APF530 or Aloxi (Palonosetron Hydrochloride) Combined With Dexamethasone in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy for Cancer
Public ClinicalTrials.gov record NCT00343460. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Pivotal Phase 3 Observer-Blind, Randomized Clinical Trial of the Efficacy and Safety of APF530 Compared to Aloxi For The Prevention of Acute-Onset and Delayed-Onset Chemotherapy-Induced Nausea and Vomiting Following The Administration of Either Moderately or Highly Emetogenic Chemotherapy Regimens
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase III trial is studying APF530 and dexamethasone to see how well they work compared with palonosetron and dexamethasone in preventing nausea and vomiting in patients receiving chemotherapy for cancer.
Study identification
- NCT ID
- NCT00343460
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,428 participants
Conditions and interventions
Interventions
- APF530 Drug
- dexamethasone Drug
- Palonosetron Hydrochloride Drug
- placebo Other
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years to 120 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2006 (Type not available)
- Primary completion
- Sep 2008 (Actual)
- Completion
- Feb 2009 (Actual)
- Last update posted
- Mar 2, 2026
2006 – 2009
United States locations
- U.S. sites
- 52
- U.S. states
- 27
- U.S. cities
- 49
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Anniston Oncology, PC | Anniston | Alabama | 36207 | — |
| Palo Verde Hematology Oncology - Glendale | Glendale | Arizona | 85304 | — |
| Arizona Clinical Research Center, Incorporated | Tucson | Arizona | 85715 | — |
| Arkansas Cancer Research Center at University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Pacific Cancer Medical Center, Incorporated | Anaheim | California | 92801 | — |
| Southbay Oncology / Hematology Medical Group | Campbell | California | 95008 | — |
| Compassionate Cancer Care Medical Group Incorporated - Corona | Corona | California | 92882 | — |
| Compassionate Cancer Care Medical Group Incorporated - Fountain Valley | Fountain Valley | California | 92708 | — |
| Advanced Research Management Services, Incorporated | Los Angeles | California | 90057 | — |
| Kenmar Research Institute | Los Angeles | California | 90057 | — |
| Medical Oncology Care Associates - Orange | Orange | California | 92868 | — |
| Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut | 06360 | — |
| Providence Hospital | Washington D.C. | District of Columbia | 20017 | — |
| Pasco Pinellas Cancer Center - New Port Richey | New Port Richey | Florida | 34689 | — |
| Innovative Medical Research of South Florida, Incorporated | North Miami Beach | Florida | 33179-4709 | — |
| Columbus Clinic, PC | Columbus | Georgia | 31901 | — |
| Clintell, Incorporated | Skokie | Illinois | 60077 | — |
| Investigative Clinical Research, LLC | Indianapolis | Indiana | 46254 | — |
| Cancer Center of Indiana | New Albany | Indiana | 47150 | — |
| Family Medicine of Vincennes Clinical Trial Center | Vincennes | Indiana | 47591 | — |
| Medical Center Vincennes | Vincennes | Indiana | 47591 | — |
| Kentucky Cancer Clinic - Hazard | Hazard | Kentucky | 41701 | — |
| Kentuckiana Cancer Institute, PLLC | Louisville | Kentucky | 40202 | — |
| Hematology-Medical Oncology Associates at Central Maine Comprehensive Cancer Center | Lewiston | Maine | 04240 | — |
| Mercy Medical Center | Baltimore | Maryland | 21202-2165 | — |
| Center for Cancer and Blood Disorders at Suburban Hospital | Bethesda | Maryland | 20817 | — |
| Center for Clinical Research at Washington County Hospital | Hagerstown | Maryland | 21740 | — |
| Northern Michigan Hospital | Petoskey | Michigan | 49770 | — |
| Regional Cancer Center at Singing River Hospital | Pascagoula | Mississippi | 39581 | — |
| Kansas City Cancer Centers - South | Kansas City | Missouri | 64131 | — |
| Star Hematology & Oncology | Phillipsburg | New Jersey | 08865 | — |
| Veterans Affairs Medical Center - Buffalo | Buffalo | New York | 14215 | — |
| Falck Cancer Center at Arnot Ogden Medical Center | Elmira | New York | 14905 | — |
| Hudson Valley Hematology-Oncology Associates - Poughkeepsie | Poughkeepsie | New York | 12601 | — |
| Comprehensive Cancer Center at Pardee Hospital | Hendersonville | North Carolina | 28791 | — |
| Boice Willis Clinic, PA | Rocky Mount | North Carolina | 27804 | — |
| Eastern North Carolina Medical Group, PLLC | Rocky Mount | North Carolina | 27804 | — |
| McDowell Cancer Center at Akron General Medical Center | Akron | Ohio | 44302 | — |
| Gabrail Cancer Center - Canton Office | Canton | Ohio | 44718 | — |
| Gabrail Cancer Center - Dover Office | Dover | Ohio | 44622 | — |
| MedCentral - Mansfield Hospital | Mansfield | Ohio | 44903 | — |
| Signal Point Hematology Oncology Incorporated | Middletown | Ohio | 45042 | — |
| Cancer Treatment Centers of America at Southwestern Regional Medical Center | Tulsa | Oklahoma | 74133-4564 | — |
| Pottsville Cancer Clinic | Pottsville | Pennsylvania | 17901 | — |
| Charleston Hematology Oncology Associates, PA | Charleston | South Carolina | 29403 | — |
| Julie and Ben Rogers Cancer Institute at Memorial Hermann Baptist Beaumont Hospital | Beaumont | Texas | 77701 | — |
| Texas Cancer Clinic | San Antonio | Texas | 78240 | — |
| Cancer Outreach Associates - Abingdon | Abingdon | Virginia | 24211 | — |
| Virginia Oncology Care, PC | Richlands | Virginia | 24641 | — |
| Western Washington Oncology, Incorporated, PS at Western Washington Cancer Center | Lacey | Washington | 98503 | — |
| MultiCare Regional Cancer Center at Tacoma General Hospital | Tacoma | Washington | 98405 | — |
| Mary Babb Randolph Cancer Center at West Virginia University Hospitals | Morgantown | West Virginia | 26506-9300 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00343460, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 2, 2026 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00343460 live on ClinicalTrials.gov.