Study to Assess the Efficacy and Safety of Rifaximin Administered BID in the Treatment of Patients With Diarrhea-Associated Irritable Bowel Syndrome
Public ClinicalTrials.gov record NCT00269412. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess The Efficacy and Safety of Three Different Doses (275, 550 AND 1100 MG) of Rifaximin Administered BID For Either Two or Four Weeks in The Treatment of Patients With Diarrhea-Associated Irritable Bowel Syndrome
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is placebo-controlled study of three rifaximin doses in patients with DIBS. Subjects will be randomized to receive daily doses of placebo BID, rifaximin 275 mg BID, rifaximin 550 mg BID, or 1100 mg BID for 14 days. These four groups will subsequently receive an additional two weeks of placebo for a total of 4 weeks of treatment. A fifth group of subjects will receive rifaximin 550 mg BID for a period of 28 days. Subjects who successfully respond to treatment at the end of the 28-day Treatment Phase will be followed in a Post-treatment Phase that includes study visits during Weeks 6, 8, 12 and 16. Subjects who relapse during the Post-treatment Phase will be discontinued from the study.
Study identification
- NCT ID
- NCT00269412
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 525 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2005 (Type not available)
- Primary completion
- Aug 2007 (Actual)
- Completion
- Sep 2008 (Actual)
- Last update posted
- Nov 25, 2019
2005 – 2008
United States locations
- U.S. sites
- 67
- U.S. states
- 26
- U.S. cities
- 64
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Scottsdale | Scottsdale | Arizona | 85259 | — |
| Premeire Pharmaceutical Research | Tempe | Arizona | 85282 | — |
| Advanced Clinical Research Institute | Anaheim | California | 92801 | — |
| Lovelace Scientific Resources | Irvine | California | 92618 | — |
| West Gastroenterology Medical Group | Los Angeles | California | 90045 | — |
| Beverly Hills Gastroenterology | Los Angeles | California | 90067 | — |
| Medical Associates Research Group | San Diego | California | 92123 | — |
| Gastroenterology Associates of Fairfield County | Bridgeport | Connecticut | 06606 | — |
| Connecticut Gastroenterology Institute | Bristol | Connecticut | 06010-0977 | — |
| Litchfield County Gastroenterology Associates, LLC | Torrington | Connecticut | 06790 | — |
| Clinical Research of West Florida | Clearwater | Florida | 33765 | — |
| University Clinical Research | DeLand | Florida | 32720 | — |
| Research Consultants Group | Hialeah | Florida | 33016 | — |
| Borland-Groover Clinic | Jacksonville | Florida | 32256 | — |
| Miami Research Associates | Miami | Florida | 33173 | — |
| Advanced Gastroenterology Associates | Palm Harbor | Florida | 34684 | — |
| Shafran Gastroenterology | Winter Park | Florida | 32789 | — |
| Florida Medical Clinic | Zephyrhills | Florida | 33542 | — |
| Rockford Gastroenterology | Rockford | Illinois | 61107 | — |
| Community Clinical Research Center | Anderson | Indiana | 46016 | — |
| Indianapolis Gastroenterology Research Foundation | Indianapolis | Indiana | 46237 | — |
| Gastrointestinal Clinic of Quad Citites | Davenport | Iowa | 52807 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160-7350 | — |
| Digestive Disorders Associates | Annapolis | Maryland | 21401 | — |
| Chevy Chase Clinical Research | Chevy Chase | Maryland | 20815 | — |
| Washington County Hospital | Hagerstown | Maryland | 21740 | — |
| Maryland Clinical Trials | Severna Park | Maryland | 21146 | — |
| Capital Gastroenterology Consultants, PA | Silver Springs | Maryland | 20901 | — |
| Coastal Research Associates | Braintree | Massachusetts | 02184 | — |
| Henry Ford Hospital | Chesterfield | Michigan | 48047 | — |
| Gastrointestinal Associates, PA | Jackson | Mississippi | 39202 | — |
| Digestive Health Specialists, PA | Tupelo | Mississippi | 38801 | — |
| Gastroenterology and Hepatology | Kansas City | Missouri | 64131 | — |
| Center for Digestive & Liver Diseases, Inc. | Mexico | Missouri | 65265 | — |
| Specialist in Gastroenterology | St Louis | Missouri | 63141 | — |
| Gastroenterology Specialities | Lincoln | Nebraska | 68503 | — |
| Long Island Clinical Research | Great Neck | New York | 11021 | — |
| New York Center for Clinical Research | Lake Success | New York | 11042 | — |
| Asheville Gastroenterology Associates | Asheville | North Carolina | 28801 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27579 | — |
| Charlotte Gastroenterology & Hepatology | Charlotte | North Carolina | 28207 | — |
| Vital re:Search | Greensboro | North Carolina | 27408 | — |
| Carolina Research | Greenville | North Carolina | 27834 | — |
| Bethany Medical Center | High Point | North Carolina | 27262 | — |
| East Carolina Gastroenterology | Jacksonville | North Carolina | 28546 | — |
| Wake Research Associates | Raleigh | North Carolina | 27612 | — |
| Not listed | Rocky Mount | North Carolina | 27804 | — |
| Hanover Medical Specialists, PA | Wilmington | North Carolina | 28401 | — |
| Consultants for Clinical Research | Cincinnati | Ohio | 45219 | — |
| Digestive Health Network | Cincinnati | Ohio | 45220 | — |
| GI & Liver Diseases Consultants | Dayton | Ohio | 45440 | — |
| Wells Institute for Health Awareness | Kettering | Ohio | 45429 | — |
| Oklahoma Foundation for Digestive Research | Oklahoma City | Oklahoma | 73104 | — |
| Digestive Health Specialists, PA | Oklahoma City | Oklahoma | 73112 | — |
| West Hills Gastroenterology Associates, PC | Portland | Oregon | 97225 | — |
| Columbia Gastroenterology Associates | Columbia | South Carolina | 29203 | — |
| ClinSearch | Chattanooga | Tennessee | 37404 | — |
| Regional Research Institute | Jackson | Tennessee | 38305 | — |
| Holston Valley Physicians | Kingsport | Tennessee | 37660 | — |
| Austin Gastroenterology | Austin | Texas | 78745 | — |
| Advanced Research Institute | Ogden | Utah | 84405 | — |
| University of Utah School of Medicine | Salt Lake City | Utah | 84132 | — |
| Internal Medicine Associates | Danville | Virginia | 24541 | — |
| Northwest Gastroenterology Associates | Bellevue | Washington | 98004 | — |
| North Pacific Clinical Research | Redmond | Washington | 98052 | — |
| Spokane Digestive Disease Center | Spokane | Washington | 99204 | — |
| Wisconsin Center for Advanced Research | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00269412, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 25, 2019 · Synced Oct 31, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00269412 live on ClinicalTrials.gov.