Safety and Efficacy Study of Ambrisentan in Subjects With Pulmonary Hypertension
Public ClinicalTrials.gov record NCT00380068. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
ARIES-3: A Phase 3, Long-Term, Open-Label, Multicenter Safety and Efficacy Study of Ambrisentan in Subjects With Pulmonary Hypertension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study was to evaluate the safety and efficacy of ambrisentan in a broad population of participants with pulmonary hypertension (PH). Secondary objectives of this study were to evaluate the effects of ambrisentan on other clinical measures of pulmonary arterial hypertension (PAH), long-term treatment success, and survival.
Study identification
- NCT ID
- NCT00380068
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 224 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 2006 (Type not available)
- Primary completion
- Jul 2008 (Actual)
- Completion
- May 2009 (Actual)
- Last update posted
- Apr 5, 2012
2006 – 2009
United States locations
- U.S. sites
- 34
- U.S. states
- 23
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Arizona Pulmonary Specialists, Ltd | Phoenix | Arizona | 85013 | — |
| UCSD Medical Center, Thornton Hospital | La Jolla | California | 92037 | — |
| Greater Los Angeles, VA Medical Center | Los Angeles | California | 90073 | — |
| Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| University of Colorado Health Sciences Center | Aurora | Colorado | 80045 | — |
| University of Connecticut Health Center | Farmington | Connecticut | 06030 | — |
| Pulmonary Hypertension Clinic Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| Suncoast Lung Center | Sarasota | Florida | 34233 | — |
| Medical College of Georgia | Augusta | Georgia | 30912 | — |
| Atlanta Institute for Medical Research, Inc. | Decatur | Georgia | 30030 | — |
| University of Chicago Hospitals | Chicago | Illinois | 60637 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| Tufts-New England Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Boston Adult Congenital Heart Service | Boston | Massachusetts | 02115 | — |
| Boston University School of Medicine | Boston | Massachusetts | 02118 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| University of Medicine & Dentistry of New Jersey | Newark | New Jersey | 07103 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| New York Presbyterian Pulmonary Hypertension Center | New York | New York | 10032 | — |
| Mary Parkes Asthma Center | Rochester | New York | 14623 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| The Lindner Clinical Trial Center | Cincinnati | Ohio | 45219 | — |
| University Hospitals of Cleveland | Cleveland | Ohio | 44106 | — |
| Legacy Clinical Northwest | Portland | Oregon | 97210 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| University of Pittsburgh Medical Center Presbyterian | Pittsburgh | Pennsylvania | 15213 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Lexington Pulmonary and Critical Care | Lexington | South Carolina | 29072 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| University of Virginia Health Sciences Center | Charlottesville | Virginia | 22908 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00380068, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 5, 2012 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00380068 live on ClinicalTrials.gov.