Bevacizumab, Radiation Therapy, and Combination Chemotherapy in Treating Patients Who Are Undergoing Surgery for Locally Advanced Nonmetastatic Rectal Cancer
Public ClinicalTrials.gov record NCT00321685. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase II Study of Preoperative Radiation With Concurrent Capecitabine, Oxaliplatin and Bevacizumab Followed by Surgery and Postoperative 5-FU, Leucovorin, Oxaliplatin (FOLFOX) and Bevacizumab in Patients With Locally Advanced Rectal Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase II trial studies how well giving bevacizumab, radiation therapy, and combination chemotherapy works in treating patients who are undergoing surgery for locally advanced nonmetastatic rectal cancer. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some find tumor cells and kill them or carry tumor-killing substances to them. Others interfere with the ability of tumor cells to grow and spread. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as capecitabine, may make tumor cells more sensitive to radiation therapy. Drugs used in chemotherapy, such as capecitabine, oxaliplatin, fluorouracil, and leucovorin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving bevacizumab together with radiation therapy and combination chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving bevacizumab together with combination chemotherapy after surgery may kill any tumor cells that remain after surgery.
Study identification
- NCT ID
- NCT00321685
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 57 participants
Conditions and interventions
Interventions
- Bevacizumab Biological
- Capecitabine Drug
- Fluorouracil Drug
- Leucovorin Calcium Drug
- Oxaliplatin Drug
- Radiation Therapy Radiation
- Therapeutic Conventional Surgery Procedure
Biological · Drug · Radiation + 1 more
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 25, 2006 (Actual)
- Primary completion
- Aug 12, 2013 (Actual)
- Completion
- Feb 11, 2019 (Actual)
- Last update posted
- Mar 27, 2019
2006 – 2019
United States locations
- U.S. sites
- 107
- U.S. states
- 17
- U.S. cities
- 69
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | — |
| The Hospital of Central Connecticut | New Britain | Connecticut | 06050 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Atlanta VA Medical Center | Decatur | Georgia | 30033 | — |
| Medical Center of Central Georgia | Macon | Georgia | 31201 | — |
| Rush - Copley Medical Center | Aurora | Illinois | 60504 | — |
| MacNeal Hospital and Cancer Center | Berwyn | Illinois | 60402 | — |
| Hematology and Oncology Associates | Chicago | Illinois | 60611 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Jesse Brown Veterans Affairs Medical Center | Chicago | Illinois | 60612 | — |
| Mercy Hospital and Medical Center | Chicago | Illinois | 60616 | — |
| Swedish Covenant Hospital | Chicago | Illinois | 60625 | — |
| Presence Saint Joseph Hospital-Chicago | Chicago | Illinois | 60657 | — |
| Saint Anthony Memorial Hospital | Effingham | Illinois | 62401 | — |
| Hematology Oncology Associates of Illinois-Highland Park | Highland Park | Illinois | 60035 | — |
| Hinsdale Hematology Oncology Associates Incorporated | Hinsdale | Illinois | 60521 | — |
| Midwest Center for Hematology Oncology | Joliet | Illinois | 60432 | — |
| Joliet Oncology-Hematology Associates Limited | Joliet | Illinois | 60435 | — |
| NorthShore Hematology Oncology-Libertyville | Libertyville | Illinois | 60048 | — |
| Garneau, Stewart C MD (UIA Investigator) | Moline | Illinois | 61265 | — |
| Porubcin, Michael MD (UIA Investigator) | Moline | Illinois | 61265 | — |
| Sharis, Christine M MD (UIA Investigator) | Moline | Illinois | 61265 | — |
| Spector, David MD (UIA Investigator) | Moline | Illinois | 61265 | — |
| Stoffel, Thomas J MD (UIA Investigator) | Moline | Illinois | 61265 | — |
| Trinity Medical Center | Moline | Illinois | 61265 | — |
| Vigliotti, Antonio, P.G. M.D. (UIA Investigator) | Moline | Illinois | 61265 | — |
| DuPage Medical Group-Ogden | Naperville | Illinois | 60563 | — |
| Illinois Cancer Specialists-Niles | Niles | Illinois | 60714 | — |
| Edward H Kaplan MD and Associates | Skokie | Illinois | 60076 | — |
| Hematology Oncology Associates of Illinois - Skokie | Skokie | Illinois | 60076 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Franciscan Saint Anthony Health-Michigan City | Michigan City | Indiana | 46360 | — |
| Constantinou, Costas L MD (UIA Investigator) | Bettendorf | Iowa | 52722 | — |
| Siouxland Regional Cancer Center | Sioux City | Iowa | 51101 | — |
| Mercy Medical Center-Sioux City | Sioux City | Iowa | 51102 | — |
| Saint Luke's Regional Medical Center | Sioux City | Iowa | 51104 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Borgess Medical Center | Kalamazoo | Michigan | 49048 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Fairview-Southdale Hospital | Edina | Minnesota | 55435 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Hutchinson Area Health Care | Hutchinson | Minnesota | 55350 | — |
| Meeker County Memorial Hospital | Litchfield | Minnesota | 55355 | — |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | — |
| Saint John's Hospital - Healtheast | Maplewood | Minnesota | 55109 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Virginia Piper Cancer Institute | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | — |
| Metro Minnesota Community Oncology Research Consortium | Saint Louis Park | Minnesota | 55416 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Saint Joseph's Hospital - Healtheast | Saint Paul | Minnesota | 55102 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Saint Francis Regional Medical Center | Shakopee | Minnesota | 55379 | — |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | — |
| Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | 55125 | — |
| Woodwinds Health Campus | Woodbury | Minnesota | 55125 | — |
| Nebraska Cancer Research Center | Lincoln | Nebraska | 68510 | — |
| Missouri Valley Cancer Consortium | Omaha | Nebraska | 68106 | — |
| Alegent Health Immanuel Medical Center | Omaha | Nebraska | 68122 | — |
| Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | 68124 | — |
| Creighton University Medical Center | Omaha | Nebraska | 68131 | — |
| Virtua Memorial | Mount Holly | New Jersey | 08060 | — |
| Sparta Cancer Treatment Center | Sparta | New Jersey | 07871 | — |
| Virtua Voorhees | Voorhees Township | New Jersey | 08043 | — |
| Inspira Medical Center Woodbury | Woodbury | New Jersey | 08096 | — |
| Montefiore Medical Center-Wakefield Campus | The Bronx | New York | 10466 | — |
| Montefiore Medical Center - Moses Campus | The Bronx | New York | 10467 | — |
| Summa Akron City Hospital/Cooper Cancer Center | Akron | Ohio | 44304 | — |
| Summa Barberton Hospital | Barberton | Ohio | 44203 | — |
| Mary Rutan Hospital | Bellefontaine | Ohio | 43311 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Grant Medical Center | Columbus | Ohio | 43215 | — |
| Mount Carmel Health Center West | Columbus | Ohio | 43222 | — |
| Doctors Hospital | Columbus | Ohio | 43228 | — |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | — |
| Fairfield Medical Center | Lancaster | Ohio | 43130 | — |
| Saint Rita's Medical Center | Lima | Ohio | 45801 | — |
| Marietta Memorial Hospital | Marietta | Ohio | 45750 | — |
| Licking Memorial Hospital | Newark | Ohio | 43055 | — |
| Springfield Regional Medical Center | Springfield | Ohio | 45505 | — |
| Saint Ann's Hospital | Westerville | Ohio | 43081 | — |
| Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | 43701 | — |
| Natalie Warren Bryant Cancer Center at Saint Francis | Tulsa | Oklahoma | 74136 | — |
| Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | 18103 | — |
| Mercy Fitzgerald Hospital | Darby | Pennsylvania | 19023-1291 | — |
| Pocono Medical Center | East Stroudsburg | Pennsylvania | 18301 | — |
| Ephrata Cancer Center | Ephrata | Pennsylvania | 17522 | — |
| Riddle Memorial Hospital | Media | Pennsylvania | 19063 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Aria Health-Torresdale Campus | Philadelphia | Pennsylvania | 19114 | — |
| Einstein Medical Center Philadelphia | Philadelphia | Pennsylvania | 19141 | — |
| Hematology and Oncology Associates of North East Pennsylvania | Scranton | Pennsylvania | 18508 | — |
| Associates In Hematology Oncology PC-Upland | Upland | Pennsylvania | 19013 | — |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | — |
| Avera McKennan Hospital and University Health Center | Sioux Falls | South Dakota | 57105 | — |
| Medical X-Ray Center | Sioux Falls | South Dakota | 57105 | — |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | — |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00321685, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 27, 2019 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00321685 live on ClinicalTrials.gov.