Randomized On-X Anticoagulation Trial
Public ClinicalTrials.gov record NCT00291525. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Prospective Randomized On-X Anticoagulation Clinical Trial (PROACT)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Various patient groups with the On-X Valve can be maintained safely on lower doses of blood thinner(Coumadin®) or on antiplatelet drugs (aspirin/Plavix®) only rather than the standard dose of Coumadin and aspirin presently recommended by ACC/AHA or ACCP professional societies.
Study identification
- NCT ID
- NCT00291525
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 977 participants
Conditions and interventions
Conditions
Interventions
Device
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 6, 2006 (Actual)
- Primary completion
- Aug 8, 2023 (Actual)
- Completion
- Dec 29, 2023 (Actual)
- Last update posted
- Dec 24, 2024
2006 – 2023
United States locations
- U.S. sites
- 44
- U.S. states
- 26
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Tucson Medical Center | Tucson | Arizona | 85718 | — |
| Southern Arizona VA Medical Center | Tucson | Arizona | 85723 | — |
| Loma Linda University | Loma Linda | California | 92354 | — |
| Hartford Hospital | Hartford | Connecticut | 06102 | — |
| Christiana Health Care Services | Newark | Delaware | 19713 | — |
| Medstar Heart & Vascular Institute | Washington D.C. | District of Columbia | 20010 | — |
| Shands Hospital - University of Florida | Gainesville | Florida | 32610 | — |
| Cardiac Surgical Associates | Kissimmee | Florida | 34741 | — |
| South Florida Heart & Lung | Miami | Florida | 33133 | — |
| Florida Hospital | Orlando | Florida | 32803 | — |
| Emory University | Atlanta | Georgia | 30365 | — |
| St. Francis Heart Center | Indianapolis | Indiana | 46237 | — |
| Cotton-O'Neil Clinical Research Center | Topeka | Kansas | 66604 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Maine Medical Center | Portland | Maine | 04102 | — |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| St. Joseph Mercy Hospital | Ann Arbor | Michigan | 48197 | — |
| Mid America Heart institute | Kansas City | Missouri | 64111 | — |
| Barnes Jewish Hospital - Washington University | St Louis | Missouri | 63110 | — |
| New Mexico Heart Institute | Albuquerque | New Mexico | 87102 | — |
| St. Luke's Roosevelt | New York | New York | 10025 | — |
| Montefiore Medical Center | New York | New York | 10461 | — |
| WakeMed | Raleigh | North Carolina | 27610 | — |
| Duke University Medical Center | Raleigh | North Carolina | 27710 | — |
| Novant Health | Winston-Salem | North Carolina | 27104 | — |
| University Hospital - Cleveland | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Ohio State University Medical Center | Columbus | Ohio | 43210 | — |
| University of Oklahoma/VA Oklahoma City | Oklahoma City | Oklahoma | 73104 | — |
| Providence Heart & Vascular Institute | Portland | Oregon | 97220 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213 | — |
| Baylor Research Institute | Dallas | Texas | 75226 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| University of Texas Health Science Center at Houston | Houston | Texas | 77030 | — |
| Texas Heart Institute | Houston | Texas | 77225 | — |
| Texas Cardiac Center | Lubbock | Texas | 79410 | — |
| Baylor Scott & White - Plano | Plano | Texas | 78093 | — |
| Mary Washington Hospital | Fredericksburg | Virginia | 22401 | — |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| Swedish Medical Center | Seattle | Washington | 98122 | — |
| MultiCare Health System | Tacoma | Washington | 98415 | — |
| West Virginia University | Morgantown | West Virginia | 26506 | — |
| St. Luke's Aurora Health Care | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00291525, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 24, 2024 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00291525 live on ClinicalTrials.gov.