A Study of the Effectiveness of Sitaxsentan Sodium in Patients With Diastolic Heart Failure
Public ClinicalTrials.gov record NCT00303498. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 2 RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED EXPLORATORY EFFICACY STUDY OF SITAXSENTAN SODIUM TO IMPROVE IMPAIRED EXERCISE TOLERANCE IN SUBJECTS WITH DIASTOLIC HEART FAILURE
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The aim of this study was to determine whether long-term (≥ 6 months at the target dose) blockade of ETA receptors using sitaxsentan showed functional benefit in subjects with chronic Heart Failure and an Left Ventricular Ejection Fraction ≥50%.
Study identification
- NCT ID
- NCT00303498
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 200 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 27, 2006 (Actual)
- Primary completion
- May 1, 2008 (Actual)
- Completion
- May 1, 2008 (Actual)
- Last update posted
- Jan 4, 2023
2006 – 2008
United States locations
- U.S. sites
- 50
- U.S. states
- 30
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Mobile Heart Specialists, PC | Mobile | Alabama | 36608 | — |
| Preventative and Research Cardiloogy Providence Hospital | Mobile | Alabama | 36608 | — |
| Central Arkansas Veterans HCS | Little Rock | Alaska | 72205 | — |
| Arizona Pulmonary Specialists, LTD | Phoenix | Arizona | 85013 | — |
| Parkview Research Center | Tucson | Arizona | 85715 | — |
| Southwest Heart | Tucson | Arizona | 85715 | — |
| University of Arkansas for Medical Services/Cardiology Department | Little Rock | Arkansas | 72205 | — |
| University of Southern California Medical Center | Los Angeles | California | 90033 | — |
| Orange County Heart Institute and Research Center | Orange | California | 92868 | — |
| Sacramento Heart & Vascular Medical Associates | Sacramento | California | 95825 | — |
| University of California | San Diego | California | 92103-8411 | — |
| Yale University School of Medicine, Cardiovascular Medicine | New Haven | Connecticut | 06510 | — |
| Capital City Research, CCRW | Washington D.C. | District of Columbia | 20011 | — |
| Florida Heart Group Pa | Orlando | Florida | 32803 | — |
| The University of Chicago | Chicago | Illinois | 60637 | — |
| Methodist Medical Center | Peoria | Illinois | 61606 | — |
| Cardiovascular Consultants of Maine | Auburn | Maine | 04210 | — |
| Massachusetts General Hospital Pulmonary and Critical Care Unit | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| VA Med Ctr Minneapolis | Minneapolis | Minnesota | 55417-2309 | — |
| St. Louis University Hospital | St Louis | Missouri | 63110 | — |
| Washington Univ. School of Medicine | St Louis | Missouri | 63110 | — |
| Nebraska Heart Institute | Lincoln | Nebraska | 68526 | — |
| Catholic Medical Center d/b/a New England Heart Institute | Manchester | New Hampshire | 03102 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| Buffalo Cardipul Assoc | Buffalo | New York | 14221-5838 | — |
| Columbia University Medical Center, New York Presbyterian Hospital | New York | New York | 10032 | — |
| Capital Cardiology Associates | Troy | New York | 112180 | — |
| Mid Carolina Cardiology | Charlotte | North Carolina | 28204-3288 | — |
| Mid Carolina Cardiology | Huntersville | North Carolina | 28078 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157-1045 | — |
| The Ohio State University | Columbus | Ohio | 43210-1252 | — |
| Oklahoma Foundation for Cardiovascular Research | Oklahoma City | Oklahoma | 73120 | — |
| The Oregon Clinic | Portland | Oregon | 97220 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Advanced Heart Failure & Transplant Center | Philadelphia | Pennsylvania | 19140 | — |
| Albert Einstein Medical Center | Philadelphia | Pennsylvania | 19141 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| RHJ VA Medical Center | Charleston | South Carolina | 29401 | — |
| Black Hills Clinical Research Center | Rapid City | South Dakota | 57701 | — |
| Stern Cardiovascular Center | Germantown | Tennessee | 38138 | — |
| Baylor College of Medicine Pulmonary Section | Houston | Texas | 77030 | — |
| Kelsey Seybold Clinic | Houston | Texas | 77030 | — |
| Methodist DeBakey Heart Center | Houston | Texas | 77030 | — |
| Intermountain Medical Center (a.k.a. LDS Hospital) | Murray | Utah | 84157 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| Fletcher Allen Health Care | Burlington | Vermont | 05401 | — |
| Medical College of Virginia | Richmond | Virginia | 23298 | — |
| University of Wisconsin Hospital & Clinics | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00303498, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 4, 2023 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00303498 live on ClinicalTrials.gov.