ClinicalTrials.gov record
The COREG And Lisinopril Combination Therapy In Hypertensive Subjects (COSMOS) Trial
ClinicalTrials.gov ID: NCT00347360
Public ClinicalTrials.gov record NCT00347360. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Double-Dummy, Parallel Group, Factorial Design Trial to Assess the Efficacy and Safety of up to Six Weeks Treatment With 20mg, 40mg, or 80mg QD Doses of Carvedilol Controlled Release Formulation (COREG CR) or 10mg, 20mg, or 40mg QD Doses of Lisinopril (Zestril) or a Combination of One of the Doses of Each Medication
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a randomized, double-blind, double-dummy, parallel group trial employing 15 cells of a 4x4 factorial design (no placebo)to compare the hypertensive effects in patients with Stage 1 and Stage 2 hypertension of carvedilol (20, 40 or 80 mg daily) alone, lisinopril (10, 20 or 40 mg daily) alone, and all combinations of the doses.
Study identification
- NCT ID
- NCT00347360
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 654 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2006 (Type not available)
- Primary completion
- Apr 2008 (Actual)
- Completion
- Apr 2008 (Actual)
- Last update posted
- Dec 26, 2016
2006 – 2008
United States locations
- U.S. sites
- 151
- U.S. states
- 36
- U.S. cities
- 134
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| GSK Investigational Site | Anniston | Alabama | 36207 | — |
| GSK Investigational Site | Birmingham | Alabama | 35215 | — |
| GSK Investigational Site | Birmingham | Alabama | 35216 | — |
| GSK Investigational Site | Birmingham | Alabama | 35235 | — |
| GSK Investigational Site | Birmingham | Alabama | 35242 | — |
| GSK Investigational Site | Haleyville | Alabama | 35565 | — |
| GSK Investigational Site | Mobile | Alabama | 36617 | — |
| GSK Investigational Site | Muscle Shoals | Alabama | 35662 | — |
| GSK Investigational Site | Chandler | Arizona | 85225 | — |
| GSK Investigational Site | Gilbert | Arizona | 85296 | — |
| GSK Investigational Site | Glendale | Arizona | 85308 | — |
| GSK Investigational Site | Mesa | Arizona | 85206 | — |
| GSK Investigational Site | Phoenix | Arizona | 85023 | — |
| GSK Investigational Site | Phoenix | Arizona | 85032 | — |
| GSK Investigational Site | Phoenix, Arizona | Arizona | 86106 | — |
| GSK Investigational Site | Scottsdale | Arizona | 85251 | — |
| GSK Investigational Site | Scottsdale | Arizona | 85260 | — |
| GSK Investigational Site | Sun City | Arizona | 85351 | — |
| GSK Investigational Site | Tucson | Arizona | 85712 | — |
| GSK Investigational Site | Tucson | Arizona | 85741 | — |
| GSK Investigational Site | Little Rock | Arkansas | 72204 | — |
| GSK Investigational Site | Searcy | Arkansas | 72143 | — |
| GSK Investigational Site | Beuna Park | California | 90620 | — |
| GSK Investigational Site | Beverly Hills | California | 90211 | — |
| GSK Investigational Site | Burbank | California | 91505 | — |
| GSK Investigational Site | Carlsbad | California | 92008 | — |
| GSK Investigational Site | Fountain Valley | California | 92708 | — |
| GSK Investigational Site | Fresno | California | 93703 | — |
| GSK Investigational Site | Loma Linda | California | 92354 | — |
| GSK Investigational Site | Mission Viejo | California | 92691 | — |
| GSK Investigational Site | Pico Rivera | California | 90660 | — |
| GSK Investigational Site | Rancho Cordova | California | 95670 | — |
| GSK Investigational Site | San Diego | California | 92117 | — |
| GSK Investigational Site | San Diego | California | 92128 | — |
| GSK Investigational Site | Santa Ana | California | 92705 | — |
| GSK Investigational Site | Vista | California | 92084 | — |
| GSK Investigational Site | Walnut Creek | California | 94598 | — |
| GSK Investigational Site | Colorado Springs | Colorado | 80904 | — |
| GSK Investigational Site | Denver | Colorado | 80206 | — |
| GSK Investigational Site | Wilmington | Delaware | 19805 | — |
| GSK Investigational Site | Washington D.C. | District of Columbia | 20017 | — |
| GSK Investigational Site | Coral Gables | Florida | 33134 | — |
| GSK Investigational Site | Hialeah | Florida | 33013 | — |
| GSK Investigational Site | Hollywood | Florida | 33023 | — |
| GSK Investigational Site | Jacksonville | Florida | 32205 | — |
| GSK Investigational Site | Jacksonville Beach | Florida | 32250 | — |
| GSK Investigational Site | Miami | Florida | 33156 | — |
| GSK Investigational Site | Miami | Florida | 33169 | — |
| GSK Investigational Site | Palm Harbor | Florida | 34684 | — |
| GSK Investigational Site | Pembroke Pines | Florida | 33024 | — |
| GSK Investigational Site | Pembroke Pines | Florida | 33027 | — |
| GSK Investigational Site | Sarasota | Florida | 34239 | — |
| GSK Investigational Site | West Palm Beach | Florida | 33409 | — |
| GSK Investigational Site | Gainesville | Georgia | 30501 | — |
| GSK Investigational Site | Marietta | Georgia | 30066 | — |
| GSK Investigational Site | Sandersville | Georgia | 31082 | — |
| GSK Investigational Site | Savannah | Georgia | 31406 | — |
| GSK Investigational Site | Aurora | Illinois | 60504 | — |
| GSK Investigational Site | Chicago | Illinois | 60607 | — |
| GSK Investigational Site | Chicago | Illinois | 60610 | — |
| GSK Investigational Site | Melrose Park | Illinois | 60160 | — |
| GSK Investigational Site | Avon | Indiana | 46123 | — |
| GSK Investigational Site | Bloomington | Indiana | 47102 | — |
| GSK Investigational Site | Fort Wayne | Indiana | 46804 | — |
| GSK Investigational Site | Indianapolis | Indiana | 46250 | — |
| GSK Investigational Site | Ames | Iowa | 50010 | — |
| GSK Investigational Site | Wichita | Kansas | 67205 | — |
| GSK Investigational Site | Slidell | Louisiana | 70458 | — |
| GSK Investigational Site | Springfield | Massachusetts | 01103 | — |
| GSK Investigational Site | Taunton | Massachusetts | 02780. | — |
| GSK Investigational Site | Bingham Farms | Michigan | 48025 | — |
| GSK Investigational Site | Brooklyn Center | Minnesota | 55430 | — |
| GSK Investigational Site | Missoula | Montana | 59808 | — |
| GSK Investigational Site | O Fallon | Montana | 63366 | — |
| GSK Investigational Site | Omaha | Nebraska | 68131 | — |
| GSK Investigational Site | Las Vegas | Nevada | 89016 | — |
| GSK Investigational Site | Las Vegas | Nevada | 89119 | — |
| GSK Investigational Site | Las Vegas | Nevada | 89128 | — |
| GSK Investigational Site | Cherry Hill | New Jersey | 08034 | — |
| GSK Investigational Site | Edison | New Jersey | 08817 | — |
| GSK Investigational Site | Ridgewood | New Jersey | 7450 | — |
| GSK Investigational Site | Voorhees Township | New Jersey | 08043 | — |
| GSK Investigational Site | Albuquerque | New Mexico | 87102 | — |
| GSK Investigational Site | Brooklyn | New York | 11203 | — |
| GSK Investigational Site | Buffalo | New York | 14215 | — |
| GSK Investigational Site | Kingston | New York | 12401 | — |
| GSK Investigational Site | Lewinston | New York | 14092 | — |
| GSK Investigational Site | Tonawanda | New York | 14150-1810 | — |
| GSK Investigational Site | Asheville | North Carolina | 28801 | — |
| GSK Investigational Site | Charlotte | North Carolina | 28211 | — |
| GSK Investigational Site | High Point | North Carolina | 27262 | — |
| GSK Investigational Site | Raleigh | North Carolina | 27615 | — |
| GSK Investigational Site | Fargo | North Dakota | 58103 | — |
| GSK Investigational Site | Cincinnati | Ohio | 45219 | — |
| GSK Investigational Site | Cincinnati | Ohio | 45236 | — |
| GSK Investigational Site | Cleveland | Ohio | 44106 | — |
| GSK Investigational Site | Cleveland | Ohio | 44195 | — |
| GSK Investigational Site | Dayton | Ohio | 45406 | — |
| GSK Investigational Site | Oklahoma City | Oklahoma | 73103 | — |
| GSK Investigational Site | Oklahoma City | Oklahoma | 73112 | — |
| GSK Investigational Site | Tulsa | Oklahoma | 74104 | — |
| GSK Investigational Site | Eugene | Oregon | 97401 | — |
| GSK Investigational Site | Beaver | Pennsylvania | 15009 | — |
| GSK Investigational Site | Doylestown | Pennsylvania | 18901 | — |
| GSK Investigational Site | Erie | Pennsylvania | 16504 | — |
| GSK Investigational Site | Havertown | Pennsylvania | 19083 | — |
| GSK Investigational Site | Landsdale | Pennsylvania | 19446 | — |
| GSK Investigational Site | Leetsdale | Pennsylvania | 15056 | — |
| GSK Investigational Site | Philadelphia | Pennsylvania | 19152 | — |
| GSK Investigational Site | Philadelphia | Pennsylvania | 19154 | — |
| GSK Investigational Site | Warminster | Pennsylvania | 18974 | — |
| GSK Investigational Site | West Chester | Pennsylvania | 19380 | — |
| GSK Investigational Site | Beaufort | South Carolina | 29906 | — |
| GSK Investigational Site | Charleston | South Carolina | 29403 | — |
| GSK Investigational Site | Columbia | South Carolina | 29201 | — |
| GSK Investigational Site | Gaffney | South Carolina | 29340 | — |
| GSK Investigational Site | Greer | South Carolina | 29651 | — |
| GSK Investigational Site | Hilton Head Island | South Carolina | 29926 | — |
| GSK Investigational Site | Manning | South Carolina | 29102 | — |
| GSK Investigational Site | Simpsonville | South Carolina | 29681 | — |
| GSK Investigational Site | Spartanburg | South Carolina | 29303 | — |
| GSK Investigational Site | Sumter | South Carolina | 29150 | — |
| GSK Investigational Site | Taylors | South Carolina | 29687 | — |
| GSK Investigational Site | Union | South Carolina | 29309 | — |
| GSK Investigational Site | Clarksville | Tennessee | 37043 | — |
| GSK Investigational Site | Jackson | Tennessee | 38305 | — |
| GSK Investigational Site | Johnson City | Tennessee | 37601 | — |
| GSK Investigational Site | Nashville | Tennessee | 37203 | — |
| GSK Investigational Site | Selmer | Tennessee | 38375 | — |
| GSK Investigational Site | Arlington | Texas | 76014 | — |
| GSK Investigational Site | Austin | Texas | 78705 | — |
| GSK Investigational Site | Georgetown | Texas | 78626 | — |
| GSK Investigational Site | Grand Prairie/Texas | Texas | 5052 | — |
| GSK Investigational Site | Houston | Texas | 77081 | — |
| GSK Investigational Site | Longview | Texas | 75605 | — |
| GSK Investigational Site | San Antonio | Texas | 78224 | — |
| GSK Investigational Site | San Antonio | Texas | 78229 | — |
| GSK Investigational Site | Sugar Land | Texas | 77479 | — |
| GSK Investigational Site | Temple | Texas | 76502 | — |
| GSK Investigational Site | Waco | Texas | 76712 | — |
| GSK Investigational Site | Murray | Utah | 84107 | — |
| GSK Investigational Site | Salt Lake City | Utah | 84102 | — |
| GSK Investigational Site | Sandy City | Utah | 84094 | — |
| GSK Investigational Site | Arlington | Virginia | 22205 | — |
| GSK Investigational Site | Burke | Virginia | 22015 | — |
| GSK Investigational Site | Chester | Virginia | 23836 | — |
| GSK Investigational Site | Fairfax | Virginia | 22030 | — |
| GSK Investigational Site | Manassas | Virginia | 20110 | — |
| GSK Investigational Site | Spokane | Washington | 99206 | — |
| GSK Investigational Site | Tacoma | Washington | 98405 | — |
| GSK Investigational Site | Milwaukee | Wisconsin | 53209 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00347360, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 26, 2016 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00347360 live on ClinicalTrials.gov.