ClinicalTrials.gov record
Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia
ClinicalTrials.gov ID: NCT00381680
Public ClinicalTrials.gov record NCT00381680. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Intensive Treatment for Intermediate-Risk Relapse of Childhood B-precursor Acute Lymphoblastic Leukemia (ALL): A Randomized Trial of Vincristine Strategies
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase III trial is studying low-dose vincristine to see how well it works compared with high-dose vincristine when given together with different combination chemotherapy regimens in treating young patients with intermediate-risk relapsed B-cell acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) and giving the drugs in different ways and different doses may kill more cancer cells..
Study identification
- NCT ID
- NCT00381680
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 275 participants
Conditions and interventions
Conditions
Interventions
- vincristine sulfate Drug
- prednisone Drug
- doxorubicin hydrochloride Drug
- pegaspargase Drug
- cytarabine Drug
- methotrexate Drug
- dexamethasone Drug
- etoposide Drug
- cyclophosphamide Drug
- leucovorin calcium Drug
- filgrastim Biological
- asparaginase Drug
- mercaptopurine Drug
Drug · Biological
Eligibility (public fields only)
- Age range
- 1 Year to 29 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 28, 2007
- Primary completion
- Feb 29, 2016
- Completion
- Not listed
- Last update posted
- Mar 25, 2024
Started 2007
United States locations
- U.S. sites
- 159
- U.S. states
- 45
- U.S. cities
- 129
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Children's Hospital of Alabama | Birmingham | Alabama | 35233 | — |
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Phoenix Childrens Hospital | Phoenix | Arizona | 85016 | — |
| University of Arizona Health Sciences Center | Tucson | Arizona | 85724 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Children's Oncology Group | Arcadia | California | 91006-3776 | — |
| Southern California Permanente Medical Group | Downey | California | 90242 | — |
| City of Hope Medical Center | Duarte | California | 91010 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| Miller Children's Hospital | Long Beach | California | 90806 | — |
| Children's Hospital Los Angeles | Los Angeles | California | 90027 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Children's Hospital Central California | Madera | California | 93636-8762 | — |
| Children's Hospital and Research Center at Oakland | Oakland | California | 94609-1809 | — |
| Kaiser Permanente-Oakland | Oakland | California | 94611 | — |
| Childrens Hospital of Orange County | Orange | California | 92868-3874 | — |
| Lucile Packard Children's Hospital Stanford University | Palo Alto | California | 94304 | — |
| Sutter General Hospital | Sacramento | California | 95816 | — |
| UC Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| Rady Children's Hospital - San Diego | San Diego | California | 92123 | — |
| University of California San Francisco Medical Center-Parnassus | San Francisco | California | 94143 | — |
| Santa Barbara Cottage Hospital | Santa Barbara | California | 93102 | — |
| Children's Hospital Colorado | Aurora | Colorado | 80045 | — |
| Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center | Denver | Colorado | 80218 | — |
| Connecticut Children's Medical Center | Hartford | Connecticut | 06106 | — |
| Yale University | New Haven | Connecticut | 06520-8032 | — |
| Alfred I duPont Hospital for Children | Wilmington | Delaware | 19803 | — |
| Children's National Medical Center | Washington D.C. | District of Columbia | 20010 | — |
| Lombardi Comprehensive Cancer Center at Georgetown University | Washington D.C. | District of Columbia | 20057 | — |
| Broward Health Medical Center | Fort Lauderdale | Florida | 33316 | — |
| Lee Memorial Health System | Fort Myers | Florida | 33901 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Nemours Children's Clinic - Jacksonville | Jacksonville | Florida | 32207-8426 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Miami Children's Hospital | Miami | Florida | 33155 | — |
| Baptist Hospital of Miami | Miami | Florida | 33176 | — |
| Florida Hospital | Orlando | Florida | 32803 | — |
| M D Anderson Cancer Center- Orlando | Orlando | Florida | 32806 | — |
| Nemours Childrens Clinic - Orlando | Orlando | Florida | 32806 | — |
| Nemours Children's Clinic - Pensacola | Pensacola | Florida | 32504 | — |
| All Children's Hospital | St. Petersburg | Florida | 33701 | — |
| Saint Joseph Children's Hospital of Tampa | Tampa | Florida | 33607 | — |
| Saint Mary's Hospital | West Palm Beach | Florida | 33407 | — |
| Children's Healthcare of Atlanta - Egleston | Atlanta | Georgia | 30322 | — |
| Georgia Regents University | Augusta | Georgia | 30912 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31403 | — |
| University of Hawaii | Honolulu | Hawaii | 96813 | — |
| Saint Luke's Mountain States Tumor Institute | Boise | Idaho | 83712 | — |
| University of Illinois | Chicago | Illinois | 60612 | — |
| Childrens Memorial Hospital | Chicago | Illinois | 60614 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Advocate Hope Children's Hospital | Oak Lawn | Illinois | 60453 | — |
| Advocate Lutheran General Hospital | Park Ridge | Illinois | 60068 | — |
| Southern Illinois University | Springfield | Illinois | 62702 | — |
| Riley Hospital for Children | Indianapolis | Indiana | 46202 | — |
| Saint Vincent Hospital and Health Services | Indianapolis | Indiana | 46260 | — |
| Raymond Blank Children's Hospital | Des Moines | Iowa | 50309 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Kosair Children's Hospital | Louisville | Kentucky | 40202 | — |
| Tulane University Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Children's Hospital-Main Campus | New Orleans | Louisiana | 70118 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Eastern Maine Medical Center | Bangor | Maine | 04401 | — |
| Maine Children's Cancer Program | Scarborough | Maine | 04074 | — |
| University of Maryland Greenebaum Cancer Center | Baltimore | Maryland | 21201-1595 | — |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287-8936 | — |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889-5600 | — |
| University of Massachusetts Medical School | Worcester | Massachusetts | 01655 | — |
| C S Mott Children's Hospital | Ann Arbor | Michigan | 48109 | — |
| Wayne State University | Detroit | Michigan | 48202 | — |
| Hurley Medical Center | Flint | Michigan | 48502 | — |
| Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan | 49503 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| Kalamazoo Center for Medical Studies | Kalamazoo | Michigan | 49008 | — |
| Michigan State University - Breslin Cancer Center | Lansing | Michigan | 48910 | — |
| Children's Hospitals and Clinics of Minnesota - Minneapolis | Minneapolis | Minnesota | 55404 | — |
| University of Minnesota Medical Center-Fairview | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| University of Missouri-Columbia | Columbia | Missouri | 65212 | — |
| The Childrens Mercy Hospital | Kansas City | Missouri | 64108 | — |
| Saint John's Mercy Medical Center | St Louis | Missouri | 63141 | — |
| Children's Hospital and Medical Center of Omaha | Omaha | Nebraska | 68114 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Nevada Cancer Research Foundation CCOP | Las Vegas | Nevada | 89106 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Saint Barnabas Medical Center | Livingston | New Jersey | 07039 | — |
| Morristown Memorial Hospital | Morristown | New Jersey | 07962 | — |
| Saint Peter's University Hospital | New Brunswick | New Jersey | 08901 | — |
| UMDNJ - Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08903 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| Saint Joseph's Regional Medical Center | Paterson | New Jersey | 07503 | — |
| Overlook Hospital | Summit | New Jersey | 07902 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87106 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| The Steven and Alexandra Cohen Children's Medical Center of New York | New Hyde Park | New York | 11040 | — |
| New York University Langone Medical Center | New York | New York | 10016 | — |
| Mount Sinai Medical Center | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | — |
| Montefiore Medical Center | The Bronx | New York | 10467-2490 | — |
| New York Medical College | Valhalla | New York | 10595 | — |
| Mission Hospitals Inc | Asheville | North Carolina | 28801 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27599 | — |
| Carolinas Medical Center | Charlotte | North Carolina | 28203 | — |
| Presbyterian Hospital | Charlotte | North Carolina | 28204 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| East Carolina University | Greenville | North Carolina | 27858 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Children's Hospital Medical Center of Akron | Akron | Ohio | 44308 | — |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| Rainbow Babies and Childrens Hospital | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | — |
| The Children's Medical Center of Dayton | Dayton | Ohio | 45404 | — |
| Mercy Children's Hospital | Toledo | Ohio | 43608 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Legacy Emanuel Children's Hospital | Portland | Oregon | 97227 | — |
| Legacy Emanuel Hospital and Health Center | Portland | Oregon | 97227 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | 18017 | — |
| Penn State Hershey Children's Hospital | Hershey | Pennsylvania | 17033 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Saint Christopher's Hospital for Children | Philadelphia | Pennsylvania | 19134 | — |
| Children's Hospital of Pittsburgh of UPMC | Pittsburgh | Pennsylvania | 15224 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Palmetto Health Richland | Columbia | South Carolina | 29203 | — |
| BI-LO Charities Children's Cancer Center | Greenville | South Carolina | 29605 | — |
| Greenville Cancer Treatment Center | Greenville | South Carolina | 29605 | — |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | — |
| T C Thompson Children's Hospital | Chattanooga | Tennessee | 37403 | — |
| East Tennessee Childrens Hospital | Knoxville | Tennessee | 37916 | — |
| Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| Texas Tech University Health Science Center-Amarillo | Amarillo | Texas | 79106 | — |
| Dell Children's Medical Center of Central Texas | Austin | Texas | 78723 | — |
| Driscoll Children's Hospital | Corpus Christi | Texas | 78411 | — |
| Medical City Dallas Hospital | Dallas | Texas | 75230 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Brooke Army Medical Center | Fort Sam Houston | Texas | 78234 | — |
| Cook Children's Medical Center | Fort Worth | Texas | 76104 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Covenant Children's Hospital | Lubbock | Texas | 79410 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229-3900 | — |
| Methodist Children's Hospital of South Texas | San Antonio | Texas | 78229 | — |
| Scott and White Memorial Hospital | Temple | Texas | 76508 | — |
| Primary Children's Medical Center | Salt Lake City | Utah | 84113 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| Childrens Hospital-King's Daughters | Norfolk | Virginia | 23507 | — |
| Carilion Clinic Children's Hospital | Roanoke | Virginia | 24014 | — |
| Providence Sacred Heart Medical Center and Children's Hospital | Spokane | Washington | 99204 | — |
| Mary Bridge Children's Hospital and Health Center | Tacoma | Washington | 98405 | — |
| Madigan Army Medical Center | Tacoma | Washington | 98431 | — |
| West Virginia University Charleston | Charleston | West Virginia | 25304 | — |
| Saint Vincent Hospital | Green Bay | Wisconsin | 54301 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
| Midwest Children's Cancer Center | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00381680, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 25, 2024 · Synced Sep 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00381680 live on ClinicalTrials.gov.