A Study to Evaluate the Effects of Rituximab on Immune Responses in Subjects With Active Rheumatoid Arthritis Receiving Background Methotrexate
Public ClinicalTrials.gov record NCT00282308. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II, Randomized, Parallel-group, Open-label, Multicenter Study to Evaluate the Effects of Rituximab on Immune Responses in Subjects With Active Rheumatoid Arthritis Receiving Background Methotrexate
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This was a Phase II, randomized, open-label, multicenter study designed to evaluate the immune response to vaccines after administration of 1000 mg of rituximab in subjects with active rheumatoid arthritis (RA) who were receiving background methotrexate (MTX).
Study identification
- NCT ID
- NCT00282308
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 103 participants
Conditions and interventions
Conditions
Interventions
- Rituximab Drug
- Methotrexate Drug
- Methylprednisone Drug
- C. albicans Biological
- Tetanus toxoid adsorbed booster vaccine Biological
- 23-valent pneumococcal polysaccharide vaccine Biological
- Keyhole limpet hemocyanin Biological
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 23, 2006 (Actual)
- Primary completion
- Jan 31, 2008 (Actual)
- Completion
- May 28, 2012 (Actual)
- Last update posted
- Aug 10, 2017
2006 – 2012
United States locations
- U.S. sites
- 34
- U.S. states
- 21
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Univ of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Arizona Arthritis & Rheumatology Research, Pllc | Paradise Valley | Arizona | 85253 | — |
| Sun Valley Arthritis Center | Peoria | Arizona | 85381 | — |
| Desert Medical Advances | Palm Desert | California | 92260 | — |
| Inland Rheumatology; Clinical Trials, Inc. | Upland | California | 91786 | — |
| Arthritis Associates of South Florida | Delray Beach | Florida | 33484 | — |
| The Arthritis Center | Palm Harbor | Florida | 34684 | — |
| Center For Arthritis; Research Dept | South Miami | Florida | 33143 | — |
| Intermountain Orthopaedics | Boise | Idaho | 83702 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Univ of Chicago | Chicago | Illinois | 60637 | — |
| Evanston Northwestern Healthcare | Evanston | Illinois | — | — |
| Springfield Clinic | Springfield | Illinois | 62703 | — |
| Kentuckiana Center For Better Bone & Joint Healthx | Louisville | Kentucky | 40202 | — |
| Clinical Research Network | Slidell | Louisiana | 70458 | — |
| Johns Hopkins University; Rheumatology | Baltimore | Maryland | 21224 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Rheumatology, P.C.; Medical Arts Building | Kalamazoo | Michigan | 49009 | — |
| Borgess Research Institute | Kalamazoo | Michigan | 49048 | — |
| Justus Fiechtner MD - PP | Lansing | Michigan | 48910 | — |
| Center for Rheumatology, State Uni. of New York | Albany | New York | 12206 | — |
| Aair Research Center | Rochester | New York | 14618 | — |
| University of Rochester - Strong Memorial Hospital | Rochester | New York | 14642 | — |
| Physicians East Pa | Greenville | North Carolina | 27834 | — |
| Health Research of Oklahoma, Llc | Oklahoma City | Oklahoma | 73103 | — |
| Oregon Health Sciences Uni | Portland | Oregon | 97239 | — |
| Altoona Arthritis & Osteo Center | Duncansville | Pennsylvania | 16635 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Rheumatology Associates | Charleston | South Carolina | 29407 | — |
| Medical University of S. Carolina | Charleston | South Carolina | 29425 | — |
| Arthritis Associates | Hixson | Tennessee | 37343 | — |
| Arthritis Care & Diagnostic Center | Dallas | Texas | 75231-4406 | — |
| Arthritis Clinic of Northern Virginia | Arlington | Virginia | 22205 | — |
| Arthritis Northwest, Spokane | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00282308, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 10, 2017 · Synced Oct 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00282308 live on ClinicalTrials.gov.