DORADO-AC-EX - A Long-Term Safety Extension Study to the Phase 3 DORADOC-AC Study (Protocol DAR-312) of Darusentan in Resistant Hypertension
Public ClinicalTrials.gov record NCT00389675. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Active-Controlled, Long-Term Safety Extension Study of Optimized Doses of Darusentan in Subjects With Resistant Hypertension Despite Receiving Combination Therapy With Three or More Antihypertensive Drugs, Including a Diuretic, as Compared to Guanfacine (Protocol DAR-312-E)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a double-blind, active-controlled, long-term study of a new experimental drug called darusentan. Darusentan in not currently approved by the United States Food and Drug Administration (FDA), which means that a doctor cannot prescribe this drug. The purpose of this study is to evaluate the long-term safety of darusentan (optimized dose) as compared to an active control, administered orally.
Study identification
- NCT ID
- NCT00389675
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 661 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 35 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2007 (Type not available)
- Primary completion
- Feb 2010 (Actual)
- Completion
- May 2010 (Actual)
- Last update posted
- Jan 6, 2014
2007 – 2010
United States locations
- U.S. sites
- 85
- U.S. states
- 29
- U.S. cities
- 72
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Internal Medicine, PC | Birmingham | Alabama | 35235 | — |
| Greystone Medical Research, LLC | Birmingham | Alabama | 35242 | — |
| The Heart Center, PC | Huntsville | Alabama | 35801 | — |
| Mulberry Medical Associates, PC | Montgomery | Alabama | 36106 | — |
| Arizona Center for Clinical Research | Glendale | Arizona | 85306 | — |
| Cardiovascular Consultants, Ltd. | Glendale | Arizona | 85306 | — |
| Lovelace Scientific Resource, Inc. | Phoenix | Arizona | 85016 | — |
| Cochise Clinical Research | Sierra Vista | Arizona | 85635 | — |
| Southwest Heart | Tucson | Arizona | 85715 | — |
| HealthFirst Physicians of AR, PA dba Convenient Care Clinic | Hot Springs | Arkansas | 71913 | — |
| NEA Clinical | Jonesboro | Arkansas | 72401 | — |
| Arkansas Primary Care Clinic, PA | Little Rock | Arkansas | 72204 | — |
| Medical Investigators, Inc. | Little Rock | Arkansas | 72205 | — |
| Highgrove Medical Center | Bakersfield | California | 93301 | — |
| Central Cardiology Medical Clinic | Bakersfield | California | 93308 | — |
| Impact Clinical Trials | Beverly Hills | California | 90211 | — |
| VA Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | — |
| Rancho Cucamonga Clinical Trials | Rancho Cucamonga | California | 91730 | — |
| Pacific Heart Institute | Santa Monica | California | 90404 | — |
| Los angeles biomedical research Institute at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| Aurora Denver Cardiology Associates | Aurora | Colorado | 80012 | — |
| Aurora Denver Cardiology Associates | Denver | Colorado | 80218 | — |
| Clinical Research of South Florida | Coral Gables | Florida | 33134 | — |
| Doctors Medical center of Walton County | DeFuniak Springs | Florida | 32435 | — |
| Broward General Medical Center | Fort Lauderdale | Florida | 33316 | — |
| Maxine Hamilton, MD, PA | Fort Lauderdale | Florida | 33316 | — |
| St John's Center for Clinical Research | Jacksonville | Florida | 32259 | — |
| Private Practice of Dr. Bridget Bellingar | Largo | Florida | 33773 | — |
| A + Research Inc. | Miami | Florida | 33144 | — |
| AppleMed Research, Inc. | Miami | Florida | 33155 | — |
| Internal Medicine Associates of South Florida | North Miami Beach | Florida | 33179 | — |
| Ormond Medical Arts Pharmaceutical Research Center | Ormond Beach | Florida | 32174 | — |
| Nothwest Florida Heart Group, PA-Research Dept | Pensacola | Florida | 32514 | — |
| Cardiovascular Center of Sarasota | Sarasota | Florida | 34231 | — |
| Suncoast Cardiovascular Research, Inc | St. Petersburg | Florida | 33701 | — |
| Tampa Bay Nephrology Associates, PL | Tampa | Florida | 33603 | — |
| Orlando Rangel, MD, PA | Tampa | Florida | 33607 | — |
| AMR Research Associates, LLC | Bogart | Georgia | 30622 | — |
| Atlanta Vascular Research Foundation | Tucker | Georgia | 30084 | — |
| Consultants in Cardiovascular Med (CIS) | Melrose Park | Illinois | 60160 | — |
| Illinois Heart & Lunch Research Center | Normal | Illinois | 61761 | — |
| Methodist Medical Center-Heart, Lung & Vascular Institute | Peoria | Illinois | 61606 | — |
| Medical consultants, PC | Muncie | Indiana | 47303 | — |
| University Medical Associates | Louisville | Kentucky | 40202 | — |
| Dr. Jeffrey Chen | Lafayette | Louisiana | 70503 | — |
| Louisiana Research Associates, Inc. | New Orleans | Louisiana | 70114 | — |
| Maine Research Associates | Auburn | Maine | 04210 | — |
| PrimeCare Internal Medicine | Biddeford | Maine | 04005 | — |
| Great Lakes Heart Center of Alpena | Alpena | Michigan | 49707 | — |
| Internal Medicine of Northern Michigan | Petoskey | Michigan | 49770 | — |
| Minneapolis VAMC | Minneapolis | Minnesota | 55417 | — |
| Central Minnesota Heart Center at St. Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| St. Paul Cardiology | Saint Paul | Minnesota | 55102 | — |
| Glacier View Cardiology, PC | Kalispell | Montana | 59901 | — |
| Impact Clinical Trials | Las Vegas | Nevada | 89106 | — |
| NJ Heart | Linden | New Jersey | 07036 | — |
| New Jersey Physicians | Passaic | New Jersey | 07055 | — |
| Lifeline Research Institute | Brooklyn | New York | 11214 | — |
| Metrolina Internal Medicine, PA | Charlotte | North Carolina | 28204 | — |
| Heart Care Center of Charlotte | Charlotte | North Carolina | 28211 | — |
| Physicians East, PA | Winterville | North Carolina | 27858 | — |
| Plaza Medical Group, PC | Oklahoma City | Oklahoma | 73112 | — |
| Castlerock Clinical Research Consultants, LLC | Tulsa | Oklahoma | 74136 | — |
| Integrated Medical Research PC | Ashland | Oregon | 97520 | — |
| Blackstone Cardiology Associates | Pawtucket | Rhode Island | 02860 | — |
| Charleston Cardiology | Charleston | South Carolina | 29403 | — |
| Paris View Family Practice | Greenville | South Carolina | 29601 | — |
| Internal Medicine of Greer | Greer | South Carolina | 29651 | — |
| Scenic City Research | Cleveland | Tennessee | 37311 | — |
| Southeast Texas Clinical Research Center | Beaumont | Texas | 77702 | — |
| Cardiovascular Research Inst. of Dallas | Dallas | Texas | 75231 | — |
| Galenos Research | Dallas | Texas | 75251 | — |
| Sergio F Rovner, MD | El Paso | Texas | 79935 | — |
| Salim Gopalani, MD, PA | Houston | Texas | 77008 | — |
| Humayum Mirza, MD, PA | Houston | Texas | 77055 | — |
| Clinical Trial Network | Houston | Texas | 77074 | — |
| Houston Clinical Research Assoc. | Houston | Texas | 77090 | — |
| Innovative Research of West Florida | Hurst | Texas | 76054 | — |
| North Texas Medical Research | Plano | Texas | 75093 | — |
| Scott & White Memorial Hospital | Temple | Texas | 76508 | — |
| Fletcher Allen Health Care/University of Vermont | Burlington | Vermont | 05401 | — |
| Kamlesh N Dave Cardiology | Hopewell | Virginia | 23860 | — |
| WVU Physicicans of Charleston | Charleston | West Virginia | 25304 | — |
| Alpha Medical Research, LLC | Madison | Wisconsin | 43717 | — |
| Executive Health and Research Associates | Madison | Wisconsin | 53717 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00389675, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 6, 2014 · Synced Oct 16, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00389675 live on ClinicalTrials.gov.