Safety and Efficacy of Different Combinations of Zonisamide-CR Plus Bupropion-SR to Treat Uncomplicated Obesity
Public ClinicalTrials.gov record NCT00339014. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Dose Parallel, Randomized, Placebo-Controlled, Multicenter Study of the Safety and Efficacy of Multiple Regimens of the Combination of Zonisamide CR Plus Bupropion SR in the Treatment of Subjects With Uncomplicated Obesity
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine which of seven combinations of Zonisamide CR and Bupropion SR gives the best weight loss and is safe and well tolerated for the treatment of obesity not associated with the complications of obesity such as diabetes. In a previous study, the combination of zonisamide and bupropion SR was shown to be effective for weight loss compared to either zonisamide, bupropion SR alone or placebo. It is thought that by adjusting the doses of each drug, giving zonisamide in a controlled release (CR) form and increasing the doses more slowly, more weight loss and less side effects can be attained.
Study identification
- NCT ID
- NCT00339014
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 611 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 60 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2006 (Type not available)
- Primary completion
- Aug 2007 (Actual)
- Completion
- Aug 2007 (Actual)
- Last update posted
- Apr 22, 2008
2006 – 2007
United States locations
- U.S. sites
- 15
- U.S. states
- 13
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| SelfCenter, PC | Fairhope | Alabama | 36532 | — |
| UCLA Center for Human Nutrition | Los Angeles | California | 90095 | — |
| Scripps Clinic Del Mar | San Diego | California | 92130 | — |
| Center for Human Nutrition University of Colorado Health Sciences Center | Denver | Colorado | 80220 | — |
| George Washington University Weight Management Program | Washington D.C. | District of Columbia | 20037 | — |
| CSRA Partners in Health, Inc | Augusta | Georgia | 30909 | — |
| Springfield Diabetes and Endocrine Center | Springfield | Illinois | 62704 | — |
| Pennington Biomedical Research Center | Baton Rouge | Louisiana | 70808 | — |
| Nutrition and Weight Mangement Center Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Center for Nutrition and Metabolic Diseases | Reno | Nevada | 89557 | — |
| Comprehensive Weight Control Program | New York | New York | 10021 | — |
| Center for Nutrition and Preventive Medicine | Charlotte | North Carolina | 28211 | — |
| MUSC Weight Mnagement Center | Charleston | South Carolina | 29425 | — |
| The Cooper Institute | Dallas | Texas | 75230 | — |
| Baylor Endocrine Center | Dallas | Texas | 75246 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00339014, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 22, 2008 · Synced Nov 2, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00339014 live on ClinicalTrials.gov.