ClinicalTrials.gov record
Effectiveness of Pacemaker With Closed Loop Stimulation Compared to Pacemakers With and Without Standard Rate Response
ClinicalTrials.gov ID: NCT00355797
Public ClinicalTrials.gov record NCT00355797. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
CLEAR: Cylos Pacemaker Responds With Physiologic Rate Changes During Daily Activities
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a randomized, prospective, single-blinded, multi-center study involving approximately 1500 patients at 100 centers. The purpose of this study is to demonstrate the effectiveness of Closed Loop Stimulation (CLS) rate adaption technology over both standard rate responsive technology (R) and non-rate responsive mode (DDD) during activities of daily living (ADL).
Study identification
- NCT ID
- NCT00355797
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 1,491 participants
Conditions and interventions
Conditions
Interventions
- Closed Loop Stimulation (CLS) Device
- Standard Rate Adaptive (R) Technology Device
- Non-rate adaptive (DDD) pacing Device
Device
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 30, 2006
- Primary completion
- Jan 31, 2008
- Completion
- Nov 30, 2010
- Last update posted
- Dec 19, 2012
2006 – 2010
United States locations
- U.S. sites
- 99
- U.S. states
- 29
- U.S. cities
- 85
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Raymond Fernandez | Albertville | Alabama | 35951 | — |
| Cardiology Associates-Gadsden | Gadsden | Alabama | 35901 | — |
| North Alabama Cardiology Center | Gadsden | Alabama | 35901 | — |
| Richard Kim, MD | Jasper | Alabama | 35501 | — |
| Arizona Heart Institute | Phoenix | Arizona | 85006 | — |
| N.R. Devaraj, M.D., Inc. | Anaheim | California | 92804 | — |
| Family Doctor Medical Group | Benicia | California | 94510 | — |
| Caremore Medical Group | Downey | California | 90240 | — |
| Multani Medical Group | Downey | California | 90241 | — |
| Solano Cardiology | Fairfield | California | 94533 | — |
| Pacific Cardiology Associates | Fremont | California | 94538 | — |
| San Joaquin General Hospital | French Camp | California | 95231 | — |
| Kenny Charn, MD | Jackson | California | 95642 | — |
| Kartik Thaker, MD | Lakewood | California | 90712 | — |
| Mission Internal Medical Group | Mission Viejo | California | 92691 | — |
| Cardio-Pulmonary Associates | Monterey | California | 93940 | — |
| St. Luke Cardiovascular Medical Group | Murrieta | California | 92562 | — |
| Sacramento Heart & Vascular | Sacramento | California | 95825 | — |
| Emad Khaleeli, MD | Torrance | California | 90503 | — |
| Torrance Memorial Medical Center | Torrance | California | 90505 | — |
| Cardiology Consultants | Turlock | California | 95382 | — |
| Ventura Cardiology | Ventura | California | 93003 | — |
| Alireza Jafari, MD | Whittier | California | 90603 | — |
| Colorado Cardiovascular Center | Boulder | Colorado | 80301 | — |
| Boulder Medical Center | Boulder | Colorado | 80304 | — |
| Western Cardiology Associates | Denver | Colorado | 80210 | — |
| Aurora Denver Cardiology Associates | Denver | Colorado | 80218 | — |
| Western Cardiology Associates | Englewood | Colorado | 80113 | — |
| Alfieri Cardiology | Newark | Delaware | 19713 | — |
| Southern Heart Group | Jacksonville | Florida | 32207 | — |
| Melbourne Internal Medicine Associates | Melbourne | Florida | 32901 | — |
| Complete Cardiology Care | New Smyrna Beach | Florida | 32168 | — |
| Cardiology Consultants, PA | Pensacola | Florida | 32504 | — |
| Space Coast Cardiology Consultants | Port Saint John | Florida | 32927 | — |
| Brevard Cardiovascular Research Association | Rockledge | Florida | 32955 | — |
| Northside Cardiology, PC | Atlanta | Georgia | 30342 | — |
| Doris Tummillo, MD | Augusta | Georgia | 30904 | — |
| Collins Cardiology | Douglas | Georgia | 31533 | — |
| Douglas Medical Specialists | Douglas | Georgia | 31533 | — |
| St. Louis Cardiology Consultants - Alton | Alton | Illinois | 62002 | — |
| Naeem Khan, MD | Centralia | Illinois | 62801 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Amr El-Shafei, MD | Mount Vernon | Illinois | 62864 | — |
| Bluegrass Cardiology | Louisville | Kentucky | 40215 | — |
| Tulane University Medical Center | New Orleans | Louisiana | 70112 | — |
| Ochsner Clinic | New Orleans | Louisiana | 70121 | — |
| New England Cardiovascular Specialists | Boston | Massachusetts | 02135 | — |
| West Michigan Cardiology | Grand Rapids | Michigan | 49525 | — |
| Thorasic and Cardiovascular Institute | Lansing | Michigan | 48910 | — |
| Minneapolis VA | Minneapolis | Minnesota | 55417 | — |
| Pidikiti Cardiology | Corinth | Mississippi | 38834 | — |
| Coast Heart Institute | Gulfport | Mississippi | 39501 | — |
| Midwest Health Professionals, P.C. | Bridgeton | Missouri | 63044 | — |
| Cardiac Specialists of St. Lukes | Crystal City | Missouri | 63019 | — |
| Chand Medical Office | Farmington | Missouri | 63640 | — |
| Manzoor Tariq, MD | Festus | Missouri | 63028 | — |
| Liberty Cardiovascular Specialists | Liberty | Missouri | 64068 | — |
| Heartland Medical Associates, LLC | Moberly | Missouri | 65270 | — |
| Lake Cardiovascular Institute, P.C. | Osage Beach | Missouri | 65065 | — |
| Zia Ahmad, MD, FACC | St Louis | Missouri | 63122 | — |
| Gateway Cardiology, PC | St Louis | Missouri | 63128 | — |
| St. Louis Cardiology Center, P.C. | St Louis | Missouri | 63131 | — |
| St. Louis Cardiovascular Center | St Louis | Missouri | 63131 | — |
| Lalit Chouhan, MD | St Louis | Missouri | 63136 | — |
| St. Louis Heart and Vascular, P.C. | St Louis | Missouri | 63136 | — |
| Abbas Shehadeh, MD, FACC | West Orange | New Jersey | 07052 | — |
| White Sands Institute for Clinical Research | Las Cruces | New Mexico | 88011 | — |
| Ohri Medical Group, P.C. | Warsaw | New York | 14569 | — |
| Heart Group of the Carolinas | Concord | North Carolina | 28025 | — |
| Carolina Heart Care | Elkin | North Carolina | 28621 | — |
| Carolina Heart Specialists | Gastonia | North Carolina | 28054 | — |
| Piedmont Cardiology | Hickory | North Carolina | 28602 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| Westside Cardiology Associates, Inc. | Fairview Park | Ohio | 44126 | — |
| Toledo Clinic Cardiology | Toledo | Ohio | 43623 | — |
| Oklahoma Heart Institute | Tulsa | Oklahoma | 74104 | — |
| Bryan Lucenta, MD | Tulsa | Oklahoma | 74136 | — |
| Lakshmi Mizin, M.D. | Carbondale | Pennsylvania | 18407 | — |
| Alderfer & Travis Associates | Sellersville | Pennsylvania | 18960 | — |
| Carolina Heart and Vascular Center | Aiken | South Carolina | 29801 | — |
| Charleston Cardiology | Charleston | South Carolina | 29403 | — |
| South Carolina Heart Center | Columbia | South Carolina | 29204 | — |
| Pee Dee Cardiology | Florence | South Carolina | 29505 | — |
| Carolina Heart Specialists | Lancaster | South Carolina | 29720 | — |
| Carolina Cardiology Associates | Rock Hill | South Carolina | 29732 | — |
| Heart Rhythm Specialists of East Tennessee | Knoxville | Tennessee | 37923 | — |
| Lone Star Arrhythmia and Heart Failure Center | Amarillo | Texas | 79106 | — |
| Austin Cardiac Clinic | Austin | Texas | 78705 | — |
| Fort Worth Heart | Burleson | Texas | 76028 | — |
| Dallas VA Medical Center | Dallas | Texas | 75216 | — |
| Cardiology Care Consultants | El Paso | Texas | 79902 | — |
| Fort Worth Heart | Fort Worth | Texas | 76104 | — |
| Cardiology Associates of West Texas | San Angelo | Texas | 76904 | — |
| Cardiac Electrophysiology Consultants of S. Texas | San Antonio | Texas | 78229 | — |
| Wasatch Cardiology Consultants, PC | Salt Lake City | Utah | 84123 | — |
| Cardiovascular Associates of Virginia | Richmond | Virginia | 23225 | — |
| McGuire VA Medical Center | Richmond | Virginia | 23249 | — |
| Daniel Gottlieb | Burien | Washington | 98166 | — |
| Waukesha Heart Institute | Waukesha | Wisconsin | 53188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00355797, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 19, 2012 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00355797 live on ClinicalTrials.gov.