Efficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in Combination With an Antidepressant in the Treatment of Major Depressive Disorders
Public ClinicalTrials.gov record NCT00326105. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Double-Blind, Randomized, Parallel-Group, Placebo- Controlled Phase III Study of the Efficacy and Safety of Quetiapine Fumarate Sustained Release (Seroquel SRTM) in Combination With an Antidepressant in the Treatment of Patients With Major Depressive Disorder With Inadequate Response to an Antidepressant Treatment (PEARL STUDY)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy of quetiapine SR in combination with an antidepressant versus an antidepressant alone in patients with MDD with inadequate response to an antidepressant treatment. PLEASE NOTE: Seroquel SR and Seroquel XR refer to the same formulation. The SR designation was changed to XR after consultation with FDA.
Study identification
- NCT ID
- NCT00326105
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 450 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 2006 (Type not available)
- Primary completion
- Not listed
- Completion
- Jul 2007 (Actual)
- Last update posted
- Mar 25, 2009
2006 – 2007
United States locations
- U.S. sites
- 56
- U.S. states
- 25
- U.S. cities
- 56
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Phoenix | Arizona | — | — |
| Research Site | El Centro | California | — | — |
| Research Site | Irvine | California | — | — |
| Research Site | Oceanside | California | — | — |
| Research Site | San Diego | California | — | — |
| Research Site | Pueblo | Colorado | — | — |
| Research Site | Coral Springs | Florida | — | — |
| Research Site | DeLand | Florida | — | — |
| Research Site | Gainsville | Florida | — | — |
| Research Site | Hialeah | Florida | — | — |
| Research Site | Jacksonville | Florida | — | — |
| Research Site | Miami | Florida | — | — |
| Research Site | Orlando | Florida | — | — |
| Research Site | West Palm Beach | Florida | — | — |
| Research Site | Atlanta | Georgia | — | — |
| Research Site | Roswell | Georgia | — | — |
| Research Site | Hoffman Estates | Illinois | — | — |
| Research Site | Naperville | Illinois | — | — |
| Research Site | Oak Brook | Illinois | — | — |
| Research Site | Indianapolis | Indiana | — | — |
| Research Site | Lafayette | Indiana | — | — |
| Research Site | Valparaiso | Indiana | — | — |
| Research Site | Prairie Village | Kansas | — | — |
| Research Site | Wichita | Kansas | — | — |
| Research Site | Shreveport | Louisiana | — | — |
| Research SIte | Glen Burnie | Maryland | — | — |
| Research Site | Braintree | Massachusetts | — | — |
| Research Site | Springfield | Massachusetts | — | — |
| Research Site | Clinton Township | Michigan | — | — |
| Research Site | Kalamazoo | Michigan | — | — |
| Research Site | Royal Oak | Michigan | — | — |
| Research Site | Saint Charles | Missouri | — | — |
| Research Site | St Louis | Missouri | — | — |
| Research Site | Cherry Hill | New Jersey | — | — |
| Research Site | Clementon | New Jersey | — | — |
| Research Site | Cedarhurst | New York | — | — |
| Research Site | New York | New York | — | — |
| Research Site | Olean | New York | — | — |
| Research Site | Rochester | New York | — | — |
| Research Site | Staten Island | New York | — | — |
| Research Site | Beechwood | Ohio | — | — |
| Research Site | Toledo | Ohio | — | — |
| Research Site | Norman | Oklahoma | — | — |
| Research Site | Oklahoma City | Oklahoma | — | — |
| Research Site | Philadelphia | Pennsylvania | — | — |
| Research Site | Lincoln | Rhode Island | — | — |
| Research Site | Columbia | South Carolina | — | — |
| Research Site | Memphis | Tennessee | — | — |
| Research Site | Friendswood | Texas | — | — |
| Research Site | Houston | Texas | — | — |
| Research Site | San Antonio | Texas | — | — |
| Research SIte | Wichita Falls | Texas | — | — |
| Research Site | Salt Lake City | Utah | — | — |
| Research Site | Arlington | Virginia | — | — |
| Research Site | Richmond | Virginia | — | — |
| Research Site | Bellevue | Washington | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00326105, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 25, 2009 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00326105 live on ClinicalTrials.gov.