ClinicalTrials.gov record
DORADO-AC - Optimized Doses of Darusentan as Compared to an Active Control in Resistant Hypertension
ClinicalTrials.gov ID: NCT00389779
Public ClinicalTrials.gov record NCT00389779. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized, Double-Blind, Placebo- and Active-Controlled, Multi-center, Parallel Group Study to Evaluate the Safety and Efficacy of Darusentan in Subjects With Resistant Hypertension Receiving Combination Therapy With Three or More Antihypertensive Drugs, Including a Diuretic, as Compared to Guanfacine or Placebo (Protocol DAR-312)
Study identification
- NCT ID
- NCT00389779
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Gilead Sciences
- Industry
- Enrollment
- 849 participants
Conditions and interventions
Conditions
Interventions
- Darusentan Drug
- Guanfacine Drug
- Darusentan Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 35 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 31, 2006
- Primary completion
- Jul 31, 2009
- Completion
- Jul 31, 2009
- Last update posted
- Mar 17, 2014
2006 – 2009
United States locations
- U.S. sites
- 87
- U.S. states
- 29
- U.S. cities
- 73
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Internal Medicine, PC | Birmingham | Alabama | 35235 | — |
| Greystone Medical Research, LLC | Birmingham | Alabama | 35242 | — |
| The Heart Center, PC | Huntsville | Alabama | 35801 | — |
| Mulberry Medical Associates, PC | Montgomery | Alabama | 36106 | — |
| Arizona Center for Clinical Research | Glendale | Arizona | 85306 | — |
| Cardiovascular Consultants, Ltd. | Glendale | Arizona | 85306 | — |
| Lovelace Scientific Resources, Inc | Phoenix | Arizona | 85016 | — |
| Cochise Clinical Research | Sierra Vista | Arizona | 85635 | — |
| Southwest Heart | Tucson | Arizona | 85715 | — |
| HealthFirst Physician of AR, PA dba Convenient Care Clinic | Hot Springs | Arkansas | 71913 | — |
| NEA Clinic | Jonesboro | Arkansas | 72401 | — |
| Arkansas Primary Care Clinic, PA | Little Rock | Arkansas | 72204 | — |
| Medical Investigations Inc. | Little Rock | Arkansas | 72205 | — |
| Highgrove Medical Center | Bakersfield | California | 93301 | — |
| Central Cardiology Medical Clinic | Bakersfield | California | 93308 | — |
| Impact Clinical Trials | Beverly Hills | California | 90211 | — |
| VA Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | — |
| Rancho Cucamonga Clinical Trials | Rancho Cucamonga | California | 91730 | — |
| Pacific Heart Institute | Santa Monica | California | 90404 | — |
| Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| Aurora Denver Cardiology Associates | Aurora | Colorado | 80012 | — |
| Aurora Denver Cardiology Associates | Aurora | Colorado | 80218 | — |
| Clinical Research of South Florida | Coral Gables | Florida | 33134 | — |
| Doctors Medical Center of Walton County | DeFuniak Springs | Florida | 32435 | — |
| Broward General Medical Center | Fort Lauderdale | Florida | 33316 | — |
| Maxine Hamilton, MD, PA | Fort Lauderdale | Florida | 33316 | — |
| St. John's Center for Clinical Research | Jacksonville | Florida | 32259 | — |
| Private Practice of Dr. Bridget Bellingar | Largo | Florida | 33773 | — |
| A+ Research Inc. | Miami | Florida | 33144 | — |
| AppleMed Research, Inc. | Miami | Florida | 33155 | — |
| Internal Medicine Associates of South Florida | North Miami Beach | Florida | 33179 | — |
| Ormond Medical Arts Pharmaceutical Research center | Ormond Beach | Florida | 32174 | — |
| Northwest Florida Heart Group, PA - Research Dept | Pensacola | Florida | 32514 | — |
| Cardiovascular Center of Sarasota | Sarasota | Florida | 34231 | — |
| Suncoast Cardiovascular Research, Inc. | St. Petersburg | Florida | 33701 | — |
| Tampa Bay Nephrology Associates, PL | Tampa | Florida | 33603 | — |
| Orlando Rangel, MD, PA | Tampa | Florida | 33607 | — |
| Medical College of Georgia | Augusta | Georgia | 30912 | — |
| AMR Research Associates, LLC | Bogart | Georgia | 30622 | — |
| Atlanta Vascular Research Foundation | Tucker | Georgia | 30084 | — |
| North Shore Cardiologist | Bannockburn | Illinois | 60015 | — |
| Consultants in Cardiovascular Med (CIS) | Melrose Park | Illinois | 60160 | — |
| Illinois Heart & Lunch Research | Normal | Illinois | 61761 | — |
| Methodist Medical Center-Heart, Lung & Vascular Institute | Peoria | Illinois | 61606 | — |
| Medical Consultants, PC | Muncie | Indiana | 47303 | — |
| University Medical Associates | Louisville | Kentucky | 40202 | — |
| Dr. Jeffrey Chen | Lafayette | Louisiana | 70503 | — |
| Louisiana Research Associates, Inc | New Orleans | Louisiana | 70114 | — |
| Maine Research Associate | Auburn | Maine | 04210 | — |
| PrimeCare Internal Medicine | Biddeford | Maine | 04005 | — |
| Great Lakes Heart Center of Alpena | Alpena | Michigan | 49707 | — |
| Internal Medicine of Nothern Michigan | Petoskey | Michigan | 49770 | — |
| Minneapolis VAMC | Minneapolis | Minnesota | 55417 | — |
| Central Minnesota Heart Center at St. Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| St. Paul Cardiology | Saint Paul | Minnesota | 55102 | — |
| Glacier View Cardiology, PC | Kalispell | Montana | 59901 | — |
| Impact Clinical Trials | Las Vegas | Nevada | 89106 | — |
| NJ Heart | Linden | New Jersey | 07036 | — |
| New Jersey Physicians | Passaic | New Jersey | 07055 | — |
| Lifeline Research Institute | Brooklyn | New York | 11214 | — |
| Metrolina Internal Medicine, PA | Charlotte | North Carolina | 28204 | — |
| Heart Care Center of Charlotte | Charlotte | North Carolina | 28211 | — |
| Physicians East, PA | Winterville | North Carolina | 27858 | — |
| Plaza Medical Group, PC | Oklahoma City | Oklahoma | 73112 | — |
| Castlerock Clinical Research Counsultants, LLC | Tulsa | Oklahoma | 74136 | — |
| Integrated Medical Research PC | Ashland | Oregon | 97520 | — |
| Blackstone Cardiology Associates | Pawtucket | Rhode Island | 02860 | — |
| Charleston Cardiology | Charleston | South Carolina | 29403 | — |
| Paris View Family Practice | Greenville | South Carolina | 29601 | — |
| Internal Medicine of Greer | Greer | South Carolina | 29651 | — |
| Scenic City Research | Cleveland | Tennessee | 37311 | — |
| Southeast Texas Clinical Research Center | Beaumont | Texas | 77702 | — |
| Cardiovascular Research Inst. of Dallas | Dallas | Texas | 75231 | — |
| Galenos Research | Dallas | Texas | 75251 | — |
| Sergio F Rovner, MD | El Paso | Texas | 79935 | — |
| Salim Gopalani, MD, PA | Houston | Texas | 77008 | — |
| Humayun Mirza, MD, PA | Houston | Texas | 77055 | — |
| Clinical Trial Network | Houston | Texas | 77074 | — |
| Houston Clinical Research Assoc. | Houston | Texas | 77090 | — |
| Innovative Research of West Florida | Hurst | Texas | 76054 | — |
| North Texas Medical Research | Plano | Texas | 75093 | — |
| Scott & White Memorial Hospital | Temple | Texas | 76508 | — |
| Fletcher Allen Health Care/University of Vermont | Burlington | Vermont | 05401 | — |
| Kamlesh N. Dave Cardiology | Hopewell | Virginia | 23860 | — |
| WVU Physicians of Charleston | Charleston | West Virginia | 25304 | — |
| Alpha Medical Research, LLC | Madison | Wisconsin | 43717 | — |
| Executive Health and Research Associates | Madison | Wisconsin | 53717 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 60 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00389779, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 17, 2014 · Synced Jun 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00389779 live on ClinicalTrials.gov.