Diabetes Control and Complications Trial (DCCT)
Public ClinicalTrials.gov record NCT00360815. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Background. Long-term microvascular and neurologic complications cause major morbidity and mortality in patients with insulin-dependent diabetes mellitus (IDDM). We examined whether intensive treatment with the goal of maintaining blood glucose concentrations close to the normal range could decrease the frequency and severity of these complications. Methods. A total of 1441 patients with IDDM -- 726 with no retinopathy at base line (the primary-prevention cohort) and 715 with mild retinopathy (the secondary-intervention cohort) were randomly assigned to intensive therapy administered either with an external insulin pump or by three or more daily insulin injections and guided by frequent blood glucose monitoring or to conventional therapy with one or two daily insulin injections. The patients were followed for a mean of 6.5 years, and the appearance and progression of retinopathy and other complications were assessed regularly.
Study identification
- NCT ID
- NCT00360815
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 1,441 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 13 Years to 39 Years
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 1983 (Type not available)
- Primary completion
- Not listed
- Completion
- Apr 1993 (Type not available)
- Last update posted
- Mar 2, 2010
1983 – 1993
United States locations
- U.S. sites
- 35
- U.S. states
- 19
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of California | La Jolla | California | 92093-0620 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06510 | — |
| University of South Florida College of Medicine | Tampa | Florida | 33612 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| DCCT Central Autonomic Coding Unit | Springfield | Illinois | 62702 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| University of Maryland | Baltimore | Maryland | 21201 | — |
| George Washington University, Biostatistics Center | Rockville | Maryland | 20852 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Joslin Diabetes Center, Inc. | Boston | Massachusetts | 02215 | — |
| University of Michigan, Sattelite-Henry Ford Hospital | Ann Arbor | Michigan | 48109-0832 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| International Diabetes Center | Minneapolis | Minnesota | 55416 | — |
| DCCT Central Nutrition Coding Unit | Minneapolis | Minnesota | 55454-1015 | — |
| DCCT Central ECG Reading Unit | Minneapolis | Minnesota | 55455-1015 | — |
| DCCT Central Biochemistry Laboratory | Minneapolis | Minnesota | 55455-9980 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Mayo Foundation | Rochester | Minnesota | 55905 | — |
| Backup DCCT Central HbA1c Lab | Columbia | Missouri | 65201 | — |
| University of Missouri | Columbia | Missouri | 65212 | — |
| Washington University at St. Louis | St Louis | Missouri | 63110 | — |
| University of New Mexico School of Medicine | Albuquerque | New Mexico | 87131 | — |
| Cornell University Medical College, The New York Hospital | New York | New York | 10021 | — |
| Albert Einstein College of Medicine | The Bronx | New York | 10461 | — |
| Case Western Reserve University, Lakeside Hospital | Cleveland | Ohio | 44106 | — |
| University of Pennsylvania, The Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh, Children's Hospital | Pittsburgh | Pennsylvania | 15213-3417 | — |
| DCCT Central Neurobehavioral Coding Unit | Pittsburgh | Pennsylvania | 15213 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29403-5851 | — |
| University of Tennessee | Memphis | Tennessee | 38163 | — |
| Vanderbilt University, Diabetes Research and Training Center | Nashville | Tennessee | 37212 | — |
| Vanderbilt University | Nashville | Tennessee | 37232-2230 | — |
| University of Texas | Dallas | Texas | 75235 | — |
| University of Washington | Seattle | Washington | 98195 | — |
| DCCT Central Ophthalmologic Reading Unit, Fundus Photo Reading Center | Madison | Wisconsin | 53705-0240 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00360815, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 2, 2010 · Synced Sep 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00360815 live on ClinicalTrials.gov.