	Maryland	—	—
Not listed	Boston	Massachusetts	—	—
Not listed	Cambridge	Massachusetts	—	—
Not listed	Springfield	Massachusetts	—	—
Not listed	Berkley	Michigan	—	—
Not listed	Detroit	Michigan	—	—
Not listed	Grosse Pointe Woods	Michigan	—	—
Not listed	Marquette	Michigan	—	—
Not listed	Minneapolis	Minnesota	—	—
Not listed	Greenwood	Mississippi	—	—
Not listed	Columbia	Missouri	—	—
Not listed	Kansas City	Missouri	—	—
Not listed	St Louis	Missouri	—	—
Not listed	Las Vegas	Nevada	—	—
Not listed	Lebanon	New Hampshire	—	—
Not listed	East Orange	New Jersey	—	—
Not listed	Galloway	New Jersey	—	—
Not listed	Hackensack	New Jersey	—	—
Not listed	Hamilton	New Jersey	—	—
Not listed	Hoboken	New Jersey	—	—
Not listed	Jersey City	New Jersey	—	—
Not listed	Long Branch	New Jersey	—	—
Not listed	Maplewood	New Jersey	—	—
Not listed	Neptune City	New Jersey	—	—
Not listed	Newark	New Jersey	—	—
Not listed	Perth Amboy	New Jersey	—	—
Not listed	Somers Point	New Jersey	—	—
Not listed	Voorhees Township	New Jersey	—	—
Not listed	West Orange	New Jersey	—	—
Not listed	Westfield	New Jersey	—	—
Not listed	Albuquerque	New Mexico	—	—
Not listed	Albany	New York	—	—
Not listed	Briarcliff	New York	—	—
Not listed	Bronxville	New York	—	—
Not listed	Brooklyn	New York	—	—
Not listed	Flushing	New York	—	—
Not listed	Harris	New York	—	—
Not listed	Manhasset	New York	—	—
Not listed	Mount Vernon	New York	—	—
Not listed	New York	New York	—	—
Not listed	Rochester	New York	—	—
Not listed	Syracuse	New York	—	—
Not listed	The Bronx	New York	—	—
Not listed	Valhalla	New York	—	—
Not listed	Yonkers	New York	—	—
Not listed	Asheville	North Carolina	—	—
Not listed	Chapel Hill	North Carolina	—	—
Not listed	Greensboro	North Carolina	—	—
Not listed	Greenville	North Carolina	—	—
Not listed	Huntersville	North Carolina	—	—
Not listed	Wilmington	North Carolina	—	—
Not listed	Winston-Salem	North Carolina	—	—
Not listed	Akron	Ohio	—	—
Not listed	Cincinnati	Ohio	—	—
Not listed	Cleveland	Ohio	—	—
Not listed	Columbus	Ohio	—	—
Not listed	Dayton	Ohio	—	—
Not listed	Oklahoma City	Oklahoma	—	—
Not listed	Portland	Oregon	—	—
Not listed	Allentown	Pennsylvania	—	—
Not listed	Easton	Pennsylvania	—	—
Not listed	Hershey	Pennsylvania	—	—
Not listed	Philadelphia	Pennsylvania	—	—
Not listed	Pittsburgh	Pennsylvania	—	—
Not listed	West Reading	Pennsylvania	—	—
Not listed	Providence	Rhode Island	—	—
Not listed	Charleston	South Carolina	—	—
Not listed	Columbia	South Carolina	—	—
Not listed	West Columbia	South Carolina	—	—
Not listed	Hermitage	Tennessee	—	—
Not listed	Johnson City	Tennessee	—	—
Not listed	Knoxville	Tennessee	—	—
Not listed	Memphis	Tennessee	—	—
Not listed	Nashville	Tennessee	—	—
Not listed	Austin	Texas	—	—
Not listed	Bryan	Texas	—	—
Not listed	Dallas	Texas	—	—
Not listed	El Paso	Texas	—	—
Not listed	Fort Worth	Texas	—	—
Not listed	Galveston	Texas	—	—
Not listed	Harlingen	Texas	—	—
Not listed	Houston	Texas	—	—
Not listed	Lackland City	Texas	—	—
Not listed	Longview	Texas	—	—
Not listed	San Antonio	Texas	—	—
Not listed	Annandale	Virginia	—	—
Not listed	Charlottesville	Virginia	—	—
Not listed	Fairfax	Virginia	—	—
Not listed	Hampton	Virginia	—	—
Not listed	Newport News	Virginia	—	—
Not listed	Norfolk	Virginia	—	—
Not listed	Portsmouth	Virginia	—	—
Not listed	Richmond	Virginia	—	—
Not listed	Seattle	Washington	—	—
Not listed	Eau Claire	Wisconsin	—	—
Not listed	Madison	Wisconsin	—	—
Not listed	Milwaukee	Wisconsin	—	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 192 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT00245739, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 10, 2014 · Synced Sep 3, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT00245739 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →