ClinicalTrials.gov record
Motexafin Gadolinium, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma
ClinicalTrials.gov ID: NCT00305864
Public ClinicalTrials.gov record NCT00305864. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE I/II TRIAL OF TEMOZOLOMIDE, MOTEXAFIN GADOLINIUM, AND 60 GY FRACTIONATED RADIATION FOR NEWLY DIAGNOSED SUPRATENTORIAL GLIOBLASTOMA MULTIFORME
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase I/II trial is studying the side effects and best dose of motexafin gadolinium when given together with temozolomide and radiation therapy and to see how well they work in treating patients with newly diagnosed supratentorial glioblastoma multiforme or gliosarcoma. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Motexafin gadolinium may help temozolomide work better by making tumor cells more sensitive to the drug. Radiation therapy uses high-energy x-rays to kill tumor cells. Motexafin gadolinium may also make tumor cells more sensitive to radiation therapy. Giving motexafin gadolinium together with temozolomide and radition therapy may kill more tumor cells.
Study identification
- NCT ID
- NCT00305864
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 118 participants
Conditions and interventions
Interventions
- 3-Dimensional Conformal Radiation Therapy Radiation
- Motexafin Gadolinium Drug
- Temozolomide Drug
Radiation · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 9, 2006 (Actual)
- Primary completion
- Feb 16, 2011 (Actual)
- Completion
- Mar 15, 2011 (Actual)
- Last update posted
- Mar 5, 2018
2006 – 2011
United States locations
- U.S. sites
- 106
- U.S. states
- 20
- U.S. cities
- 76
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mobile Infirmary Medical Center | Mobile | Alabama | 36607 | — |
| Arizona Oncology Services Foundation | Scottsdale | Arizona | 85260 | — |
| The University of Arizona Medical Center-University Campus | Tucson | Arizona | 85724 | — |
| East Bay Radiation Oncology Center | Castro Valley | California | 94546 | — |
| Eden Hospital Medical Center | Castro Valley | California | 94546 | — |
| Valley Medical Oncology Consultants-Castro Valley | Castro Valley | California | 94546 | — |
| Bay Area Breast Surgeons Inc | Emeryville | California | 94608 | — |
| Valley Medical Oncology Consultants-Fremont | Fremont | California | 94538 | — |
| Saint Rose Hospital | Hayward | California | 94545 | — |
| Los Angeles County-USC Medical Center | Los Angeles | California | 90033 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Contra Costa Regional Medical Center | Martinez | California | 94553-3156 | — |
| El Camino Hospital | Mountain View | California | 94040 | — |
| Highland General Hospital | Oakland | California | 94602 | — |
| Alta Bates Summit Medical Center - Summit Campus | Oakland | California | 94609 | — |
| Bay Area Tumor Institute | Oakland | California | 94609 | — |
| Hematology and Oncology Associates-Oakland | Oakland | California | 94609 | — |
| Tom K Lee Inc | Oakland | California | 94609 | — |
| Stanford Cancer Institute Palo Alto | Palo Alto | California | 94304 | — |
| Valley Care Health System - Pleasanton | Pleasanton | California | 94588 | — |
| Valley Medical Oncology Consultants | Pleasanton | California | 94588 | — |
| Doctors Medical Center- JC Robinson Regional Cancer Center | San Pablo | California | 94806 | — |
| Denver Veterans Administration Medical Center | Denver | Colorado | 80220 | — |
| University of Florida Health Science Center - Gainesville | Gainesville | Florida | 32610 | — |
| University of Florida Health Science Center - Jacksonville | Jacksonville | Florida | 32209 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Rush - Copley Medical Center | Aurora | Illinois | 60504 | — |
| Saint Joseph Medical Center | Bloomington | Illinois | 61701 | — |
| Graham Hospital Association | Canton | Illinois | 61520 | — |
| Memorial Hospital | Carthage | Illinois | 62321 | — |
| Heartland Cancer Research NCORP | Decatur | Illinois | 62526 | — |
| Eureka Hospital | Eureka | Illinois | 61530 | — |
| Galesburg Cottage Hospital | Galesburg | Illinois | 61401 | — |
| Illinois CancerCare-Galesburg | Galesburg | Illinois | 61401 | — |
| Western Illinois Cancer Treatment Center | Galesburg | Illinois | 61401 | — |
| Mason District Hospital | Havana | Illinois | 62644 | — |
| Hopedale Medical Complex - Hospital | Hopedale | Illinois | 61747 | — |
| Joliet Oncology-Hematology Associates Limited | Joliet | Illinois | 60435 | — |
| Kewanee Hospital | Kewanee | Illinois | 61443 | — |
| Mcdonough District Hospital | Macomb | Illinois | 61455 | — |
| Bromenn Regional Medical Center | Normal | Illinois | 61761 | — |
| Community Cancer Center Foundation | Normal | Illinois | 61761 | — |
| Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | 61350 | — |
| Ottawa Regional Hospital and Healthcare Center | Ottawa | Illinois | 61350 | — |
| OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | 61554 | — |
| Pekin Hospital | Pekin | Illinois | 61554 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61603 | — |
| Proctor Hospital | Peoria | Illinois | 61614 | — |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | — |
| OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | 61615 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Illinois Valley Hospital | Peru | Illinois | 61354 | — |
| Valley Radiation Oncology | Peru | Illinois | 61354 | — |
| Perry Memorial Hospital | Princeton | Illinois | 61356 | — |
| Saint Margaret's Hospital | Spring Valley | Illinois | 61362 | — |
| Franciscan Saint Margaret Health-Hammond Campus | Hammond | Indiana | 46320 | — |
| Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| Franciscan Saint Anthony Health-Michigan City | Michigan City | Indiana | 46360 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Michigan Cancer Research Consortium NCORP | Ann Arbor | Michigan | 48106 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48106 | — |
| Beaumont Hospital-Dearborn | Dearborn | Michigan | 48124 | — |
| Saint John Hospital and Medical Center | Detroit | Michigan | 48236 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| Genesys Regional Medical Center-West Flint Campus | Flint | Michigan | 48532 | — |
| McLaren Cancer Institute-Flint | Flint | Michigan | 48532 | — |
| Allegiance Health | Jackson | Michigan | 49201 | — |
| Sparrow Hospital | Lansing | Michigan | 48912 | — |
| Saint Mary Mercy Hospital | Livonia | Michigan | 48154 | — |
| Saint Joseph Mercy Oakland | Pontiac | Michigan | 48341 | — |
| Lake Huron Medical Center | Port Huron | Michigan | 48060 | — |
| Saint Mary's of Michigan | Saginaw | Michigan | 48601 | — |
| Saint John Macomb-Oakland Hospital | Warren | Michigan | 48093 | — |
| Mercy Hospital-Joplin | Joplin | Missouri | 64804 | — |
| CHI Health Good Samaritan | Kearney | Nebraska | 68847 | — |
| John F Kennedy Medical Center | Edison | New Jersey | 08818 | — |
| Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08903 | — |
| Rutgers New Jersey Medical School | Newark | New Jersey | 07101 | — |
| Duke Women's Cancer Care Raleigh | Raleigh | North Carolina | 27607 | — |
| Rex Cancer Center | Raleigh | North Carolina | 27607 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | 19010 | — |
| Paoli Memorial Hospital | Paoli | Pennsylvania | 19301 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| Main Line Health NCORP | Wynnewood | Pennsylvania | 19096 | — |
| Audie L Murphy Veterans Affairs Hospital | San Antonio | Texas | 78209 | — |
| Cancer Therapy and Research Center at The UT Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| University Hospital | San Antonio | Texas | 78229 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah | 84003 | — |
| Sandra L Maxwell Cancer Center | Cedar City | Utah | 84720 | — |
| Cottonwood Hospital Medical Center | Murray | Utah | 84107 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| McKay-Dee Hospital Center | Ogden | Utah | 84403 | — |
| Utah Valley Regional Medical Center | Provo | Utah | 84604 | — |
| Intermountain Health Care | Salt Lake City | Utah | 84103 | — |
| Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | 84106 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Dixie Medical Center Regional Cancer Center | St. George | Utah | 84770 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Wheeling Hospital/Schiffler Cancer Center | Wheeling | West Virginia | 26003 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
| Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00305864, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 5, 2018 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00305864 live on ClinicalTrials.gov.