DORADO - Fixed Doses of Darusentan as Compared to Placebo in Resistant Hypertension
Public ClinicalTrials.gov record NCT00330369. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
DORADO - A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Parallel Group Study to Evaluate the Efficacy and Safety of Fixed Doses of Darusentan in Subjects With Resistant Systolic Hypertension Receiving Combination Therapy With Three or More Antihypertensive Drugs, Including a Diuretic (Protocol DAR-311)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a research study of a new experimental drug called darusentan. Darusentan is not currently approved by the U.S. Food and Drug Administration (FDA) for use in the United States, which means that a doctor cannot prescribe this drug. The purpose of this study is to determine if darusentan is effective in reducing systolic blood pressure in subjects with resistant systolic hypertension, despite treatment with full doses of three or more antihypertensive drugs, including a diuretic.
Study identification
- NCT ID
- NCT00330369
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 352 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 35 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2006 (Type not available)
- Primary completion
- Jan 2009 (Actual)
- Completion
- Jan 2009 (Actual)
- Last update posted
- Mar 18, 2014
2006 – 2009
United States locations
- U.S. sites
- 67
- U.S. states
- 27
- U.S. cities
- 65
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UAB Hypertension Program | Birmingham | Alabama | 35294 | — |
| Comprehensive Heart Failure Center | Mobile | Alabama | 36608 | — |
| Canyon Clinical Research | Tucson | Arizona | 85712 | — |
| Chrishard Medical Group | Inglewood | California | 90301 | — |
| VA Medical Center - WLA | Los Angeles | California | 90073 | — |
| Sacramento Heart and Vascular | Sacramento | California | 95825 | — |
| Apex Research Institute | Santa Ana | California | 92705 | — |
| Complete Renal Care | Denver | Colorado | 80220 | — |
| Connecticut Clinical Research, LLC | Bridgeport | Connecticut | 06606 | — |
| MedStar Diabetes Institute at Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Deerfield Beach Cardiology Associates | Deerfield Beach | Florida | 33442 | — |
| White-Wilson Medical Center | Fort Walton Beach | Florida | 32569 | — |
| AMK Research | Gainsville | Florida | 32601 | — |
| A.G.A. Clinical Trials | Hialeah | Florida | 33012 | — |
| Jacksonville Center for Clinical | Jacksonville | Florida | 32216 | — |
| Ricardo A. Bedoya, Cardiology | Jupiter | Florida | 33458 | — |
| International Research Association | Miami | Florida | 33156 | — |
| Cardiovascular Center of Sarasota | Sarasota | Florida | 34239 | — |
| Tampa Bay Nephrology | Tampa | Florida | 33603 | — |
| Metabolic Research Institute, Inc. | West Palm Beach | Florida | 33401 | — |
| Global Research Partners | Calhoun | Georgia | 30701 | — |
| Kula Research | Honolulu | Hawaii | 96816 | — |
| Chicago Heart & Vein Clinic | Elk Grove Village | Illinois | 60007 | — |
| Evanston Northwestern Healthcare | Evanston | Illinois | 60201 | — |
| Clinical Investigation Specialists, Inc. | Gurnee | Illinois | 60031 | — |
| Midwest Heart Foundation | Lombard | Illinois | 60148 | — |
| American Clinical Research LLC | Marrero | Louisiana | 70072 | — |
| Medical Research Institute | Slidell | Louisiana | 70458 | — |
| Maine Research Associates | Auburn | Maine | 04210 | — |
| Cardiovascular Consultants of Maine | Scarborough | Maine | 04074 | — |
| MODEL Clinical Research | Baltimore | Maryland | 21204 | — |
| Maryland Medical Research/Og Medical Center | Oxon Hill | Maryland | 20745 | — |
| Clinical Associates | Reisterstown | Maryland | 21136 | — |
| Rockville Internal Medicine Group | Rockville | Maryland | 20854 | — |
| Professional Clinical Research | Benzonia | Michigan | 49616 | — |
| Nephrology and Hypertension / Hurley Medical Center | Flint | Michigan | 48503 | — |
| Professional Clinical Research | Interlochen | Michigan | 49643 | — |
| Specialty Medical Center | Pahrump | Nevada | 89048 | — |
| Bronx VA Medical Center / Mt. Sinai | The Bronx | New York | 10468 | — |
| Physicians East, PA | Greenville | North Carolina | 27834 | — |
| The Lindner Clinical Trial Center | Cincinnati | Ohio | 45219 | — |
| West Coast Cardiology Associates | Fairview Park | Ohio | 44125 | — |
| COR Clinical Research | Oklahoma City | Oklahoma | 73003 | — |
| Southwest Cardiology Associates | Oklahoma City | Oklahoma | 73109 | — |
| Sooner Clinical Research | Oklahoma City | Oklahoma | 73112 | — |
| Castlerock Clinical Research Consultants | Tulsa | Oklahoma | 74136 | — |
| Hillsboro Cardiology, PC | Hillsboro | Oregon | 97123 | — |
| Northeast Clinical Research Centers, Inc. | Allentown | Pennsylvania | 18103 | — |
| Heritage Cardiology Associates | Camp Hill | Pennsylvania | 17011 | — |
| Brandywine Clinical Research | Downingtown | Pennsylvania | 19335 | — |
| Green and Seidner Family Practice Associates | Lansdale | Pennsylvania | 19446 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| RI Hospital | Providence | Rhode Island | 02903 | — |
| Neem Research Group, Inc. | Columbia | South Carolina | 29201 | — |
| Internal Medicine & Industrial Medicine | DeSoto | Texas | 75115 | — |
| T&R Clinical, P.A. | Fort Worth | Texas | 76117 | — |
| Pri-Med Care | Lewisville | Texas | 75067 | — |
| Texas Tech University Health Sciences Center | Lubbock | Texas | 79430 | — |
| Diabetes Center of the Southwest | Midland | Texas | 79705 | — |
| The Bracane Company | Plano | Texas | 75093 | — |
| Innovative Clinical Trials | San Antonio | Texas | 78229 | — |
| Burke Internal Medicine, Inc. | Burke | Virginia | 22015 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| McGuire VA Medical Center | Richmond | Virginia | 22015 | — |
| Peninsula Inernal Medicine | Gig Harbor | Washington | 98335 | — |
| Liberty Research Center | Tacoma | Washington | 98405 | — |
| CAMC Clinical Trials Center | Charleston | West Virginia | 25304 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 48 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00330369, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 18, 2014 · Synced Oct 16, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00330369 live on ClinicalTrials.gov.