Study of XL784 in Patients With Albuminuria Due to Diabetic Nephropathy
Public ClinicalTrials.gov record NCT00312780. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A Randomized, Double-Blind, Placebo-Controlled Study of XL784 Administered Orally to Subjects With Albuminuria Due to Diabetic Nephropathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This clinical study is being conducted at multiple sites to determine the activity, safety and tolerability of XL784 when given daily to patients with albuminuria due to diabetic nephropathy. XL784 is a small molecule reno-protective metalloproteinase inhibitor, inhibiting both ADAMs (including ADAM10, a target of significant interest because of its important role in blood vessel formation and cell proliferation, and ADAM17/TACE, activation of which has been associated with renal deterioration) and MMPs (including MMP-2 and MMP-9). XL784 was specifically optimized to be MMP-1 sparing, which may be clinically significant because inhibition of MMP-1 has been hypothesized to be associated with musculoskeletal toxicity.
Study identification
- NCT ID
- NCT00312780
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 125 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2006 (Type not available)
- Primary completion
- Oct 2007 (Actual)
- Completion
- Dec 2007 (Actual)
- Last update posted
- Feb 23, 2010
2006 – 2007
United States locations
- U.S. sites
- 45
- U.S. states
- 27
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Parkway Medical Center | Birmingham | Alabama | 35215 | — |
| Winston Technology, Inc. | Haleyville | Alabama | 35565 | — |
| Redpoint Research | Phoenix | Arizona | 85209 | — |
| International Clinical Research Network, Inc. | Chula Vista | California | 91911 | — |
| Scripps Clinic, Torrey Pines, Division of Nephrology | La Jolla | California | 92037 | — |
| National Research Institute | Los Angeles | California | 90057 | — |
| West Los Angeles VA Medical Center | Los Angeles | California | 90073 | — |
| UCLA Medical Center, Center for the Health Sciences | Los Angeles | California | 90095 | — |
| Arroyo Research Inc. | Pasadena | California | 91105 | — |
| Western Nephrology and Metabolic Bone Disease, PC | Lakewood | Colorado | 80214 | — |
| Western Nephrology and Metabolic Bone Disease, PC | Thornton | Colorado | 80260 | — |
| Soundview Research Associates | Norwalk | Connecticut | 06850 | — |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | — |
| MedStar Clinical Research Center | Washington D.C. | District of Columbia | 20003 | — |
| Clinical Research of South Florida | Coral Gables | Florida | 33134 | — |
| The Center for Diabetes and Endocrine Care | Hollywood | Florida | 33021 | — |
| FPA Clinical Research | Kissimmee | Florida | 34741 | — |
| Pines Clinical Research, Inc. | Pembroke Pines | Florida | 33028 | — |
| Rocky Mountain Diabetes and Osteoporosis Center, PA | Idaho Falls | Idaho | 83404 | — |
| Renal Associate of Baton Rouge | Baton Rouge | Louisiana | 70809 | — |
| Intermed | Portland | Maine | 04102 | — |
| MODEL Clinical Research | Baltimore | Maryland | 21204 | — |
| Renal Unit, Joslin Diabetes Center | Boston | Massachusetts | 02215 | — |
| Fallon Clinic Inc. at Worcester Medical Center, Department of Nephrology | Worchester | Massachusetts | 01608 | — |
| Center for Urban and African American Health | Detroit | Michigan | 48201 | — |
| South Mississippi Nephrology | Gulfport | Mississippi | 39501 | — |
| Kansas City VA Medical Center | Kansas City | Missouri | 64128 | — |
| Clayton Medical Research | St Louis | Missouri | 63117 | — |
| Creighton Dibetes Center | Omaha | Nebraska | 68131 | — |
| University of Nebraska Medical Center - Nephrology | Omaha | Nebraska | 68198 | — |
| LAND Clinical Studies, LLC | West Caldwell | New Jersey | 07006 | — |
| Montefiore Medical Center | The Bronx | New York | 10461 | — |
| Duke South | Durham | North Carolina | 27710 | — |
| Division of Nephrology/Department of Medicine, Case Western Rserve University, MetroHealth Medical Center Campus | Cleveland | Ohio | 44109 | — |
| The Ohio State University Medical Center, Division of Nephrology | Columbus | Ohio | 43210 | — |
| COR Clinical Research, LLC | Oklahoma City | Oklahoma | 73103 | — |
| Clinical Research Institute of Southern Oregon, PC | Medford | Oregon | 97504 | — |
| Mountain View Clinical Research, Inc. | Greer | South Carolina | 29651 | — |
| Nephrology Associates, PC | Nashville | Tennessee | 37205 | — |
| Heartland Medical, PC | New Tazewell | Tennessee | 37825 | — |
| Diabetes Center of the Southwest | Midland | Texas | 79705 | — |
| dgd Research | San Antonio | Texas | 78229 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| University of Virginia Health System, Nephrology Division | Charlottesville | Virginia | 22908 | — |
| Zablocki Veterans Affairs Medical Center, Nephrology Section | Milwaukee | Wisconsin | 53295 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00312780, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 23, 2010 · Synced Nov 10, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00312780 live on ClinicalTrials.gov.