ClinicalTrials.gov record
Zoledronate, Vitamin D, and Calcium With or Without Strontium 89 or Samarium 153 in Preventing or Delaying Bone Problems in Patients With Bone Metastases From Prostate Cancer, Lung Cancer, or Breast Cancer
ClinicalTrials.gov ID: NCT00365105
Public ClinicalTrials.gov record NCT00365105. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Phase III Trial to Evaluate Radiopharmaceuticals and Zoledronic Acid in the Palliation of Osteoblastic Metastases From Lung, Breast, and Prostate Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Zoledronate, vitamin D and calcium may prevent or delay bone pain and other symptoms caused by bone metastases. It is not yet known whether giving zoledronate together with vitamin D and calcium is more effective with or without strontium 89 or samarium 153 in treating patients with bone metastases from prostate cancer, lung cancer, or breast cancer. PURPOSE: This randomized phase III trial is studying zoledronate, vitamin D, and calcium to see how well they work compared to zoledronate, vitamin D, calcium, and either strontium 89 or samarium 153 in preventing or delaying bone problems in patients with bone metastases from prostate cancer, lung cancer, or breast cancer.
Study identification
- NCT ID
- NCT00365105
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 261 participants
Conditions and interventions
Conditions
Interventions
- Calcium Dietary Supplement
- Vitamin D Dietary Supplement
- zoledronic acid Drug
- Sm-153 Drug
- Sr-89 Radiation
Dietary Supplement · Drug · Radiation
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 10, 2006
- Primary completion
- Dec 31, 2011
- Completion
- Feb 26, 2017
- Last update posted
- Sep 19, 2024
2006 – 2017
United States locations
- U.S. sites
- 147
- U.S. states
- 32
- U.S. cities
- 119
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Providence Cancer Center at Providence Hospital | Mobile | Alabama | 36608 | — |
| Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center | Burbank | California | 91505 | — |
| Mercy Cancer Center at Mercy San Juan Medical Center | Carmichael | California | 95608 | — |
| USC/Norris Comprehensive Cancer Center and Hospital | Los Angeles | California | 90089-9181 | — |
| Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center | Pomona | California | 91767 | — |
| Radiation Oncology Center - Roseville | Roseville | California | 95661 | — |
| Radiological Associates of Sacramento Medical Group, Incorporated | Sacramento | California | 95815 | — |
| General Robert Huyser Cancer Center at David Grant Medical Center | Travis Air Force Base | California | 94535-1800 | — |
| Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | — |
| Baptist Cancer Institute - Jacksonville | Jacksonville | Florida | 32207 | — |
| Integrated Community Oncology Network at Southside Cancer Center | Jacksonville | Florida | 32207 | — |
| Baptist Medical Center South | Jacksonville | Florida | 32258 | — |
| Integrated Community Oncology Network | Jacksonville Beach | Florida | 32250 | — |
| Miami Cancer Center at Mercy Hospital | Miami | Florida | 33133 | — |
| CCOP - Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| Integrated Community Oncology Network - Orange Park | Orange Park | Florida | 32073 | — |
| Florida Cancer Center - Palatka | Palatka | Florida | 32177 | — |
| Bay Medical | Panama City | Florida | 32401 | — |
| Flagler Cancer Center | Saint Augustine | Florida | 32086 | — |
| H. Lee Moffitt Cancer Center and Research Institute at University of South Florida | Tampa | Florida | 33612-9497 | — |
| John B. Amos Cancer Center | Columbus | Georgia | 31904 | — |
| Northeast Georgia Medical Center | Gainesville | Georgia | 30501 | — |
| Northwest Community Hospital | Arlington Heights | Illinois | 60005 | — |
| Good Samaritan Cancer Care Center at Advocate Good Samaritan Hospital | Downers Grove | Illinois | 60515-1500 | — |
| Ingalls Cancer Care Center at Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| Veterans Affairs Medical Center - Hines | Hines | Illinois | 60141 | — |
| Advocate Christ Medical Center | Oak Lawn | Illinois | 60453-2699 | — |
| Advocate Lutheran General Cancer Care Center | Park Ridge | Illinois | 60068-1174 | — |
| Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria | Illinois | 61615 | — |
| Cancer Institute at St. John's Hospital | Springfield | Illinois | 62702 | — |
| CCOP - Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Center for Cancer Care at Goshen General Hospital | Goshen | Indiana | 46526 | — |
| Cancer Center at Ball Memorial Hospital | Muncie | Indiana | 47303-3499 | — |
| CCOP - Northern Indiana CR Consortium | South Bend | Indiana | 46601 | — |
| McFarland Clinic, PC | Ames | Iowa | 50010 | — |
| CCOP - Iowa Oncology Research Association | Des Moines | Iowa | 50309 | — |
| John Stoddard Cancer Center at Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| Medical Oncology and Hematology Associates at John Stoddard Cancer Center | Des Moines | Iowa | 50309 | — |
| Medical Oncology and Hematology Associates at Mercy Cancer Center | Des Moines | Iowa | 50314 | — |
| Mercy Cancer Center at Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | — |
| Siouxland Hematology-Oncology Associates, LLP | Sioux City | Iowa | 51101 | — |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | — |
| CCOP - Wichita | Wichita | Kansas | 67214 | — |
| Central Baptist Hospital | Lexington | Kentucky | 40503-9985 | — |
| Tulane Cancer Center Office of Clinical Research | Alexandria | Louisiana | 71315-3198 | — |
| Central Maine Comprehensive Cancer Center at Central Maine Medical Center | Lewiston | Maine | 04240 | — |
| St. Agnes Hospital Cancer Center | Baltimore | Maryland | 21229 | — |
| Hudner Oncology Center at Saint Anne's Hospital - Fall River | Fall River | Massachusetts | 02721 | — |
| Cape Cod Hospital | Hyannis | Massachusetts | 02601 | — |
| Saint Joseph Mercy Cancer Center | Ann Arbor | Michigan | 48106-0995 | — |
| Oakwood Cancer Center at Oakwood Hospital and Medical Center | Dearborn | Michigan | 48123-2500 | — |
| Josephine Ford Cancer Center at Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods | Michigan | 48236 | — |
| Dickinson County Healthcare System | Iron Mountain | Michigan | 49801 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007-3731 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| Sparrow Regional Cancer Center | Lansing | Michigan | 48912-1811 | — |
| St. John Macomb Hospital | Warren | Michigan | 48093 | — |
| CentraCare Clinic - River Campus | Saint Cloud | Minnesota | 56303 | — |
| Regional Cancer Center at Singing River Hospital | Pascagoula | Mississippi | 39581 | — |
| Truman Medical Center - Hospital Hill | Kansas City | Missouri | 64108 | — |
| CCOP - Kansas City | Kansas City | Missouri | 64131 | — |
| St. John's Regional Health Center | Springfield | Missouri | 65804 | — |
| Hulston Cancer Center at Cox Medical Center South | Springfield | Missouri | 65807 | — |
| CCOP - Montana Cancer Consortium | Billings | Montana | 59101 | — |
| Northern Rockies Radiation Oncology Center | Billings | Montana | 59101 | — |
| Billings Clinic - Downtown | Billings | Montana | 59107-7000 | — |
| Great Falls Clinic - Main Facility | Great Falls | Montana | 59405 | — |
| Good Samaritan Cancer Center at Good Samaritan Hospital | Kearney | Nebraska | 68848-1990 | — |
| Princeton Radiation Oncology Center | Jamesburg | New Jersey | 08831 | — |
| Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton | Marlton | New Jersey | 08053 | — |
| University Medical Center at Princeton | Princeton | New Jersey | 08540-3298 | — |
| Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare | Vineland | New Jersey | 08360 | — |
| Cancer Institute of New Jersey at Cooper - Voorhees | Voorhees Township | New Jersey | 08043 | — |
| New Mexico Cancer Center | Albuquerque | New Mexico | 87109 | — |
| New York Methodist Hospital | Brooklyn | New York | 11215 | — |
| Sands Cancer Center | Canandaigua | New York | 14424 | — |
| Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center | Plattsburgh | New York | 12901 | — |
| Highland Hospital of Rochester | Rochester | New York | 14620 | — |
| Lipson Cancer and Blood Center at Rochester General Hospital | Rochester | New York | 14621 | — |
| University Radiation Oncology at Parkridge Hospital | Rochester | New York | 14626 | — |
| James P. Wilmot Cancer Center at University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Mission Hospitals - Memorial Campus | Asheville | North Carolina | 28801 | — |
| Presbyterian Cancer Center at Presbyterian Hospital | Charlotte | North Carolina | 28233-3549 | — |
| Wayne Radiation Oncology | Goldsboro | North Carolina | 27534 | — |
| Trinity CancerCare Center | Minot | North Dakota | 58701 | — |
| McDowell Cancer Center at Akron General Medical Center | Akron | Ohio | 44307 | — |
| Summa Center for Cancer Care at Akron City Hospital | Akron | Ohio | 44309-2090 | — |
| Radiation Oncology Center | Alliance | Ohio | 44601 | — |
| Barberton Citizens Hospital | Barberton | Ohio | 44203 | — |
| Mercy Cancer Center at Mercy Medical Center | Canton | Ohio | 44708 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| CCOP - Columbus | Columbus | Ohio | 43215 | — |
| Grandview Hospital | Dayton | Ohio | 45405 | — |
| Good Samaritan Hospital | Dayton | Ohio | 45406 | — |
| David L. Rike Cancer Center at Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Samaritan North Cancer Care Center | Dayton | Ohio | 45415 | — |
| CCOP - Dayton | Dayton | Ohio | 45420 | — |
| Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Charles F. Kettering Memorial Hospital | Kettering | Ohio | 45429 | — |
| MedCentral - Mansfield Hospital | Mansfield | Ohio | 44903 | — |
| Cancer Care Center, Incorporated | Salem | Ohio | 44460 | — |
| UVMC Cancer Care Center at Upper Valley Medical Center | Troy | Ohio | 45373-1300 | — |
| Cancer Treatment Center | Wooster | Ohio | 44691 | — |
| United States Air Force Medical Center - Wright-Patterson | Wright-Patterson Air Force Base | Ohio | 45433-5529 | — |
| Ruth G. McMillan Cancer Center at Greene Memorial Hospital | Xenia | Ohio | 45385 | — |
| Natalie Warren Bryant Cancer Center at St. Francis Hospital | Tulsa | Oklahoma | 74136 | — |
| Rosenfeld Cancer Center at Abington Memorial Hospital | Abington | Pennsylvania | 19001 | — |
| UPMC Cancer Center at Beaver Medical Center | Beaver | Pennsylvania | 15009 | — |
| UPMC Cancer Center at Jefferson Regional Medical Center | Clairton | Pennsylvania | 15025 | — |
| Northeast Radiation Oncology Center | Dunmore | Pennsylvania | 18512 | — |
| UPMC Cancer Center - Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | — |
| UPMC Cancer Center at the John P. Murtha Pavilion | Johnstown | Pennsylvania | 15901 | — |
| UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania | 15132 | — |
| UPMC - Moon | Moon Township | Pennsylvania | 15108 | — |
| UPMC Cancer Center - Natrona Heights | Natrona Heights | Pennsylvania | 15065 | — |
| Jameson Memorial Hospital - North Campus | New Castle | Pennsylvania | 16105 | — |
| UPMC - Shadyside | Pittsburgh | Pennsylvania | 15213-2582 | — |
| UPMC Cancer Center at Magee-Womens Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC Cancer Center at UPMC Presbyterian | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC Cancer Center at UPMC St. Margaret | Pittsburgh | Pennsylvania | 15215 | — |
| UPMC Cancer Center at UPMC Passavant | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC Cancer Center - Upper St. Clair | Pittsburgh | Pennsylvania | 15243 | — |
| UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | 16346 | — |
| Mount Nittany Medical Center | State College | Pennsylvania | 16803 | — |
| UPMC Cancer Center - Uniontown | Uniontown | Pennsylvania | 15401 | — |
| Washington Hospital Cancer Center | Washington | Pennsylvania | 15301 | — |
| York Cancer Center at Apple Hill Medical Center | York | Pennsylvania | 17405 | — |
| Hollings Cancer Center at Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| CCOP - Greenville | Greenville | South Carolina | 29615 | — |
| Jon and Karen Huntsman Cancer Center at Intermountain Medical Center | Murray | Utah | 84157 | — |
| Utah Cancer Specialists at UCS Cancer Center | Salt Lake City | Utah | 84106 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Dixie Regional Medical Center - East Campus | St. George | Utah | 84770 | — |
| St. Francis Hospital | Federal Way | Washington | 98003 | — |
| Good Samaritan Cancer Center | Puyallup | Washington | 98372 | — |
| CCOP - Virginia Mason Research Center | Seattle | Washington | 98101 | — |
| Franciscan Cancer Center at St. Joseph Medical Center | Tacoma | Washington | 98405-3004 | — |
| CCOP - Northwest | Tacoma | Washington | 98405 | — |
| MultiCare Regional Cancer Center at Tacoma General Hospital | Tacoma | Washington | 98405 | — |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | 98902 | — |
| Theda Care Cancer Institute | Appleton | Wisconsin | 54911 | — |
| Bellin Memorial Hospital | Green Bay | Wisconsin | 54301 | — |
| Riverview UW Cancer Center at Riverview Hospital | Wisconsin Rapids | Wisconsin | 54494 | — |
| Welch Cancer Center at Sheridan Memorial Hospital | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00365105, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 19, 2024 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00365105 live on ClinicalTrials.gov.